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A robotic platform for fluidically-linked human body-on-chips experimentation
View ORCID ProfileRichard Novak, Miles Ingram, Susan Clauson, Debarun Das, Aaron Delahanty, Anna Herland, Ben M. Maoz, Sauveur S. F. Jeanty, Mahadevabharath R. Somayaji, Morgan Burt, Elizabeth Calamari, Angeliki Chalkiadaki, Alexander Cho, Youngjae Choe, David Benson Chou, Michael Cronce, Stephanie Dauth, Toni Divic, Jose Fernandez-Alcon, Thomas Ferrante, John Ferrier, Edward A. FitzGerald, Rachel Fleming, Sasan Jalili-Firoozinezhad, Thomas Grevesse, Josue A. Goss, Tiama Hamkins-Indik, Olivier Henry, Chris Hinojosa, Tessa Huffstater, Kyung-Jin Jang, Ville Kujala, Lian Leng, Robert Mannix, Yuka Milton, Janna Nawroth, Bret A. Nestor, Carlos F. Ng, Blakely O’Connor, Tae-Eun Park, Henry Sanchez, Josiah Sliz, Alexandra Sontheimer-Phelps, Ben Swenor, Guy Thompson II, George J. Touloumes, Zachary Tranchemontagne, Norman Wen, Moran Yadid, Anthony Bahinski, Geraldine A. Hamilton, Daniel Levner, Oren Levy, Andrzej Przekwas, Rachelle Prantil-Baun, Kevin K. Parker, Donald E. Ingber
doi: https://doi.org/10.1101/569541
Richard Novak
1Wyss Institute for Biologically Inspired Engineering at Harvard University, Boston, MA 02115, USA;
Miles Ingram
1Wyss Institute for Biologically Inspired Engineering at Harvard University, Boston, MA 02115, USA;
Susan Clauson
1Wyss Institute for Biologically Inspired Engineering at Harvard University, Boston, MA 02115, USA;
Debarun Das
2CFD Research Corporation, Huntsville, AL, USA 35806;
Aaron Delahanty
1Wyss Institute for Biologically Inspired Engineering at Harvard University, Boston, MA 02115, USA;
Anna Herland
1Wyss Institute for Biologically Inspired Engineering at Harvard University, Boston, MA 02115, USA;
Ben M. Maoz
1Wyss Institute for Biologically Inspired Engineering at Harvard University, Boston, MA 02115, USA;
3Harvard John A. Paulson School of Engineering and Applied Sciences, Harvard University, Cambridge, MA 02138, USA;
Sauveur S. F. Jeanty
1Wyss Institute for Biologically Inspired Engineering at Harvard University, Boston, MA 02115, USA;
Mahadevabharath R. Somayaji
2CFD Research Corporation, Huntsville, AL, USA 35806;
Morgan Burt
1Wyss Institute for Biologically Inspired Engineering at Harvard University, Boston, MA 02115, USA;
Elizabeth Calamari
1Wyss Institute for Biologically Inspired Engineering at Harvard University, Boston, MA 02115, USA;
Angeliki Chalkiadaki
1Wyss Institute for Biologically Inspired Engineering at Harvard University, Boston, MA 02115, USA;
Alexander Cho
2CFD Research Corporation, Huntsville, AL, USA 35806;
Youngjae Choe
1Wyss Institute for Biologically Inspired Engineering at Harvard University, Boston, MA 02115, USA;
David Benson Chou
1Wyss Institute for Biologically Inspired Engineering at Harvard University, Boston, MA 02115, USA;
4Department of Pathology, Massachusetts General Hospital, Boston, MA 02115, USA;
Michael Cronce
1Wyss Institute for Biologically Inspired Engineering at Harvard University, Boston, MA 02115, USA;
Stephanie Dauth
1Wyss Institute for Biologically Inspired Engineering at Harvard University, Boston, MA 02115, USA;
3Harvard John A. Paulson School of Engineering and Applied Sciences, Harvard University, Cambridge, MA 02138, USA;
Toni Divic
1Wyss Institute for Biologically Inspired Engineering at Harvard University, Boston, MA 02115, USA;
Jose Fernandez-Alcon
1Wyss Institute for Biologically Inspired Engineering at Harvard University, Boston, MA 02115, USA;
Thomas Ferrante
1Wyss Institute for Biologically Inspired Engineering at Harvard University, Boston, MA 02115, USA;
John Ferrier
1Wyss Institute for Biologically Inspired Engineering at Harvard University, Boston, MA 02115, USA;
3Harvard John A. Paulson School of Engineering and Applied Sciences, Harvard University, Cambridge, MA 02138, USA;
Edward A. FitzGerald
1Wyss Institute for Biologically Inspired Engineering at Harvard University, Boston, MA 02115, USA;
Rachel Fleming
1Wyss Institute for Biologically Inspired Engineering at Harvard University, Boston, MA 02115, USA;
