Transient non-integrative nuclear reprogramming promotes multifaceted reversal of aging in human cells

Tapash Jay Sarkar; Marco Quarta; Shravani Mukherjee; Alex Colville; Patrick Paine; Linda Doan; Christopher M. Tran; Constance R. Chu; Steve Horvath; Nidhi Bhutani; Thomas A. Rando; Vittorio Sebastiano

doi:10.1101/573386

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Transient non-integrative nuclear reprogramming promotes multifaceted reversal of aging in human cells

Tapash Jay Sarkar, Marco Quarta, Shravani Mukherjee, Alex Colville, Patrick Paine, Linda Doan, Christopher M. Tran, Constance R. Chu, Steve Horvath, Nidhi Bhutani, Thomas A. Rando, Vittorio Sebastiano

doi: https://doi.org/10.1101/573386

Tapash Jay Sarkar

1Institute for Stem Cell Biology and Regenerative Medicine, Stanford School of Medicine, Stanford, CA 94305

2Department of Obstetrics and Gynecology, Stanford School of Medicine, Stanford, CA 94305.

3Department of Applied Physics, Stanford University School of Humanities and Sciences, CA 94305

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Marco Quarta

4Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA 94305

5Paul F. Glenn Center for the Biology of Aging, Stanford University School of Medicine, Stanford, CA 94305

6Center for Tissue Regeneration, Repair and Restoration, Veterans Affairs Palo Alto Health Care System, Palo Alto, CA 94304

12Molecular Medicine Research Institute, Sunnyvale, CA, 94085

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Shravani Mukherjee

7Department of Orthopedic Surgery, Stanford School of Medicine, Sanford, CA 94305.

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Alex Colville

4Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA 94305

5Paul F. Glenn Center for the Biology of Aging, Stanford University School of Medicine, Stanford, CA 94305

6Center for Tissue Regeneration, Repair and Restoration, Veterans Affairs Palo Alto Health Care System, Palo Alto, CA 94304

8Department of Genetics, Stanford University School of Medicine, Stanford, CA, 94305.

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Patrick Paine

4Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA 94305

5Paul F. Glenn Center for the Biology of Aging, Stanford University School of Medicine, Stanford, CA 94305

6Center for Tissue Regeneration, Repair and Restoration, Veterans Affairs Palo Alto Health Care System, Palo Alto, CA 94304

12Molecular Medicine Research Institute, Sunnyvale, CA, 94085

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Linda Doan

4Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA 94305

5Paul F. Glenn Center for the Biology of Aging, Stanford University School of Medicine, Stanford, CA 94305

6Center for Tissue Regeneration, Repair and Restoration, Veterans Affairs Palo Alto Health Care System, Palo Alto, CA 94304

12Molecular Medicine Research Institute, Sunnyvale, CA, 94085

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Christopher M. Tran

4Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA 94305

5Paul F. Glenn Center for the Biology of Aging, Stanford University School of Medicine, Stanford, CA 94305

6Center for Tissue Regeneration, Repair and Restoration, Veterans Affairs Palo Alto Health Care System, Palo Alto, CA 94304

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Constance R. Chu

7Department of Orthopedic Surgery, Stanford School of Medicine, Sanford, CA 94305.

9VA Palo Alto Health Care System, Palo Alto, CA

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Steve Horvath

10Department of Human Genetics David Geffen School of Medicine, University of California Los Angeles, CA 90095.

11Department of Biostatistics, Fielding School of Public Health, UCLA, CA 90095

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Nidhi Bhutani

7Department of Orthopedic Surgery, Stanford School of Medicine, Sanford, CA 94305.

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Thomas A. Rando

4Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA 94305

5Paul F. Glenn Center for the Biology of Aging, Stanford University School of Medicine, Stanford, CA 94305

6Center for Tissue Regeneration, Repair and Restoration, Veterans Affairs Palo Alto Health Care System, Palo Alto, CA 94304

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Vittorio Sebastiano

1Institute for Stem Cell Biology and Regenerative Medicine, Stanford School of Medicine, Stanford, CA 94305

2Department of Obstetrics and Gynecology, Stanford School of Medicine, Stanford, CA 94305.

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