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Convergent loss of an EDS1/PAD4 signalling pathway in several plant lineages predicts new components of plant immunity and drought response

EL Baggs, AS Thanki, R O’Grady, C Schudoma, W Haerty, KV Krasileva
doi: https://doi.org/10.1101/572560
EL Baggs
1Earlham Institute, Norwich Research Park, Norwich, NR4 7UZ, United Kingdom
2University of California Berkeley, Berkeley, California, 94720, United States of America
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AS Thanki
1Earlham Institute, Norwich Research Park, Norwich, NR4 7UZ, United Kingdom
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R O’Grady
3The Sainsbury Laboratory, Norwich Research Park, Norwich, NR4 7UH, United Kingdom
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C Schudoma
1Earlham Institute, Norwich Research Park, Norwich, NR4 7UZ, United Kingdom
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W Haerty
1Earlham Institute, Norwich Research Park, Norwich, NR4 7UZ, United Kingdom
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KV Krasileva
1Earlham Institute, Norwich Research Park, Norwich, NR4 7UZ, United Kingdom
2University of California Berkeley, Berkeley, California, 94720, United States of America
3The Sainsbury Laboratory, Norwich Research Park, Norwich, NR4 7UH, United Kingdom
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  • For correspondence: kseniak@berkeley.edu
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Abstract

Plant innate immunity relies on NLR receptors that recognize pathogen derived molecules and activate downstream signalling pathways. We analyzed the variation in copy number of NLR genes across flowering plants, and identified a number of species with a low number of NLRs relative to sister species. Two distinct lineages, one monocot (Lentibulariaceae) and one dicot (Alismatales) encapsulate four species with particularly few NLR genes. In these lineages, loss of NLRs coincided with loss of the well-known downstream immune signalling complex (EDS1-PAD4). When we expanded our analysis across the whole proteomes, we were able to identify other characterized immune genes absent only in Lentibulariaceae and Alismatales. Additionally, we identified a small subset of genes with unknown function convergently lost in all four species. We predicted that some of these genes may have a role in plant immunity. Gene expression analyses confirmed that a group of these genes was differentially expressed under pathogen infection. Another subset of these genes was differentially expressed upon drought providing further evidence of a link between the drought and plant immunity.

Footnotes

  • https://github.com/krasileva-group/Aquatic_NLR

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The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC-ND 4.0 International license.
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Posted November 30, 2019.
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Convergent loss of an EDS1/PAD4 signalling pathway in several plant lineages predicts new components of plant immunity and drought response
EL Baggs, AS Thanki, R O’Grady, C Schudoma, W Haerty, KV Krasileva
bioRxiv 572560; doi: https://doi.org/10.1101/572560
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Convergent loss of an EDS1/PAD4 signalling pathway in several plant lineages predicts new components of plant immunity and drought response
EL Baggs, AS Thanki, R O’Grady, C Schudoma, W Haerty, KV Krasileva
bioRxiv 572560; doi: https://doi.org/10.1101/572560

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