Sasan Jalili-Firoozinezhad
1Wyss Institute for Biologically Inspired Engineering at Harvard University, Boston, MA 02115, USA;
5Department of Bioengineering and iBB - Institute for Bioengineering and Biosciences, Instituto Superior Técnico, Universidade de Lisboa, Lisboa, Portugal;
Thomas Grevesse
1Wyss Institute for Biologically Inspired Engineering at Harvard University, Boston, MA 02115, USA;
3Harvard John A. Paulson School of Engineering and Applied Sciences, Harvard University, Cambridge, MA 02138, USA;
Josue A. Goss
1Wyss Institute for Biologically Inspired Engineering at Harvard University, Boston, MA 02115, USA;
3Harvard John A. Paulson School of Engineering and Applied Sciences, Harvard University, Cambridge, MA 02138, USA;
Tiama Hamkins-Indik
1Wyss Institute for Biologically Inspired Engineering at Harvard University, Boston, MA 02115, USA;
Olivier Henry
1Wyss Institute for Biologically Inspired Engineering at Harvard University, Boston, MA 02115, USA;
Chris Hinojosa
1Wyss Institute for Biologically Inspired Engineering at Harvard University, Boston, MA 02115, USA;
Tessa Huffstater
1Wyss Institute for Biologically Inspired Engineering at Harvard University, Boston, MA 02115, USA;
Kyung-Jin Jang
1Wyss Institute for Biologically Inspired Engineering at Harvard University, Boston, MA 02115, USA;
Ville Kujala
1Wyss Institute for Biologically Inspired Engineering at Harvard University, Boston, MA 02115, USA;
3Harvard John A. Paulson School of Engineering and Applied Sciences, Harvard University, Cambridge, MA 02138, USA;
Lian Leng
1Wyss Institute for Biologically Inspired Engineering at Harvard University, Boston, MA 02115, USA;
Robert Mannix
1Wyss Institute for Biologically Inspired Engineering at Harvard University, Boston, MA 02115, USA;
6Vascular Biology Program and Department of Surgery, Boston Children’s Hospital and Harvard Medical School, Boston, MA 02115, USA;
Yuka Milton
1Wyss Institute for Biologically Inspired Engineering at Harvard University, Boston, MA 02115, USA;
Janna Nawroth
1Wyss Institute for Biologically Inspired Engineering at Harvard University, Boston, MA 02115, USA;
3Harvard John A. Paulson School of Engineering and Applied Sciences, Harvard University, Cambridge, MA 02138, USA;
Bret A. Nestor
1Wyss Institute for Biologically Inspired Engineering at Harvard University, Boston, MA 02115, USA;
Carlos F. Ng
1Wyss Institute for Biologically Inspired Engineering at Harvard University, Boston, MA 02115, USA;
Blakely O’Connor
1Wyss Institute for Biologically Inspired Engineering at Harvard University, Boston, MA 02115, USA;
3Harvard John A. Paulson School of Engineering and Applied Sciences, Harvard University, Cambridge, MA 02138, USA;
Tae-Eun Park
1Wyss Institute for Biologically Inspired Engineering at Harvard University, Boston, MA 02115, USA;
Henry Sanchez
1Wyss Institute for Biologically Inspired Engineering at Harvard University, Boston, MA 02115, USA;
Josiah Sliz
1Wyss Institute for Biologically Inspired Engineering at Harvard University, Boston, MA 02115, USA;
Alexandra Sontheimer-Phelps
1Wyss Institute for Biologically Inspired Engineering at Harvard University, Boston, MA 02115, USA;
7Department of Biology, University of Freiburg, Freiburg, Germany;
Ben Swenor
1Wyss Institute for Biologically Inspired Engineering at Harvard University, Boston, MA 02115, USA;
Guy Thompson II
1Wyss Institute for Biologically Inspired Engineering at Harvard University, Boston, MA 02115, USA;
George J. Touloumes
1Wyss Institute for Biologically Inspired Engineering at Harvard University, Boston, MA 02115, USA;
3Harvard John A. Paulson School of Engineering and Applied Sciences, Harvard University, Cambridge, MA 02138, USA;
Zachary Tranchemontagne
1Wyss Institute for Biologically Inspired Engineering at Harvard University, Boston, MA 02115, USA;
Norman Wen
1Wyss Institute for Biologically Inspired Engineering at Harvard University, Boston, MA 02115, USA;
Moran Yadid
1Wyss Institute for Biologically Inspired Engineering at Harvard University, Boston, MA 02115, USA;
