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Circuits that encode and predict alcohol associated preference

View ORCID ProfileKristin M. Scaplen, View ORCID ProfileMustafa Talay, Sarah Salamon, View ORCID ProfileKavin M. Nuñez, Amanda G. Waterman, Sydney Gang, Sophia L. Song, View ORCID ProfileGilad Barnea, View ORCID ProfileKarla R. Kaun
doi: https://doi.org/10.1101/578401
Kristin M. Scaplen
aDepartment of Neuroscience, Brown University, Providence, RI 02912, USA
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Mustafa Talay
bHoward Hughes Medical Institute, Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA 02138, USA
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Sarah Salamon
cDepartment of Pharmacology, University of Cologne, Faculty of Medical and University Hospital Cologne, Germany
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Kavin M. Nuñez
dDepartment of Molecular Pharmacology and Physiology, Brown University, Providence, RI 02912, USA
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Amanda G. Waterman
aDepartment of Neuroscience, Brown University, Providence, RI 02912, USA
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Sydney Gang
eDepartment of Biochemistry, Brown University, Providence, RI 02912, USA
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Sophia L. Song
aDepartment of Neuroscience, Brown University, Providence, RI 02912, USA
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Gilad Barnea
aDepartment of Neuroscience, Brown University, Providence, RI 02912, USA
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Karla R. Kaun
aDepartment of Neuroscience, Brown University, Providence, RI 02912, USA
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  • For correspondence: karla_kaun@brown.edu
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Abstract

Substance use disorders are chronic relapsing disorders often impelled by enduring memories and persistent cravings. Alcohol, as well as other addictive substances, remolds neural circuits important for memory to establish obstinate preference despite aversive consequences. How pertinent circuits are selected and shaped to result in these unchanging, inflexible memories is unclear. Using neurogenetic tools available in Drosophila melanogaster we define how circuits required for alcohol associated preference shift from population level dopaminergic activation to select dopamine neurons that predict behavioral choice. During memory expression, these dopamine neurons directly, and indirectly via the mushroom body (MB), modulate the activity of interconnected glutamatergic and cholinergic output neurons. Transsynaptic tracing of these output neurons revealed at least two regions of convergence: 1) a center of memory consolidation within the MB implicated in arousal, and 2) a structure outside the MB implicated in integration of naïve and learned responses. These findings provide a circuit framework through which dopamine neuron activation shifts from reward delivery to cue onset, and provides insight into the inflexible, maladaptive nature of alcohol associated memories.

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Posted March 15, 2019.
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Circuits that encode and predict alcohol associated preference
Kristin M. Scaplen, Mustafa Talay, Sarah Salamon, Kavin M. Nuñez, Amanda G. Waterman, Sydney Gang, Sophia L. Song, Gilad Barnea, Karla R. Kaun
bioRxiv 578401; doi: https://doi.org/10.1101/578401
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Circuits that encode and predict alcohol associated preference
Kristin M. Scaplen, Mustafa Talay, Sarah Salamon, Kavin M. Nuñez, Amanda G. Waterman, Sydney Gang, Sophia L. Song, Gilad Barnea, Karla R. Kaun
bioRxiv 578401; doi: https://doi.org/10.1101/578401

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