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Presynaptic boutons that contain mitochondria are more stable

View ORCID ProfileRobert M. Lees, James D. Johnson, View ORCID ProfileMichael C. Ashby
doi: https://doi.org/10.1101/580530
Robert M. Lees
1School of Physiology, Pharmacology and Neuroscience, University of Bristol, Biomedical Sciences Building, University Walk, Bristol BS8 1TD, UK
2Department of Physiology, Anatomy and Genetics, University of Oxford, Sherrington Building, Sherrington Road, Oxford OX1 3PT, UK
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James D. Johnson
1School of Physiology, Pharmacology and Neuroscience, University of Bristol, Biomedical Sciences Building, University Walk, Bristol BS8 1TD, UK
3John Edward Porter Neuroscience Research Center (Building 35), National Institutes of Health, 35 Convent Drive, Bethesda, MD 20814, US
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Michael C. Ashby
1School of Physiology, Pharmacology and Neuroscience, University of Bristol, Biomedical Sciences Building, University Walk, Bristol BS8 1TD, UK
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  • For correspondence: m.c.ashby@bristol.ac.uk
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Abstract

Addition and removal of presynaptic terminals reconfigures neuronal circuits of the mammalian neocortex, but little is known about how this presynaptic structural plasticity is controlled. Since mitochondria can regulate presynaptic function, we investigated whether the presence of axonal mitochondria relates to structural plasticity of presynaptic boutons in mouse neocortex. We found that the overall density of axonal mitochondria did not appear to influence loss and gain of boutons. However, positioning of mitochondria at individual presynaptic sites did relate to increased stability of those boutons. In line with this, synaptic localisation of mitochondria increased as boutons aged and showed differing patterns of localisation at en passant and terminaux boutons. These results suggest that mitochondria accumulate locally at boutons over time to increase bouton stability.

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The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY 4.0 International license.
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Posted March 18, 2019.
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Presynaptic boutons that contain mitochondria are more stable
Robert M. Lees, James D. Johnson, Michael C. Ashby
bioRxiv 580530; doi: https://doi.org/10.1101/580530
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Presynaptic boutons that contain mitochondria are more stable
Robert M. Lees, James D. Johnson, Michael C. Ashby
bioRxiv 580530; doi: https://doi.org/10.1101/580530

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