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Learning hierarchical sequence representations across human cortex and hippocampus

View ORCID ProfileSimon Henin, Nicholas B. Turk-Browne, Daniel Friedman, Anli Liu, Patricia Dugan, Adeen Flinker, Werner Doyle, Orrin Devinsky, Lucia Melloni
doi: https://doi.org/10.1101/583856
Simon Henin
1New York University Comprehensive Epilepsy Center, 223 34th Street, New York, NY 10016, USA
2Department of Neurology, New York University School of Medicine, 240 East 38th Street, 20th Floor, New York, NY 10016, USA
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  • ORCID record for Simon Henin
  • For correspondence: simon.henin@nyumc.org
Nicholas B. Turk-Browne
3Department of Psychology, Yale University
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Daniel Friedman
1New York University Comprehensive Epilepsy Center, 223 34th Street, New York, NY 10016, USA
2Department of Neurology, New York University School of Medicine, 240 East 38th Street, 20th Floor, New York, NY 10016, USA
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Anli Liu
1New York University Comprehensive Epilepsy Center, 223 34th Street, New York, NY 10016, USA
2Department of Neurology, New York University School of Medicine, 240 East 38th Street, 20th Floor, New York, NY 10016, USA
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Patricia Dugan
1New York University Comprehensive Epilepsy Center, 223 34th Street, New York, NY 10016, USA
2Department of Neurology, New York University School of Medicine, 240 East 38th Street, 20th Floor, New York, NY 10016, USA
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Adeen Flinker
1New York University Comprehensive Epilepsy Center, 223 34th Street, New York, NY 10016, USA
2Department of Neurology, New York University School of Medicine, 240 East 38th Street, 20th Floor, New York, NY 10016, USA
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Werner Doyle
1New York University Comprehensive Epilepsy Center, 223 34th Street, New York, NY 10016, USA
2Department of Neurology, New York University School of Medicine, 240 East 38th Street, 20th Floor, New York, NY 10016, USA
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Orrin Devinsky
1New York University Comprehensive Epilepsy Center, 223 34th Street, New York, NY 10016, USA
2Department of Neurology, New York University School of Medicine, 240 East 38th Street, 20th Floor, New York, NY 10016, USA
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Lucia Melloni
1New York University Comprehensive Epilepsy Center, 223 34th Street, New York, NY 10016, USA
2Department of Neurology, New York University School of Medicine, 240 East 38th Street, 20th Floor, New York, NY 10016, USA
4Department of Neuroscience, Max Planck Institute for Empirical Aesthetics, Grüneburgweg 14, 60322, Frankfurt am Main, Germany
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ABSTRACT

Sensory input arrives in continuous sequences that humans experience as units, e.g., words and events. The brain’s ability to discover extrinsic regularities is called statistical learning. Structure can be represented at multiple levels, including transitional probabilities, ordinal position, and identity of units. To investigate sequence encoding in cortex and hippocampus, we recorded from intracranial electrodes in human subjects as they were exposed to auditory and visual sequences containing temporal regularities. We find neural tracking of regularities within minutes, with characteristic profiles across brain areas. Early processing tracked lower-level features (e.g., syllables) and learned units (e.g., words); while later processing tracked only learned units. Learning rapidly shaped neural representations, with a gradient of complexity from early brain areas encoding transitional probability, to associative regions and hippocampus encoding ordinal position and identity of units. These findings indicate the existence of multiple, parallel computational systems for sequence learning across hierarchically organized cortico-hippocampal circuits.

Competing Interest Statement

The authors have declared no competing interest.

Footnotes

  • ↵* Lead Contact Simon Henin (simon.henin{at}nyumc.org) and Lucia Melloni (lucia.melloni{at}ae.mpg.de)

  • New results are presented from hippocampus; The title has been updated to reflect the broader scope of the article and results. Supplemental files updated

Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. All rights reserved. No reuse allowed without permission.
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Posted May 11, 2020.
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Learning hierarchical sequence representations across human cortex and hippocampus
Simon Henin, Nicholas B. Turk-Browne, Daniel Friedman, Anli Liu, Patricia Dugan, Adeen Flinker, Werner Doyle, Orrin Devinsky, Lucia Melloni
bioRxiv 583856; doi: https://doi.org/10.1101/583856
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Learning hierarchical sequence representations across human cortex and hippocampus
Simon Henin, Nicholas B. Turk-Browne, Daniel Friedman, Anli Liu, Patricia Dugan, Adeen Flinker, Werner Doyle, Orrin Devinsky, Lucia Melloni
bioRxiv 583856; doi: https://doi.org/10.1101/583856

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