Skip to main content
bioRxiv
  • Home
  • About
  • Submit
  • ALERTS / RSS
Advanced Search
New Results

MiR-218: A Molecular Switch and Potential Biomarker of Susceptibility to Stress

Angélica Torres-Berrío, Dominique Nouel, Santiago Cuesta, Eric M. Parise, José María Restrepo-Lozano, Pier Larochelle, Eric J. Nestler, Cecilia Flores
doi: https://doi.org/10.1101/589325
Angélica Torres-Berrío
Integrated Program in Neuroscience, McGill University, Montréal, Québec, CanadaDouglas Mental Health University Institute, Montréal, Québec, CanadaDepartment of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY USA
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Dominique Nouel
Douglas Mental Health University Institute, Montréal, Québec, Canada
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Santiago Cuesta
Douglas Mental Health University Institute, Montréal, Québec, CanadaDepartment of Psychiatry, McGill University, Montréal, Québec, Canada
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Eric M. Parise
Department of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY USA
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
José María Restrepo-Lozano
Integrated Program in Neuroscience, McGill University, Montréal, Québec, CanadaDouglas Mental Health University Institute, Montréal, Québec, Canada
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Pier Larochelle
Douglas Mental Health University Institute, Montréal, Québec, Canada
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Eric J. Nestler
Department of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY USA
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Cecilia Flores
Douglas Mental Health University Institute, Montréal, Québec, CanadaDepartment of Psychiatry, McGill University, Montréal, Québec, Canada
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • For correspondence: cecilia.flores@mcgill.ca
  • Abstract
  • Full Text
  • Info/History
  • Metrics
  • Supplementary material
  • Preview PDF
Loading

ABSTRACT

Low miR-218 expression in the medial prefrontal cortex (mPFC) is a consistent trait of depression. Here we assessed whether miR-218 in the mPFC confers resilience or susceptibility to depression-like behaviors in adult mice, using the chronic social defeat stress (CSDS) model of depression. We also investigated whether stress-induced variations of miR-218 expression in the mPFC can be detected in blood. We find that downregulation of miR-218 in the mPFC increases susceptibility to a single session of social defeat, whereas overexpression of miR-218 selectively in mPFC pyramidal neurons promotes resilience to CSDS and prevents stress-induced morphological alterations to those neurons. After CSDS, susceptible mice have low levels of miR-218 in the blood as compared to control or resilient groups. We show further that up-and downregulation of miR-218 levels specifically in the mPFC correlates with miR-218 expression in blood. Our results suggest that miR-218 in the adult mPFC might function as a molecular switch that determines susceptibility versus resilience to chronic stress, and that stress-induced variations in mPFC levels of miR-218 could be detected in blood. We propose that blood expression of miR-218 might serve as potential readout of vulnerability to stress and as a proxy of mPFC function.

Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. All rights reserved. No reuse allowed without permission.
Back to top
PreviousNext
Posted March 28, 2019.
Download PDF

Supplementary Material

Email

Thank you for your interest in spreading the word about bioRxiv.

NOTE: Your email address is requested solely to identify you as the sender of this article.

Enter multiple addresses on separate lines or separate them with commas.
MiR-218: A Molecular Switch and Potential Biomarker of Susceptibility to Stress
(Your Name) has forwarded a page to you from bioRxiv
(Your Name) thought you would like to see this page from the bioRxiv website.
Share
MiR-218: A Molecular Switch and Potential Biomarker of Susceptibility to Stress
Angélica Torres-Berrío, Dominique Nouel, Santiago Cuesta, Eric M. Parise, José María Restrepo-Lozano, Pier Larochelle, Eric J. Nestler, Cecilia Flores
bioRxiv 589325; doi: https://doi.org/10.1101/589325
Digg logo Reddit logo Twitter logo CiteULike logo Facebook logo Google logo Mendeley logo
Citation Tools
MiR-218: A Molecular Switch and Potential Biomarker of Susceptibility to Stress
Angélica Torres-Berrío, Dominique Nouel, Santiago Cuesta, Eric M. Parise, José María Restrepo-Lozano, Pier Larochelle, Eric J. Nestler, Cecilia Flores
bioRxiv 589325; doi: https://doi.org/10.1101/589325

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
  • Tweet Widget
  • Facebook Like
  • Google Plus One

Subject Area

  • Neuroscience
Subject Areas
All Articles
  • Animal Behavior and Cognition (1641)
  • Biochemistry (2721)
  • Bioengineering (1902)
  • Bioinformatics (10202)
  • Biophysics (4174)
  • Cancer Biology (3202)
  • Cell Biology (4522)
  • Clinical Trials (135)
  • Developmental Biology (2831)
  • Ecology (4447)
  • Epidemiology (2041)
  • Evolutionary Biology (7213)
  • Genetics (5464)
  • Genomics (6795)
  • Immunology (2379)
  • Microbiology (7462)
  • Molecular Biology (2978)
  • Neuroscience (18529)
  • Paleontology (135)
  • Pathology (472)
  • Pharmacology and Toxicology (776)
  • Physiology (1147)
  • Plant Biology (2692)
  • Scientific Communication and Education (679)
  • Synthetic Biology (885)
  • Systems Biology (2840)
  • Zoology (465)