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Whole-genome and RNA sequencing reveal variation and transcriptomic coordination in the developing human prefrontal cortex
View ORCID ProfileDonna M. Werling, View ORCID ProfileSirisha Pochareddy, View ORCID ProfileJinmyung Choi, View ORCID ProfileJoon-Yong An, View ORCID ProfileBrooke Sheppard, Minshi Peng, Zhen Li, Claudia Dastmalchi, Gabriel Santpere, Andre M. M. Sousa, View ORCID ProfileAndrew T. N. Tebbenkamp, Navjot Kaur, View ORCID ProfileForrest O. Gulden, View ORCID ProfileMichael S. Breen, Lindsay Liang, Michael C. Gilson, Xuefang Zhao, Shan Dong, View ORCID ProfileLambertus Klei, View ORCID ProfileA. Ercument Cicek, View ORCID ProfileJoseph D. Buxbaum, View ORCID ProfileHoma Adle-Biassette, View ORCID ProfileJean-Leon Thomas, View ORCID ProfileKimberly A. Aldinger, Diana R. O’Day, Ian A. Glass, Noah A. Zaitlen, View ORCID ProfileMichael E. Talkowski, View ORCID ProfileKathryn Roeder, View ORCID ProfileMatthew W. State, View ORCID ProfileBernie Devlin, View ORCID ProfileStephan J. Sanders, View ORCID ProfileNenad Sestan
doi: https://doi.org/10.1101/585430
Donna M. Werling
1Department of Psychiatry, UCSF Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, CA 94158, USA
Sirisha Pochareddy
2Department of Neuroscience and Kavli Institute for Neuroscience, Yale School of Medicine, New Haven, CT 06510, USA
Jinmyung Choi
2Department of Neuroscience and Kavli Institute for Neuroscience, Yale School of Medicine, New Haven, CT 06510, USA
Joon-Yong An
1Department of Psychiatry, UCSF Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, CA 94158, USA
3Department of Integrated Biomedical and Life Science, Korea University, Seoul, Republic of Korea
4School of Biosystem and Biomedical Science, College of Health Science, Korea University, Seoul, Republic of Korea
Brooke Sheppard
1Department of Psychiatry, UCSF Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, CA 94158, USA
Minshi Peng
5Department of Statistics and Data Science, Carnegie Mellon University, Pittsburgh, PA 15213, USA
Zhen Li
2Department of Neuroscience and Kavli Institute for Neuroscience, Yale School of Medicine, New Haven, CT 06510, USA
6Department of Neurosciences, University of California, San Diego, San Diego, CA 92093, USA
Claudia Dastmalchi
1Department of Psychiatry, UCSF Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, CA 94158, USA
Gabriel Santpere
2Department of Neuroscience and Kavli Institute for Neuroscience, Yale School of Medicine, New Haven, CT 06510, USA
Andre M. M. Sousa
2Department of Neuroscience and Kavli Institute for Neuroscience, Yale School of Medicine, New Haven, CT 06510, USA
Andrew T. N. Tebbenkamp
2Department of Neuroscience and Kavli Institute for Neuroscience, Yale School of Medicine, New Haven, CT 06510, USA
Navjot Kaur
2Department of Neuroscience and Kavli Institute for Neuroscience, Yale School of Medicine, New Haven, CT 06510, USA
Forrest O. Gulden
2Department of Neuroscience and Kavli Institute for Neuroscience, Yale School of Medicine, New Haven, CT 06510, USA
Michael S. Breen
7Seaver Autism Center for Research and Treatment, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA
8Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA
9Mindich Child Health and Development Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA
Lindsay Liang
1Department of Psychiatry, UCSF Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, CA 94158, USA
Michael C. Gilson
1Department of Psychiatry, UCSF Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, CA 94158, USA
Xuefang Zhao
10Center for Genomic Medicine and Department of Neurology, Massachusetts General Hospital, Boston, MA 02114, USA
11Department of Neurology, Harvard Medical School, Boston, MA 02115, USA
12Program in Medical and Population Genetics and Stanley Center for Psychiatric Research, Broad Institute, Cambridge, MA 02142, USA
Shan Dong
1Department of Psychiatry, UCSF Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, CA 94158, USA
Lambertus Klei
13Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
A. Ercument Cicek
14Department of Computer Engineering, Bilkent University, Ankara, 06800, Turkey
15Computational Biology Department, Carnegie Mellon University, Pittsburgh, PA 15213, USA
Joseph D. Buxbaum
7Seaver Autism Center for Research and Treatment, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA
8Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA
9Mindich Child Health and Development Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA
16Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA
Homa Adle-Biassette
17Department of Pathology, Lariboisière Hospital, APHP and Paris Diderot University, Sorbonne Paris Cité, Paris, France
Jean-Leon Thomas
18Department of Neurology, Yale University School of Medicine, New Haven, CT 06511, USA
19UMRS1127, Sorbonne Université, Institut du Cerveau et de la Moelle épinière, 7, Boulevard de l’Hôpital, 75013 Paris, France
Kimberly A. Aldinger
20Center for Integrative Brain Research, Seattle Children’s Research Institute, Seattle, WA 98101, USA
Diana R. O’Day
21Department of Pediatrics, the University of Washington, Seattle, WA 98105, USA
Ian A. Glass
21Department of Pediatrics, the University of Washington, Seattle, WA 98105, USA
Noah A. Zaitlen
22Department of Medicine, University of California, San Francisco, San Francisco, CA 94158, USA
Michael E. Talkowski
10Center for Genomic Medicine and Department of Neurology, Massachusetts General Hospital, Boston, MA 02114, USA
11Department of Neurology, Harvard Medical School, Boston, MA 02115, USA
12Program in Medical and Population Genetics and Stanley Center for Psychiatric Research, Broad Institute, Cambridge, MA 02142, USA
23Departments of Pathology and Psychiatry, Massachusetts General Hospital, Boston, MA 02114, USA
Kathryn Roeder
5Department of Statistics and Data Science, Carnegie Mellon University, Pittsburgh, PA 15213, USA
15Computational Biology Department, Carnegie Mellon University, Pittsburgh, PA 15213, USA
Matthew W. State
1Department of Psychiatry, UCSF Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, CA 94158, USA
24Institute for Human Genetics, University of California San Francisco, San Francisco, CA 94158, USA
Bernie Devlin
13Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
Stephan J. Sanders
1Department of Psychiatry, UCSF Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, CA 94158, USA
24Institute for Human Genetics, University of California San Francisco, San Francisco, CA 94158, USA
Nenad Sestan
2Department of Neuroscience and Kavli Institute for Neuroscience, Yale School of Medicine, New Haven, CT 06510, USA
25Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06520, USA
26Department of Genetics, Yale University School of Medicine, New Haven, CT 06520, USA
27Department of Comparative Medicine, Program in Integrative Cell Signaling and Neurobiology of Metabolism, Yale School of Medicine, New Haven, CT 06510, USA
28Program in Cellular Neuroscience, Neurodegeneration, and Repair and Yale Child Study Center, Yale School of Medicine, New Haven, CT 06510, USA
Article usage
Posted March 22, 2019.
Whole-genome and RNA sequencing reveal variation and transcriptomic coordination in the developing human prefrontal cortex
Donna M. Werling, Sirisha Pochareddy, Jinmyung Choi, Joon-Yong An, Brooke Sheppard, Minshi Peng, Zhen Li, Claudia Dastmalchi, Gabriel Santpere, Andre M. M. Sousa, Andrew T. N. Tebbenkamp, Navjot Kaur, Forrest O. Gulden, Michael S. Breen, Lindsay Liang, Michael C. Gilson, Xuefang Zhao, Shan Dong, Lambertus Klei, A. Ercument Cicek, Joseph D. Buxbaum, Homa Adle-Biassette, Jean-Leon Thomas, Kimberly A. Aldinger, Diana R. O’Day, Ian A. Glass, Noah A. Zaitlen, Michael E. Talkowski, Kathryn Roeder, Matthew W. State, Bernie Devlin, Stephan J. Sanders, Nenad Sestan
bioRxiv 585430; doi: https://doi.org/10.1101/585430
Whole-genome and RNA sequencing reveal variation and transcriptomic coordination in the developing human prefrontal cortex
Donna M. Werling, Sirisha Pochareddy, Jinmyung Choi, Joon-Yong An, Brooke Sheppard, Minshi Peng, Zhen Li, Claudia Dastmalchi, Gabriel Santpere, Andre M. M. Sousa, Andrew T. N. Tebbenkamp, Navjot Kaur, Forrest O. Gulden, Michael S. Breen, Lindsay Liang, Michael C. Gilson, Xuefang Zhao, Shan Dong, Lambertus Klei, A. Ercument Cicek, Joseph D. Buxbaum, Homa Adle-Biassette, Jean-Leon Thomas, Kimberly A. Aldinger, Diana R. O’Day, Ian A. Glass, Noah A. Zaitlen, Michael E. Talkowski, Kathryn Roeder, Matthew W. State, Bernie Devlin, Stephan J. Sanders, Nenad Sestan
bioRxiv 585430; doi: https://doi.org/10.1101/585430
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