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Structural variation targets neurodevelopmental genes and identifies SHANK2 as a tumor suppressor in neuroblastoma
View ORCID ProfileGonzalo Lopez, Karina L. Conkrite, Miriam Doepner, Komal S. Rathi, Apexa Modi, Zalman Vaksman, Lance M. Farra, Eric Hyson, Moataz Noureddine, Jun S. Wei, Malcolm A. Smith, Shahab Asgharzadeh, Robert C. Seeger, Javed Khan, Jaime Guidry Auvil, Daniela S. Gerhard, John M. Maris, Sharon J. Diskin
doi: https://doi.org/10.1101/572248
Gonzalo Lopez
1Division of Oncology, Children’s Hospital of Philadelphia, Philadelphia, PA, USA
2Center for Childhood Cancer Research, Children’s Hospital of Philadelphia, Philadelphia, PA, USA
Karina L. Conkrite
1Division of Oncology, Children’s Hospital of Philadelphia, Philadelphia, PA, USA
2Center for Childhood Cancer Research, Children’s Hospital of Philadelphia, Philadelphia, PA, USA
Miriam Doepner
1Division of Oncology, Children’s Hospital of Philadelphia, Philadelphia, PA, USA
2Center for Childhood Cancer Research, Children’s Hospital of Philadelphia, Philadelphia, PA, USA
Komal S. Rathi
3Department of Biomedical and Health Informatics, Children’s Hospital of Philadelphia, Philadelphia, PA, USA
Apexa Modi
1Division of Oncology, Children’s Hospital of Philadelphia, Philadelphia, PA, USA
2Center for Childhood Cancer Research, Children’s Hospital of Philadelphia, Philadelphia, PA, USA
10Genomics and Computational Biology, Biomedical Graduate Studies, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA
Zalman Vaksman
1Division of Oncology, Children’s Hospital of Philadelphia, Philadelphia, PA, USA
2Center for Childhood Cancer Research, Children’s Hospital of Philadelphia, Philadelphia, PA, USA
3Department of Biomedical and Health Informatics, Children’s Hospital of Philadelphia, Philadelphia, PA, USA
Lance M. Farra
1Division of Oncology, Children’s Hospital of Philadelphia, Philadelphia, PA, USA
2Center for Childhood Cancer Research, Children’s Hospital of Philadelphia, Philadelphia, PA, USA
Eric Hyson
1Division of Oncology, Children’s Hospital of Philadelphia, Philadelphia, PA, USA
2Center for Childhood Cancer Research, Children’s Hospital of Philadelphia, Philadelphia, PA, USA
Moataz Noureddine
1Division of Oncology, Children’s Hospital of Philadelphia, Philadelphia, PA, USA
2Center for Childhood Cancer Research, Children’s Hospital of Philadelphia, Philadelphia, PA, USA
Jun S. Wei
4Oncogenomics Section, Genetics Branch, Center for Cancer Research, National Cancer Institute, Bethesda, MD, USA
Malcolm A. Smith
9Cancer Therapy Evaluation Program, National Cancer Institute, Bethesda, MD, USA
Shahab Asgharzadeh
5Division of Hematology, Oncology and Blood and Marrow Transplantation, Keck School of Medicine of the University of Southern California, Los Angeles, CA, USA
6The Saban Research Institute, Children’s Hospital of Los Angeles, Los Angeles, CA, USA
Robert C. Seeger
5Division of Hematology, Oncology and Blood and Marrow Transplantation, Keck School of Medicine of the University of Southern California, Los Angeles, CA, USA
6The Saban Research Institute, Children’s Hospital of Los Angeles, Los Angeles, CA, USA
Javed Khan
4Oncogenomics Section, Genetics Branch, Center for Cancer Research, National Cancer Institute, Bethesda, MD, USA
Jaime Guidry Auvil
8Office of Cancer Genomics, National Cancer Institute, Bethesda, MD, USA
Daniela S. Gerhard
8Office of Cancer Genomics, National Cancer Institute, Bethesda, MD, USA
John M. Maris
1Division of Oncology, Children’s Hospital of Philadelphia, Philadelphia, PA, USA
2Center for Childhood Cancer Research, Children’s Hospital of Philadelphia, Philadelphia, PA, USA
10Genomics and Computational Biology, Biomedical Graduate Studies, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA
11Abramson Family Cancer Research Institute, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA
Sharon J. Diskin
1Division of Oncology, Children’s Hospital of Philadelphia, Philadelphia, PA, USA
2Center for Childhood Cancer Research, Children’s Hospital of Philadelphia, Philadelphia, PA, USA
3Department of Biomedical and Health Informatics, Children’s Hospital of Philadelphia, Philadelphia, PA, USA
10Genomics and Computational Biology, Biomedical Graduate Studies, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA
11Abramson Family Cancer Research Institute, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA
Article usage
Posted March 13, 2019.
Structural variation targets neurodevelopmental genes and identifies SHANK2 as a tumor suppressor in neuroblastoma
Gonzalo Lopez, Karina L. Conkrite, Miriam Doepner, Komal S. Rathi, Apexa Modi, Zalman Vaksman, Lance M. Farra, Eric Hyson, Moataz Noureddine, Jun S. Wei, Malcolm A. Smith, Shahab Asgharzadeh, Robert C. Seeger, Javed Khan, Jaime Guidry Auvil, Daniela S. Gerhard, John M. Maris, Sharon J. Diskin
bioRxiv 572248; doi: https://doi.org/10.1101/572248
Structural variation targets neurodevelopmental genes and identifies SHANK2 as a tumor suppressor in neuroblastoma
Gonzalo Lopez, Karina L. Conkrite, Miriam Doepner, Komal S. Rathi, Apexa Modi, Zalman Vaksman, Lance M. Farra, Eric Hyson, Moataz Noureddine, Jun S. Wei, Malcolm A. Smith, Shahab Asgharzadeh, Robert C. Seeger, Javed Khan, Jaime Guidry Auvil, Daniela S. Gerhard, John M. Maris, Sharon J. Diskin
bioRxiv 572248; doi: https://doi.org/10.1101/572248
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