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Mutations in pmrB confer cross-resistance to the LptD inhibitor POL7080 and colistin in Pseudomonas aeruginosa
Keith P Romano, Thulasi Warrier, Bradley E Poulsen, Phuong H Nguyen, Alexander R Loftis, Azin Saebi, Bradley L Pentelute, Deborah T Hung
doi: https://doi.org/10.1101/571224
Keith P Romano
aThe Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA
bDepartment of Molecular Biology, Center for Computational and Integrative Biology, Massachusetts General Hospital, Boston, Massachusetts, USA
cDivision of Pulmonary and Critical Care Medicine, Brigham and Women’s Hospital, Boston Massachusetts, USA
Thulasi Warrier
aThe Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA
bDepartment of Molecular Biology, Center for Computational and Integrative Biology, Massachusetts General Hospital, Boston, Massachusetts, USA
Bradley E Poulsen
aThe Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA
bDepartment of Molecular Biology, Center for Computational and Integrative Biology, Massachusetts General Hospital, Boston, Massachusetts, USA
dDepartment of Genetics, Harvard Medical School, Boston, Massachusetts, USA
Phuong H Nguyen
aThe Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA
bDepartment of Molecular Biology, Center for Computational and Integrative Biology, Massachusetts General Hospital, Boston, Massachusetts, USA
dDepartment of Genetics, Harvard Medical School, Boston, Massachusetts, USA
Alexander R Loftis
eDepartment of Chemistry, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA
Azin Saebi
eDepartment of Chemistry, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA
Bradley L Pentelute
eDepartment of Chemistry, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA
Deborah T Hung
aThe Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA
bDepartment of Molecular Biology, Center for Computational and Integrative Biology, Massachusetts General Hospital, Boston, Massachusetts, USA
Article usage
Posted March 08, 2019.
Mutations in pmrB confer cross-resistance to the LptD inhibitor POL7080 and colistin in Pseudomonas aeruginosa
Keith P Romano, Thulasi Warrier, Bradley E Poulsen, Phuong H Nguyen, Alexander R Loftis, Azin Saebi, Bradley L Pentelute, Deborah T Hung
bioRxiv 571224; doi: https://doi.org/10.1101/571224
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