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Genomic signatures of extreme body size divergence in baboons

View ORCID ProfileKenneth L. Chiou, View ORCID ProfileChristina M. Bergey, Andrew S. Burrell, Todd R. Disotell, View ORCID ProfileJeffrey Rogers, Clifford J. Jolly, Jane E. Phillips-Conroy
doi: https://doi.org/10.1101/578740
Kenneth L. Chiou
1Department of Anthropology, Washington University, St. Louis, MO 63130, USA
2Department of Psychology, University of Washington, Seattle, WA 98195, USA
3Nathan Shock Center of Excellence in the Basic Biology of Aging, University of Washington, Seattle, WA 98195, USA
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Christina M. Bergey
4Department of Anthropology, New York University, New York, NY 10003, USA
5New York Consortium in Evolutionary Primatology, New York, NY, USA
6Department of Anthropology, Pennsylvania State University, University Park, PA 16802, USA
7Department of Biology, Pennsylvania State University, University Park, PA 16802, USA
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Andrew S. Burrell
4Department of Anthropology, New York University, New York, NY 10003, USA
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Todd R. Disotell
4Department of Anthropology, New York University, New York, NY 10003, USA
5New York Consortium in Evolutionary Primatology, New York, NY, USA
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Jeffrey Rogers
8Human Genome Sequencing Center, Baylor College of Medicine, Houston, TX 77030, USA
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Clifford J. Jolly
4Department of Anthropology, New York University, New York, NY 10003, USA
5New York Consortium in Evolutionary Primatology, New York, NY, USA
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Jane E. Phillips-Conroy
1Department of Anthropology, Washington University, St. Louis, MO 63130, USA
9Department of Neuroscience, Washington University School of Medicine, St. Louis, MO 63110, USA
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Abstract

Kinda and gray-footed chacma baboons occupy opposite extremes of the body size distribution in extant baboons (genus Papio). In order to detect signatures of natural selection in these two species, we genotyped 24,790 genome-wide autosomal SNPs from populations of Zambian baboons using double digest RADseq. We scanned the genome for evidence of selection by identifying regions with extreme differentiation between populations. We find evidence of selection on body size influencing multiple genes in one or both species, including FGF1, ATXN2, and PRKCE. We also find an enriched signal of selection associated with biological processes involved in multicellular organism growth and development, cell proliferation and cell growth, nutrient metabolism, and chondrocyte differentiation. Finally, we find that selection has impacted components of the CCKR signaling pathway, which regulates food intake and metabolism, and the JAK/STAT signaling pathway, which mediates the effect of cytokine signals on processes including epiphyseal chondrocyte proliferation essential for longitudinal bone growth. Our findings highlight promising avenues for future studies disentangling the genetic architecture of body size in primates including humans.

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Posted March 16, 2019.
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Genomic signatures of extreme body size divergence in baboons
Kenneth L. Chiou, Christina M. Bergey, Andrew S. Burrell, Todd R. Disotell, Jeffrey Rogers, Clifford J. Jolly, Jane E. Phillips-Conroy
bioRxiv 578740; doi: https://doi.org/10.1101/578740
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Genomic signatures of extreme body size divergence in baboons
Kenneth L. Chiou, Christina M. Bergey, Andrew S. Burrell, Todd R. Disotell, Jeffrey Rogers, Clifford J. Jolly, Jane E. Phillips-Conroy
bioRxiv 578740; doi: https://doi.org/10.1101/578740

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