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Phase-specific manipulation of neural oscillations by transcranial alternating current stimulation

Marina Fiene, Bettina C. Schwab, Jonas Misselhorn, Christoph S. Herrmann, Till R. Schneider, Andreas K. Engel
doi: https://doi.org/10.1101/579631
Marina Fiene
1Department of Neurophysiology and Pathophysiology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany
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  • For correspondence: m.fiene@uke.de
Bettina C. Schwab
1Department of Neurophysiology and Pathophysiology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany
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Jonas Misselhorn
1Department of Neurophysiology and Pathophysiology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany
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Christoph S. Herrmann
2Experimental Psychology Lab, Department of Psychology, Cluster of Excellence “Hearing4all”, European Medical School, Carl von Ossietzky University Oldenburg, Oldenburg, Germany
3Research Center Neurosensory Science, Carl von Ossietzky University Oldenburg, Oldenburg, Germany
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Till R. Schneider
1Department of Neurophysiology and Pathophysiology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany
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Andreas K. Engel
1Department of Neurophysiology and Pathophysiology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany
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Abstract

Oscillatory phase has been proposed as a key parameter defining the spatiotemporal structure of neural activity. To enhance our understanding of brain rhythms, phase-specific modulation of oscillations by transcranial alternating current stimulation (tACS) emerged as a promising approach. However, the effectiveness of tACS is still critically debated. Here, we investigated the phase-specificity of tACS effects on visually evoked steady state responses (SSRs). We observed that the phase shift between flicker and tACS modulates evoked SSR amplitudes. Neural sources of phase-specific effects were localized in the parieto-occipital cortex within flicker-aligned regions. Importantly, tACS effects were stronger in subjects with weaker locking of neural responses to flicker phase. Overall, our data provide evidence for a phase-specific modulation of oscillations by tACS, since SSR amplitude changes can only result from phase-dependent interactions with applied electric fields. This finding corroborates the physiological efficacy of tACS and highlights its potential for controlled modulations of brain signals.

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Posted July 18, 2019.
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Phase-specific manipulation of neural oscillations by transcranial alternating current stimulation
Marina Fiene, Bettina C. Schwab, Jonas Misselhorn, Christoph S. Herrmann, Till R. Schneider, Andreas K. Engel
bioRxiv 579631; doi: https://doi.org/10.1101/579631
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Phase-specific manipulation of neural oscillations by transcranial alternating current stimulation
Marina Fiene, Bettina C. Schwab, Jonas Misselhorn, Christoph S. Herrmann, Till R. Schneider, Andreas K. Engel
bioRxiv 579631; doi: https://doi.org/10.1101/579631

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