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Biological age is a universal marker of aging, stress, and frailty

View ORCID ProfileTimothy V. Pyrkov, View ORCID ProfilePeter O. Fedichev
doi: https://doi.org/10.1101/578245
Timothy V. Pyrkov
1Gero LLC, 105064, Nizhny Susalny per. 5/4, Moscow, Russia
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  • ORCID record for Timothy V. Pyrkov
Peter O. Fedichev
1Gero LLC, 105064, Nizhny Susalny per. 5/4, Moscow, Russia
2Moscow Institute of Physics and Technology, 141700, Institutskii per. 9, Dolgoprudny, Moscow Region, Russia
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Summary

We carried out a systematic investigation of supervised learning techniques for biological age modeling. The biological aging acceleration is associated with the remaining health- and life-span. Artificial Deep Neural Networks (DNN) could be used to reduce the error of chronological age predictors, though often at the expense of the ability to distinguish health conditions. Mortality and morbidity hazards models based on survival follow-up data showed the best performance. Alternatively, logistic regression trained to identify chronic diseases was shown to be a good approximation of hazards models when data on survival follow-up times were unavailable. In all models, the biological aging acceleration was associated with disease burden in persons with diagnosed chronic age-related conditions. For healthy individuals, the same quantity was associated with molecular markers of inflammation (such as C-reactive protein), smoking, current physical, and mental health (including sleeping troubles, feeling tired or little interest in doing things). The biological age thus emerged as a universal biomarker of age, frailty and stress for applications involving large scale studies of the effects of longevity drugs on risks of diseases and quality of life.

To be published as Chapter 2 in “Biomarkers of aging”, ed. A. Moskalev, Springer, 2019.

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The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. All rights reserved. No reuse allowed without permission.
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Posted March 14, 2019.
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Biological age is a universal marker of aging, stress, and frailty
Timothy V. Pyrkov, Peter O. Fedichev
bioRxiv 578245; doi: https://doi.org/10.1101/578245
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Biological age is a universal marker of aging, stress, and frailty
Timothy V. Pyrkov, Peter O. Fedichev
bioRxiv 578245; doi: https://doi.org/10.1101/578245

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