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Restored alveolar epithelial differentiation and reversed human lung fibrosis upon Notch inhibition
View ORCID ProfileRM Wasnick, View ORCID ProfileM Korfei, K Piskulak, I Henneke, View ORCID ProfileJ Wilhelm, View ORCID ProfileP Mahavadi, View ORCID ProfileD von der Beck, M Koch, I Shalashova, View ORCID ProfileO Klymenko, L Fink, H Witt, View ORCID ProfileH Hackstein, E El Agha, S Bellusci, W Klepetko, M Königshoff, O Eickelberg, T Braun, View ORCID ProfileW Seeger, C Ruppert, A Guenther
doi: https://doi.org/10.1101/580498
RM Wasnick
1Department of Internal Medicine, Justus-Liebig-University Giessen, 35392 Giessen, Germany
M Korfei
1Department of Internal Medicine, Justus-Liebig-University Giessen, 35392 Giessen, Germany
K Piskulak
1Department of Internal Medicine, Justus-Liebig-University Giessen, 35392 Giessen, Germany
I Henneke
1Department of Internal Medicine, Justus-Liebig-University Giessen, 35392 Giessen, Germany
J Wilhelm
1Department of Internal Medicine, Justus-Liebig-University Giessen, 35392 Giessen, Germany
10Cardio-Pulmonary Institute (CPI), 35392 Giessen, Germany
11University of Giessen and Marburg Lung Center (UGMLC); German Center for Lung Research (DZL), 35392 Giessen, Germany
P Mahavadi
1Department of Internal Medicine, Justus-Liebig-University Giessen, 35392 Giessen, Germany
9Excellence Cluster Cardio-Pulmonary System (ECCPS), 35392 Giessen, Germany
10Cardio-Pulmonary Institute (CPI), 35392 Giessen, Germany
11University of Giessen and Marburg Lung Center (UGMLC); German Center for Lung Research (DZL), 35392 Giessen, Germany
D von der Beck
1Department of Internal Medicine, Justus-Liebig-University Giessen, 35392 Giessen, Germany
M Koch
1Department of Internal Medicine, Justus-Liebig-University Giessen, 35392 Giessen, Germany
I Shalashova
1Department of Internal Medicine, Justus-Liebig-University Giessen, 35392 Giessen, Germany
O Klymenko
1Department of Internal Medicine, Justus-Liebig-University Giessen, 35392 Giessen, Germany
L Fink
2Institute of Pathology, UEGP, 35578 Wetzlar, Germany
11University of Giessen and Marburg Lung Center (UGMLC); German Center for Lung Research (DZL), 35392 Giessen, Germany
H Witt
3Department of Pediatrics, Technical University Munich, 85354 Freising, Germany
H Hackstein
4Department of Clinical Immunology and Transfusion Medicine, 35392 Giessen, Germany
11University of Giessen and Marburg Lung Center (UGMLC); German Center for Lung Research (DZL), 35392 Giessen, Germany
E El Agha
1Department of Internal Medicine, Justus-Liebig-University Giessen, 35392 Giessen, Germany
10Cardio-Pulmonary Institute (CPI), 35392 Giessen, Germany
11University of Giessen and Marburg Lung Center (UGMLC); German Center for Lung Research (DZL), 35392 Giessen, Germany
S Bellusci
1Department of Internal Medicine, Justus-Liebig-University Giessen, 35392 Giessen, Germany
9Excellence Cluster Cardio-Pulmonary System (ECCPS), 35392 Giessen, Germany
10Cardio-Pulmonary Institute (CPI), 35392 Giessen, Germany
11University of Giessen and Marburg Lung Center (UGMLC); German Center for Lung Research (DZL), 35392 Giessen, Germany
W Klepetko
5Department of Thoracic Surgery, Vienna General Hospital, 1090 Vienna, Austria
M Königshoff
6Comprehensive Pneumology Center, Research Unit Lung Repair and Regeneration, Helmholtz Center Munich, Ludwig Maximilians University Munich; 81377 Munich, Germany
14Department of Medicine, Division of Pulmonary Sciences and Critical Care Medicine, University of Colorado, United States
O Eickelberg
6Comprehensive Pneumology Center, Research Unit Lung Repair and Regeneration, Helmholtz Center Munich, Ludwig Maximilians University Munich; 81377 Munich, Germany
13Division of Respiratory Sciences and Critical Care Medicine, University of Colorado, United States
T Braun
7Max-Planck-Institute for Heart and Lung Research, 61231 Bad Nauheim, Germany
9Excellence Cluster Cardio-Pulmonary System (ECCPS), 35392 Giessen, Germany
10Cardio-Pulmonary Institute (CPI), 35392 Giessen, Germany
11University of Giessen and Marburg Lung Center (UGMLC); German Center for Lung Research (DZL), 35392 Giessen, Germany
W Seeger
1Department of Internal Medicine, Justus-Liebig-University Giessen, 35392 Giessen, Germany
7Max-Planck-Institute for Heart and Lung Research, 61231 Bad Nauheim, Germany
9Excellence Cluster Cardio-Pulmonary System (ECCPS), 35392 Giessen, Germany
10Cardio-Pulmonary Institute (CPI), 35392 Giessen, Germany
11University of Giessen and Marburg Lung Center (UGMLC); German Center for Lung Research (DZL), 35392 Giessen, Germany
C Ruppert
1Department of Internal Medicine, Justus-Liebig-University Giessen, 35392 Giessen, Germany
9Excellence Cluster Cardio-Pulmonary System (ECCPS), 35392 Giessen, Germany
11University of Giessen and Marburg Lung Center (UGMLC); German Center for Lung Research (DZL), 35392 Giessen, Germany
12European IPF Registry / Biobank, 35392 Giessen, Germany
A Guenther
1Department of Internal Medicine, Justus-Liebig-University Giessen, 35392 Giessen, Germany
8Lung Clinic Waldhof-Elgershausen, 35753 Greifenstein, Germany
9Excellence Cluster Cardio-Pulmonary System (ECCPS), 35392 Giessen, Germany
10Cardio-Pulmonary Institute (CPI), 35392 Giessen, Germany
11University of Giessen and Marburg Lung Center (UGMLC); German Center for Lung Research (DZL), 35392 Giessen, Germany
12European IPF Registry / Biobank, 35392 Giessen, Germany
Posted March 23, 2019.
Restored alveolar epithelial differentiation and reversed human lung fibrosis upon Notch inhibition
RM Wasnick, M Korfei, K Piskulak, I Henneke, J Wilhelm, P Mahavadi, D von der Beck, M Koch, I Shalashova, O Klymenko, L Fink, H Witt, H Hackstein, E El Agha, S Bellusci, W Klepetko, M Königshoff, O Eickelberg, T Braun, W Seeger, C Ruppert, A Guenther
bioRxiv 580498; doi: https://doi.org/10.1101/580498
Restored alveolar epithelial differentiation and reversed human lung fibrosis upon Notch inhibition
RM Wasnick, M Korfei, K Piskulak, I Henneke, J Wilhelm, P Mahavadi, D von der Beck, M Koch, I Shalashova, O Klymenko, L Fink, H Witt, H Hackstein, E El Agha, S Bellusci, W Klepetko, M Königshoff, O Eickelberg, T Braun, W Seeger, C Ruppert, A Guenther
bioRxiv 580498; doi: https://doi.org/10.1101/580498
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