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Cell-type specific innervation of cortical pyramidal cells at their apical tufts

View ORCID ProfileAli Karimi, Jan Odenthal, View ORCID ProfileFlorian Drawitsch, View ORCID ProfileKevin M. Boergens, View ORCID ProfileMoritz Helmstaedter
doi: https://doi.org/10.1101/571695
Ali Karimi
Department of Connectomics, Max Planck Institute for Brain Research, Frankfurt, Germany
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Jan Odenthal
Department of Connectomics, Max Planck Institute for Brain Research, Frankfurt, Germany
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Florian Drawitsch
Department of Connectomics, Max Planck Institute for Brain Research, Frankfurt, Germany
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Kevin M. Boergens
Department of Connectomics, Max Planck Institute for Brain Research, Frankfurt, Germany
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Moritz Helmstaedter
Department of Connectomics, Max Planck Institute for Brain Research, Frankfurt, Germany
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ABSTRACT

We investigated the synaptic innervation of apical tufts of cortical pyramidal cells in a region between layers 1 and 2 using 3-D electron microscopy (3D-EM) applied to four cortical regions in mouse. Across all cortices, we found the relative inhibitory input at the apical dendrite’s main bifurcation to be more than 3-fold stronger for layer 2 pyramidal cells than for all other pyramidal cells. Towards the distal tuft dendrites in upper layer 1, however, the relative inhibitory input was about 2-fold stronger for L5 pyramidal cells than for all others. Only L3 pyramidal cells showed homogeneous inhibitory input density. The inhibitory to excitatory synaptic balance is thus specific for the types of pyramidal cells. Inhibitory axons preferentially innervated either layer 2 or L3/5 apical dendrites, but not both. These findings describe connectomic principles for the control of pyramidal cells at their apical dendrites in the upper layers of the cerebral cortex and point to differential computational properties of layer 2, layer 3 and layer 5 pyramidal cells in cortex.

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The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC-ND 4.0 International license.
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Posted March 15, 2019.
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Cell-type specific innervation of cortical pyramidal cells at their apical tufts
Ali Karimi, Jan Odenthal, Florian Drawitsch, Kevin M. Boergens, Moritz Helmstaedter
bioRxiv 571695; doi: https://doi.org/10.1101/571695
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Cell-type specific innervation of cortical pyramidal cells at their apical tufts
Ali Karimi, Jan Odenthal, Florian Drawitsch, Kevin M. Boergens, Moritz Helmstaedter
bioRxiv 571695; doi: https://doi.org/10.1101/571695

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