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Scalable generalized linear mixed model for region-based association tests in large biobanks and cohorts
View ORCID ProfileWei Zhou, Jonas B. Nielsen, View ORCID ProfileLars G. Fritsche, Jonathon LeFaive, Sarah A. Gagliano Taliun, Wenjian Bi, Maiken E. Gabrielsen, Mark J. Daly, Benjamin M. Neale, Kristian Hveem, Goncalo R. Abecasis, View ORCID ProfileCristen J. Willer, Seunggeun Lee
doi: https://doi.org/10.1101/583278
Wei Zhou
1Center for Statistical Genetics, University of Michigan School of Public Health, Ann Arbor, Michigan, USA
2Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, Massachusetts, USA
3Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, Massachusetts, USA
4Stanley Center for Psychiatric Research, Broad Institute of Harvard and MIT, Cambridge, Massachusetts, USA
Jonas B. Nielsen
5Department of Internal Medicine, Division of Cardiology, University of Michigan Medical School, Ann Arbor, Michigan, USA
Lars G. Fritsche
1Center for Statistical Genetics, University of Michigan School of Public Health, Ann Arbor, Michigan, USA
6Department of Biostatistics, University of Michigan School of Public Health, Ann Arbor, Michigan, USA
Jonathon LeFaive
1Center for Statistical Genetics, University of Michigan School of Public Health, Ann Arbor, Michigan, USA
6Department of Biostatistics, University of Michigan School of Public Health, Ann Arbor, Michigan, USA
Sarah A. Gagliano Taliun
1Center for Statistical Genetics, University of Michigan School of Public Health, Ann Arbor, Michigan, USA
6Department of Biostatistics, University of Michigan School of Public Health, Ann Arbor, Michigan, USA
Wenjian Bi
1Center for Statistical Genetics, University of Michigan School of Public Health, Ann Arbor, Michigan, USA
6Department of Biostatistics, University of Michigan School of Public Health, Ann Arbor, Michigan, USA
Maiken E. Gabrielsen
7K.G. Jebsen Center for Genetic Epidemiology, Department of Public Health and Nursing, NTNU, Norwegian University of Science and Technology, NTNU, Norway
Mark J. Daly
2Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, Massachusetts, USA
3Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, Massachusetts, USA
4Stanley Center for Psychiatric Research, Broad Institute of Harvard and MIT, Cambridge, Massachusetts, USA
Benjamin M. Neale
2Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, Massachusetts, USA
3Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, Massachusetts, USA
4Stanley Center for Psychiatric Research, Broad Institute of Harvard and MIT, Cambridge, Massachusetts, USA
Kristian Hveem
7K.G. Jebsen Center for Genetic Epidemiology, Department of Public Health and Nursing, NTNU, Norwegian University of Science and Technology, NTNU, Norway
8HUNT Research Centre, Department of Public Health and Nursing, Norwegian University of Science and Technology, NTNU, 7600 Levanger, Norway
Goncalo R. Abecasis
1Center for Statistical Genetics, University of Michigan School of Public Health, Ann Arbor, Michigan, USA
6Department of Biostatistics, University of Michigan School of Public Health, Ann Arbor, Michigan, USA
Cristen J. Willer
5Department of Internal Medicine, Division of Cardiology, University of Michigan Medical School, Ann Arbor, Michigan, USA
9Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, Michigan, USA
10Department of Human Genetics, University of Michigan Medical School, Ann Arbor, Michigan, USA
Seunggeun Lee
1Center for Statistical Genetics, University of Michigan School of Public Health, Ann Arbor, Michigan, USA
6Department of Biostatistics, University of Michigan School of Public Health, Ann Arbor, Michigan, USA
Posted March 20, 2019.
Scalable generalized linear mixed model for region-based association tests in large biobanks and cohorts
Wei Zhou, Jonas B. Nielsen, Lars G. Fritsche, Jonathon LeFaive, Sarah A. Gagliano Taliun, Wenjian Bi, Maiken E. Gabrielsen, Mark J. Daly, Benjamin M. Neale, Kristian Hveem, Goncalo R. Abecasis, Cristen J. Willer, Seunggeun Lee
bioRxiv 583278; doi: https://doi.org/10.1101/583278
Scalable generalized linear mixed model for region-based association tests in large biobanks and cohorts
Wei Zhou, Jonas B. Nielsen, Lars G. Fritsche, Jonathon LeFaive, Sarah A. Gagliano Taliun, Wenjian Bi, Maiken E. Gabrielsen, Mark J. Daly, Benjamin M. Neale, Kristian Hveem, Goncalo R. Abecasis, Cristen J. Willer, Seunggeun Lee
bioRxiv 583278; doi: https://doi.org/10.1101/583278
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