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Mapping the human subcortical auditory system using histology, post mortem MRI and in vivo MRI at 7T

View ORCID ProfileKevin Richard Sitek, View ORCID ProfileOmer Faruk Gulban, Evan Calabrese, G. Allan Johnson, Agustin Lage-Castellanos, Michelle Moerel, View ORCID ProfileSatrajit S. Ghosh, Federico De Martino
doi: https://doi.org/10.1101/568139
Kevin Richard Sitek
1MIT
2Harvard University
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  • For correspondence: ksitek@mit.edu
Omer Faruk Gulban
3Department of Cognitive Neuroscience, Faculty of Psychology and Neuroscience, Maastricht University, The Netherlands
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Evan Calabrese
4Duke University
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G. Allan Johnson
4Duke University
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Agustin Lage-Castellanos
3Department of Cognitive Neuroscience, Faculty of Psychology and Neuroscience, Maastricht University, The Netherlands
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Michelle Moerel
3Department of Cognitive Neuroscience, Faculty of Psychology and Neuroscience, Maastricht University, The Netherlands
5Maastricht Centre for Systems Biology, Faculty of Science and Engineering, Maastricht University, The Netherlands
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Satrajit S. Ghosh
1MIT
2Harvard University
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Federico De Martino
3Department of Cognitive Neuroscience, Faculty of Psychology and Neuroscience, Maastricht University, The Netherlands
6Center for Magnetic Resonance Research, University of Minnesota, Minneapolis, USA
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Abstract

Studying the human subcortical auditory system non-invasively is challenging due to its small, densely packed structures deep within the brain. Additionally, the elaborate three-dimensional (3-D) structure of the system can be difficult to understand based on currently available 2-D schematics and animal models. We addressed these issues using a combination of histological data, post mortem magnetic resonance imaging (MRI), and in vivo MRI at 7 Tesla. We created anatomical atlases based on state-of-the-art human histology (BigBrain) and post mortem MRI (50 μm). We measured functional MRI (fMRI) responses to natural sounds and demonstrate that the functional localization of subcortical structures is reliable within individual participants who were scanned in two different experiments. Further, a group functional atlas derived from the functional data locates these structures with a median distance below 2mm. Using diffusion MRI tractography, we revealed structural connectivity maps of the human subcortical auditory pathway both in vivo (1050 μm isotropic resolution) and post mortem (200 μm isotropic resolution). This work captures current MRI capabilities for investigating the human subcortical auditory system, describes challenges that remain, and contributes novel, openly available data, atlases, and tools for researching the human auditory system.

Footnotes

  • Added second in vivo functional experiment; revised figures; revised text; included supplementary videos

  • Glossary

    Anatomical abbreviations
    AVCN
    Anteroventral cochlear nucleus.
    CN
    Cochlear nucleus.
    CNVIII
    8th nerve, vestibulocochlear nerve.
    DCN
    Dorsal cochclear nucleus.
    IC
    Inferior colliculus.
    LGN
    Lateral geniculate nucleus.
    LSO
    Lateral superior olive.
    MGB/MGN
    Medial geniculate body/nucleus.
    MNTB
    Medial nucleus of the trapezoid body.
    MSO
    Medial superior olive.
    PVCN
    Posteroventral cochlear nucleus.
    SOC
    Superior olivary complex.
  • MRI acquisition abbreviations

    7T
    7 Tesla.
    dMRI
    diffusion magnetic resonance imaging.
    FOV
    Field of view.
    fMRI
    functional magnetic resonance imaging.
    GRAPPA
    Generalized auto-calibrating partially parallel acquisitions.
    MB
    Multi-band.
    MPRAGE
    Magnetization prepared rapid acquisition gradient echo.
    MRI
    Magnetic resonance imaging.
    PDw
    Proton density weighted.
    SI-T1w
    Short inversion time T1-weighted.
    T1w
    T1-weighted.
    T2*w
    T2*-weighted.
    TE
    Echo time.
    TR
    Repetition time.
  • Data analysis abbreviations

    CSD
    Constrained spherical deconvolution.
    FA
    Fractional anisotropy.
    FDR
    False discovery rate.
    FOD
    Fiber orientation distribution.
    GLM
    General linear model.
    HCP
    Human connectome project.
    HRF
    Hemodynamic response function.
    ICBM
    Internation Consortium for Brain Mapping.
    M0
    T2 signal with no diffusion weighting.
    MD
    Mean diffusivity.
    MNI
    Montreal Neurological Institude.
    MSMT
    Multi-shell multi-tissue.
    ODFs
    Orientation distribution functions.
    ROI
    Region of interest.
  • Copyright 
    The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY 4.0 International license.
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    Posted June 04, 2019.
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    Mapping the human subcortical auditory system using histology, post mortem MRI and in vivo MRI at 7T
    Kevin Richard Sitek, Omer Faruk Gulban, Evan Calabrese, G. Allan Johnson, Agustin Lage-Castellanos, Michelle Moerel, Satrajit S. Ghosh, Federico De Martino
    bioRxiv 568139; doi: https://doi.org/10.1101/568139
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    Mapping the human subcortical auditory system using histology, post mortem MRI and in vivo MRI at 7T
    Kevin Richard Sitek, Omer Faruk Gulban, Evan Calabrese, G. Allan Johnson, Agustin Lage-Castellanos, Michelle Moerel, Satrajit S. Ghosh, Federico De Martino
    bioRxiv 568139; doi: https://doi.org/10.1101/568139

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