New Results
FUS ALS-causative mutations impact FUS autoregulation and the processing of RNA-binding proteins through intron retention
View ORCID ProfileJack Humphrey, Nicol Birsa, Carmelo Milioto, David Robaldo, Andrea B Eberle, Rahel Kräuchi, View ORCID ProfileMatthew Bentham, Agnieszka M. Ule, Seth Jarvis, Cristian Bodo, Maria Giovanna Garone, View ORCID ProfileAnny Devoy, View ORCID ProfileAlessandro Rosa, View ORCID ProfileIrene Bozzoni, View ORCID ProfileElizabeth MC Fisher, View ORCID ProfileMarc-David Ruepp, Oliver Mühlemann, View ORCID ProfileGiampietro Schiavo, View ORCID ProfileAdrian M Isaacs, View ORCID ProfileVincent Plagnol, View ORCID ProfilePietro Fratta
doi: https://doi.org/10.1101/567735
Jack Humphrey
1UCL Queen Square Institute of Neurology, University College London, London WC1N 6BG, UK
2UK Dementia Research Institute, London, UK
4UCL Genetics Institute, University College London, London WC1E 6BT, UK
Nicol Birsa
1UCL Queen Square Institute of Neurology, University College London, London WC1N 6BG, UK
Carmelo Milioto
1UCL Queen Square Institute of Neurology, University College London, London WC1N 6BG, UK
2UK Dementia Research Institute, London, UK
David Robaldo
1UCL Queen Square Institute of Neurology, University College London, London WC1N 6BG, UK
2UK Dementia Research Institute, London, UK
Andrea B Eberle
3Department of Chemistry and Biochemistry, University of Bern, Freiestrasse 3, 3012 Bern, Switzerland
Rahel Kräuchi
3Department of Chemistry and Biochemistry, University of Bern, Freiestrasse 3, 3012 Bern, Switzerland
Matthew Bentham
1UCL Queen Square Institute of Neurology, University College London, London WC1N 6BG, UK
Agnieszka M. Ule
1UCL Queen Square Institute of Neurology, University College London, London WC1N 6BG, UK
Seth Jarvis
1UCL Queen Square Institute of Neurology, University College London, London WC1N 6BG, UK
2UK Dementia Research Institute, London, UK
4UCL Genetics Institute, University College London, London WC1E 6BT, UK
Cristian Bodo
1UCL Queen Square Institute of Neurology, University College London, London WC1N 6BG, UK
Maria Giovanna Garone
5Sapienza University of Rome, Rome, IT
Anny Devoy
1UCL Queen Square Institute of Neurology, University College London, London WC1N 6BG, UK
2UK Dementia Research Institute, London, UK
6Maurice Wohl Clinical Neuroscience Institute, King’s College London, London, UK
Alessandro Rosa
5Sapienza University of Rome, Rome, IT
7Center for Life Nano Science, Istituto Italiano di Tecnologia, Rome, IT
Irene Bozzoni
5Sapienza University of Rome, Rome, IT
7Center for Life Nano Science, Istituto Italiano di Tecnologia, Rome, IT
Elizabeth MC Fisher
1UCL Queen Square Institute of Neurology, University College London, London WC1N 6BG, UK
Marc-David Ruepp
2UK Dementia Research Institute, London, UK
6Maurice Wohl Clinical Neuroscience Institute, King’s College London, London, UK
Oliver Mühlemann
3Department of Chemistry and Biochemistry, University of Bern, Freiestrasse 3, 3012 Bern, Switzerland
Giampietro Schiavo
1UCL Queen Square Institute of Neurology, University College London, London WC1N 6BG, UK
8Discoveries Centre for Regenerative and Precision Medicine, University College London Campus, London WC1N 3BG, UK
Adrian M Isaacs
1UCL Queen Square Institute of Neurology, University College London, London WC1N 6BG, UK
2UK Dementia Research Institute, London, UK
Vincent Plagnol
4UCL Genetics Institute, University College London, London WC1E 6BT, UK
Pietro Fratta
1UCL Queen Square Institute of Neurology, University College London, London WC1N 6BG, UK
Article usage
Posted June 18, 2019.
FUS ALS-causative mutations impact FUS autoregulation and the processing of RNA-binding proteins through intron retention
Jack Humphrey, Nicol Birsa, Carmelo Milioto, David Robaldo, Andrea B Eberle, Rahel Kräuchi, Matthew Bentham, Agnieszka M. Ule, Seth Jarvis, Cristian Bodo, Maria Giovanna Garone, Anny Devoy, Alessandro Rosa, Irene Bozzoni, Elizabeth MC Fisher, Marc-David Ruepp, Oliver Mühlemann, Giampietro Schiavo, Adrian M Isaacs, Vincent Plagnol, Pietro Fratta
bioRxiv 567735; doi: https://doi.org/10.1101/567735
FUS ALS-causative mutations impact FUS autoregulation and the processing of RNA-binding proteins through intron retention
Jack Humphrey, Nicol Birsa, Carmelo Milioto, David Robaldo, Andrea B Eberle, Rahel Kräuchi, Matthew Bentham, Agnieszka M. Ule, Seth Jarvis, Cristian Bodo, Maria Giovanna Garone, Anny Devoy, Alessandro Rosa, Irene Bozzoni, Elizabeth MC Fisher, Marc-David Ruepp, Oliver Mühlemann, Giampietro Schiavo, Adrian M Isaacs, Vincent Plagnol, Pietro Fratta
bioRxiv 567735; doi: https://doi.org/10.1101/567735
Subject Area
Subject Areas
- Biochemistry (11753)
- Bioengineering (8752)
- Bioinformatics (29201)
- Biophysics (14974)
- Cancer Biology (12100)
- Cell Biology (17413)
- Clinical Trials (138)
- Developmental Biology (9422)
- Ecology (14182)
- Epidemiology (2067)
- Evolutionary Biology (18309)
- Genetics (12245)
- Genomics (16804)
- Immunology (11869)
- Microbiology (28098)
- Molecular Biology (11596)
- Neuroscience (60975)
- Paleontology (451)
- Pathology (1871)
- Pharmacology and Toxicology (3238)
- Physiology (4959)
- Plant Biology (10427)
- Synthetic Biology (2886)
- Systems Biology (7340)
- Zoology (1651)