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Epigenomic Landscape of Arabidopsis thaliana Metabolism Reveals Bivalent Chromatin on Specialized Metabolic Genes

View ORCID ProfileKangmei Zhao, Seung Y. Rhee
doi: https://doi.org/10.1101/589036
Kangmei Zhao
Carnegie Institution for Science, Department of Plant Biology, Stanford, CA, 94305
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Seung Y. Rhee
Carnegie Institution for Science, Department of Plant Biology, Stanford, CA, 94305
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  • For correspondence: srhee@carnegiescience.edu
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Abstract

Metabolism underpins development and physiology, but little is known about how metabolic genes and pathways are regulated, especially in multicellular organisms. Here, we identified regulatory patterns of 16 epigenetic modifications across metabolism in Arabidopsis thaliana. Surprisingly, specialized metabolic genes, often involved in defense, were predominantly regulated by two modifications that have opposite effects on gene expression, H3K27me3 (repression) and H3K18ac (activation). Using camalexin biosynthesis genes as an example, we confirmed that these two modifications were co-localized to form bivalent chromatin. Mutants defective in H3K27m3 and H3K18ac modifications showed that both modifications are required to determine the normal transcriptional kinetics of these genes upon stress stimuli. Our study suggests that this type of bivalent chromatin, which we name a kairostat, controls the precise timing of gene expression upon stimuli.

One Sentence Summary This study identified a novel regulatory mechanism controlling specialized metabolism in Arabidopsis thaliana.

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Posted March 26, 2019.
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Epigenomic Landscape of Arabidopsis thaliana Metabolism Reveals Bivalent Chromatin on Specialized Metabolic Genes
Kangmei Zhao, Seung Y. Rhee
bioRxiv 589036; doi: https://doi.org/10.1101/589036
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Epigenomic Landscape of Arabidopsis thaliana Metabolism Reveals Bivalent Chromatin on Specialized Metabolic Genes
Kangmei Zhao, Seung Y. Rhee
bioRxiv 589036; doi: https://doi.org/10.1101/589036

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