Skip to main content
bioRxiv
  • Home
  • About
  • Submit
  • ALERTS / RSS
Advanced Search
Confirmatory Results

Familial influences on Neuroticism and Education in the UK Biobank

View ORCID ProfileR. Cheesman, View ORCID ProfileJ. Coleman, View ORCID ProfileC. Rayner, View ORCID ProfileK.L. Purves, View ORCID ProfileG. Morneau-Vaillancourt, View ORCID ProfileK. Glanville, View ORCID ProfileS.W. Choi, View ORCID ProfileG. Breen, View ORCID ProfileT.C. Eley
doi: https://doi.org/10.1101/582627
R. Cheesman
1Social Genetic & Developmental Psychiatry Centre, Institute of Psychiatry, Psychology & Neuroscience, King’s College London, UK
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for R. Cheesman
J. Coleman
1Social Genetic & Developmental Psychiatry Centre, Institute of Psychiatry, Psychology & Neuroscience, King’s College London, UK
2NIHR Biomedical Research Centre for Mental Health; South London and Maudsley NHS Trust, UK
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for J. Coleman
C. Rayner
1Social Genetic & Developmental Psychiatry Centre, Institute of Psychiatry, Psychology & Neuroscience, King’s College London, UK
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for C. Rayner
K.L. Purves
1Social Genetic & Developmental Psychiatry Centre, Institute of Psychiatry, Psychology & Neuroscience, King’s College London, UK
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for K.L. Purves
G. Morneau-Vaillancourt
3Research Unit on Children Psychosocial Maladjustment, Laval University, Canada
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for G. Morneau-Vaillancourt
K. Glanville
1Social Genetic & Developmental Psychiatry Centre, Institute of Psychiatry, Psychology & Neuroscience, King’s College London, UK
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for K. Glanville
S.W. Choi
1Social Genetic & Developmental Psychiatry Centre, Institute of Psychiatry, Psychology & Neuroscience, King’s College London, UK
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for S.W. Choi
G. Breen
1Social Genetic & Developmental Psychiatry Centre, Institute of Psychiatry, Psychology & Neuroscience, King’s College London, UK
2NIHR Biomedical Research Centre for Mental Health; South London and Maudsley NHS Trust, UK
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for G. Breen
T.C. Eley
1Social Genetic & Developmental Psychiatry Centre, Institute of Psychiatry, Psychology & Neuroscience, King’s College London, UK
2NIHR Biomedical Research Centre for Mental Health; South London and Maudsley NHS Trust, UK
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for T.C. Eley
  • Abstract
  • Full Text
  • Info/History
  • Metrics
  • Supplementary material
  • Preview PDF
Loading

Abstract

Genome-wide studies often exclude family members, even though they are a valuable source of information. We identified parent-offspring pairs, siblings and couples in the UK Biobank and implemented a family-based DNA-derived heritability method to capture additional genetic effects and multiple sources of environmental influence on neuroticism and years of education. Compared to estimates from unrelated individuals, heritability increased from 10% to 27% and from 19% to 57% for neuroticism and education respectively by including family-based genetic effects. We detected no family environmental influences on neuroticism, but years of education was substantially influenced by couple similarity (38%). Overall, our genetic and environmental estimates closely replicate previous findings from an independent sample, but more research is required to dissect contributions to the additional heritability, particularly rare and structural genetic effects and residual environmental confounding. The latter is especially relevant for years of education, a highly socially-contingent variable, for which our heritability estimate is at the upper end of twin estimates in the literature. Family-based genetic effects narrow the gap between twin and DNA-based heritability methods, and could be harnessed to improve polygenic prediction.

Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC-ND 4.0 International license.
Back to top
PreviousNext
Posted March 20, 2019.
Download PDF

Supplementary Material

Email

Thank you for your interest in spreading the word about bioRxiv.

NOTE: Your email address is requested solely to identify you as the sender of this article.

Enter multiple addresses on separate lines or separate them with commas.
Familial influences on Neuroticism and Education in the UK Biobank
(Your Name) has forwarded a page to you from bioRxiv
(Your Name) thought you would like to see this page from the bioRxiv website.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Share
Familial influences on Neuroticism and Education in the UK Biobank
R. Cheesman, J. Coleman, C. Rayner, K.L. Purves, G. Morneau-Vaillancourt, K. Glanville, S.W. Choi, G. Breen, T.C. Eley
bioRxiv 582627; doi: https://doi.org/10.1101/582627
Reddit logo Twitter logo Facebook logo LinkedIn logo Mendeley logo
Citation Tools
Familial influences on Neuroticism and Education in the UK Biobank
R. Cheesman, J. Coleman, C. Rayner, K.L. Purves, G. Morneau-Vaillancourt, K. Glanville, S.W. Choi, G. Breen, T.C. Eley
bioRxiv 582627; doi: https://doi.org/10.1101/582627

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
  • Tweet Widget
  • Facebook Like
  • Google Plus One

Subject Area

  • Genomics
Subject Areas
All Articles
  • Animal Behavior and Cognition (4655)
  • Biochemistry (10307)
  • Bioengineering (7618)
  • Bioinformatics (26200)
  • Biophysics (13453)
  • Cancer Biology (10624)
  • Cell Biology (15348)
  • Clinical Trials (138)
  • Developmental Biology (8453)
  • Ecology (12760)
  • Epidemiology (2067)
  • Evolutionary Biology (16773)
  • Genetics (11361)
  • Genomics (15405)
  • Immunology (10554)
  • Microbiology (25060)
  • Molecular Biology (10162)
  • Neuroscience (54128)
  • Paleontology (398)
  • Pathology (1655)
  • Pharmacology and Toxicology (2877)
  • Physiology (4314)
  • Plant Biology (9204)
  • Scientific Communication and Education (1582)
  • Synthetic Biology (2543)
  • Systems Biology (6753)
  • Zoology (1453)