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Contribution of Apical and Basal Dendrites of L2/3 Pyramidal Neurons to Orientation Encoding in Mouse V1

Jiyoung Park, Athanasia Papoutsi, Ryan T. Ash, Miguel A. Marin, Panayiota Poirazi, Stelios M. Smirnakis
doi: https://doi.org/10.1101/566588
Jiyoung Park
1Program in Structural and Computational Biology and Molecular Biophysics, Baylor College of Medicine, Houston, Texas
4Brigham and Women’s Hospital and Jamaica Plain VA Hospital, Harvard Medical School, Boston, MA
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  • For correspondence: jpark78@bwh.harvard.edu poirazi@imbb.forth.gr smsmirnakis@bwh.harvard.edu
Athanasia Papoutsi
3Institute of Molecular Biology and Biotechnology (IMBB), Foundation of Research and Technology Hellas (FORTH), Vassilika Vouton, Heraklion, Crete, Greece
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Ryan T. Ash
2Department of Neuroscience, Baylor College of Medicine, Houston, Texas
4Brigham and Women’s Hospital and Jamaica Plain VA Hospital, Harvard Medical School, Boston, MA
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Miguel A. Marin
2Department of Neuroscience, Baylor College of Medicine, Houston, Texas
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Panayiota Poirazi
3Institute of Molecular Biology and Biotechnology (IMBB), Foundation of Research and Technology Hellas (FORTH), Vassilika Vouton, Heraklion, Crete, Greece
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  • For correspondence: jpark78@bwh.harvard.edu poirazi@imbb.forth.gr smsmirnakis@bwh.harvard.edu
Stelios M. Smirnakis
4Brigham and Women’s Hospital and Jamaica Plain VA Hospital, Harvard Medical School, Boston, MA
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  • For correspondence: jpark78@bwh.harvard.edu poirazi@imbb.forth.gr smsmirnakis@bwh.harvard.edu
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Abstract

Pyramidal neurons integrate synaptic inputs from basal and apical dendrites to generate stimulus-specific responses. It has been proposed that feed-forward inputs to basal dendrites drive a neuron’s stimulus preference, while feedback inputs to apical dendrites sharpen selectivity. However, how a neuron’s dendritic domains relate to its functional selectivity has not been demonstrated experimentally. We performed 2-photon dendritic micro-dissection on layer-2/3 pyramidal neurons in mouse primary visual cortex. We found that removing the apical dendritic tuft did not alter orientation-tuning. Furthermore, orientation-tuning curves were remarkably robust to the removal of basal dendrites: ablation of 2-3 basal dendrites was needed to cause a small shift in orientation preference, without significantly altering tuning width. Computational modeling corroborated our results and put limits on how orientation preferences among basal dendrites differ in order to reproduce the post-ablation data. In conclusion, neuronal orientation-tuning appears remarkably robust to loss of dendritic input.

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Posted March 05, 2019.
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Contribution of Apical and Basal Dendrites of L2/3 Pyramidal Neurons to Orientation Encoding in Mouse V1
Jiyoung Park, Athanasia Papoutsi, Ryan T. Ash, Miguel A. Marin, Panayiota Poirazi, Stelios M. Smirnakis
bioRxiv 566588; doi: https://doi.org/10.1101/566588
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Contribution of Apical and Basal Dendrites of L2/3 Pyramidal Neurons to Orientation Encoding in Mouse V1
Jiyoung Park, Athanasia Papoutsi, Ryan T. Ash, Miguel A. Marin, Panayiota Poirazi, Stelios M. Smirnakis
bioRxiv 566588; doi: https://doi.org/10.1101/566588

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