3Harvard John A. Paulson School of Engineering and Applied Sciences, Harvard University, Cambridge, MA 02138, USA;
Anthony Bahinski
1Wyss Institute for Biologically Inspired Engineering at Harvard University, Boston, MA 02115, USA;
8GlaxoSmithKline, 1250 S. Collegeville Rd., Collegeville, PA 19426, USA;
Geraldine A. Hamilton
1Wyss Institute for Biologically Inspired Engineering at Harvard University, Boston, MA 02115, USA;
Daniel Levner
1Wyss Institute for Biologically Inspired Engineering at Harvard University, Boston, MA 02115, USA;
Oren Levy
1Wyss Institute for Biologically Inspired Engineering at Harvard University, Boston, MA 02115, USA;
Andrzej Przekwas
2CFD Research Corporation, Huntsville, AL, USA 35806;
Rachelle Prantil-Baun
1Wyss Institute for Biologically Inspired Engineering at Harvard University, Boston, MA 02115, USA;
Kevin K. Parker
1Wyss Institute for Biologically Inspired Engineering at Harvard University, Boston, MA 02115, USA;
3Harvard John A. Paulson School of Engineering and Applied Sciences, Harvard University, Cambridge, MA 02138, USA;
Donald E. Ingber
1Wyss Institute for Biologically Inspired Engineering at Harvard University, Boston, MA 02115, USA;
3Harvard John A. Paulson School of Engineering and Applied Sciences, Harvard University, Cambridge, MA 02138, USA;
6Vascular Biology Program and Department of Surgery, Boston Children’s Hospital and Harvard Medical School, Boston, MA 02115, USA;
- Supplementary Information[supplements/569541_file03.pdf]
- SI Movie 5[supplements/569541_file04.gif]
- SI Movie 1[supplements/569541_file05.mp4]
- SI Movie 2[supplements/569541_file06.mov]
- SI Movie 3[supplements/569541_file07.MOV]
- SI Movie 4[supplements/569541_file08.avi]
![[supplements/569541_file04.gif]](https://www.biorxiv.org/content/biorxiv/early/2019/03/06/569541/DC2/embed/media-2.gif?download=true){kind=link}
Posted March 06, 2019.
A robotic platform for fluidically-linked human body-on-chips experimentation
Richard Novak, Miles Ingram, Susan Clauson, Debarun Das, Aaron Delahanty, Anna Herland, Ben M. Maoz, Sauveur S. F. Jeanty, Mahadevabharath R. Somayaji, Morgan Burt, Elizabeth Calamari, Angeliki Chalkiadaki, Alexander Cho, Youngjae Choe, David Benson Chou, Michael Cronce, Stephanie Dauth, Toni Divic, Jose Fernandez-Alcon, Thomas Ferrante, John Ferrier, Edward A. FitzGerald, Rachel Fleming, Sasan Jalili-Firoozinezhad, Thomas Grevesse, Josue A. Goss, Tiama Hamkins-Indik, Olivier Henry, Chris Hinojosa, Tessa Huffstater, Kyung-Jin Jang, Ville Kujala, Lian Leng, Robert Mannix, Yuka Milton, Janna Nawroth, Bret A. Nestor, Carlos F. Ng, Blakely O’Connor, Tae-Eun Park, Henry Sanchez, Josiah Sliz, Alexandra Sontheimer-Phelps, Ben Swenor, Guy Thompson II, George J. Touloumes, Zachary Tranchemontagne, Norman Wen, Moran Yadid, Anthony Bahinski, Geraldine A. Hamilton, Daniel Levner, Oren Levy, Andrzej Przekwas, Rachelle Prantil-Baun, Kevin K. Parker, Donald E. Ingber
bioRxiv 569541; doi: https://doi.org/10.1101/569541
A robotic platform for fluidically-linked human body-on-chips experimentation
Richard Novak, Miles Ingram, Susan Clauson, Debarun Das, Aaron Delahanty, Anna Herland, Ben M. Maoz, Sauveur S. F. Jeanty, Mahadevabharath R. Somayaji, Morgan Burt, Elizabeth Calamari, Angeliki Chalkiadaki, Alexander Cho, Youngjae Choe, David Benson Chou, Michael Cronce, Stephanie Dauth, Toni Divic, Jose Fernandez-Alcon, Thomas Ferrante, John Ferrier, Edward A. FitzGerald, Rachel Fleming, Sasan Jalili-Firoozinezhad, Thomas Grevesse, Josue A. Goss, Tiama Hamkins-Indik, Olivier Henry, Chris Hinojosa, Tessa Huffstater, Kyung-Jin Jang, Ville Kujala, Lian Leng, Robert Mannix, Yuka Milton, Janna Nawroth, Bret A. Nestor, Carlos F. Ng, Blakely O’Connor, Tae-Eun Park, Henry Sanchez, Josiah Sliz, Alexandra Sontheimer-Phelps, Ben Swenor, Guy Thompson II, George J. Touloumes, Zachary Tranchemontagne, Norman Wen, Moran Yadid, Anthony Bahinski, Geraldine A. Hamilton, Daniel Levner, Oren Levy, Andrzej Przekwas, Rachelle Prantil-Baun, Kevin K. Parker, Donald E. Ingber
bioRxiv 569541; doi: https://doi.org/10.1101/569541
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