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Childhood socio-economic disadvantage predicts reduced myelin growth across adolescence and young adulthood

Gabriel Ziegler, View ORCID ProfileMichael Moutoussis, Tobias U. Hauser, Pasco Fearon, Edward T. Bullmore, Ian M. Goodyer, Peter Fonagy, Peter B. Jones, NSPN Consortium, Ulman Lindenberger, Raymond J. Dolan
doi: https://doi.org/10.1101/589713
Gabriel Ziegler
Max Planck University College London Centre for Computational Psychiatry and Ageing Research, London WC1B 5EH, United Kingdom and 14195 Berlin, GermanyWellcome Centre for Human Neuroimaging, University College London, London WC1N 3BG, United KingdomInstitute of Cognitive Neurology and Dementia Research, Otto-von-Guericke-University Magdeburg, 39120 Magdeburg, GermanyGerman Center for Neurodegenerative Diseases (DZNE), 39120 Magdeburg, Germany
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Michael Moutoussis
Max Planck University College London Centre for Computational Psychiatry and Ageing Research, London WC1B 5EH, United Kingdom and 14195 Berlin, GermanyWellcome Centre for Human Neuroimaging, University College London, London WC1N 3BG, United Kingdom
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  • ORCID record for Michael Moutoussis
  • For correspondence: m.moutoussis@ucl.ac.uk
Tobias U. Hauser
Max Planck University College London Centre for Computational Psychiatry and Ageing Research, London WC1B 5EH, United Kingdom and 14195 Berlin, GermanyWellcome Centre for Human Neuroimaging, University College London, London WC1N 3BG, United Kingdom
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Pasco Fearon
Research Department of Clinical, Educational and Health Psychology, University College London, London WC1E 6BT, United Kingdom
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Edward T. Bullmore
Department of Psychiatry, University of Cambridge, Cambridge CB2 0SZ, United KingdomCambridgeshire and Peterborough National Health Service Foundation Trust, Cambridge, CB21 5EF, United KingdomMedical Research Council/Wellcome Trust Behavioural and Clinical Neuroscience Institute, University of Cambridge, Cambridge CB2 3EB, United KingdomImmunoPsychiatry, GlaxoSmithKline Research and Development, Stevenage SG1 2NY, United Kingdom
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Ian M. Goodyer
Department of Psychiatry, University of Cambridge, Cambridge CB2 0SZ, United KingdomCambridgeshire and Peterborough National Health Service Foundation Trust, Cambridge, CB21 5EF, United Kingdom
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Peter Fonagy
Research Department of Clinical, Educational and Health Psychology, University College London, London WC1E 6BT, United Kingdom
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Peter B. Jones
Department of Psychiatry, University of Cambridge, Cambridge CB2 0SZ, United KingdomCambridgeshire and Peterborough National Health Service Foundation Trust, Cambridge, CB21 5EF, United Kingdom
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Ulman Lindenberger
Max Planck University College London Centre for Computational Psychiatry and Ageing Research, London WC1B 5EH, United Kingdom and 14195 Berlin, GermanyCenter for Lifespan Psychology, Max Planck Institute for Human Development, Berlin, Germany
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Raymond J. Dolan
Max Planck University College London Centre for Computational Psychiatry and Ageing Research, London WC1B 5EH, United Kingdom and 14195 Berlin, GermanyWellcome Centre for Human Neuroimaging, University College London, London WC1N 3BG, United Kingdom
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Abstract

Socio-economic disadvantage (SED) increases exposure to life stressors. Animal research suggests early life stressors affect later neurodevelopment, including myelin developmental growth. To determine whether human childhood SED affects myelination in adolescence and early adulthood we measured the developmental increase of a sensitive myelin marker, magnetization transfer (MT), in a longitudinal study. Childhood SED was associated with globally reduced MT, as well as slower intra-cortical MT increase in widespread sensory-motor, cingulate, insular and prefrontal areas and subcortical areas. Parental education partially accounted for the SED effects on MT increase, while positive parenting provided a partial protection against the impact of SED. Thus, early socio-economic disadvantage, a vulnerability factor for a range of ill-health outcomes, is a risk factor for aberrant myelin growth during a critical developmental period that is associated with a high risk of psychiatric disorder.

Footnotes

  • ↵10 The list of the NSPN Consortium members can be found in the supplementary table 6

  • ↵* Joint first authors

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The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC-ND 4.0 International license.
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Posted March 28, 2019.
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Childhood socio-economic disadvantage predicts reduced myelin growth across adolescence and young adulthood
Gabriel Ziegler, Michael Moutoussis, Tobias U. Hauser, Pasco Fearon, Edward T. Bullmore, Ian M. Goodyer, Peter Fonagy, Peter B. Jones, NSPN Consortium, Ulman Lindenberger, Raymond J. Dolan
bioRxiv 589713; doi: https://doi.org/10.1101/589713
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Childhood socio-economic disadvantage predicts reduced myelin growth across adolescence and young adulthood
Gabriel Ziegler, Michael Moutoussis, Tobias U. Hauser, Pasco Fearon, Edward T. Bullmore, Ian M. Goodyer, Peter Fonagy, Peter B. Jones, NSPN Consortium, Ulman Lindenberger, Raymond J. Dolan
bioRxiv 589713; doi: https://doi.org/10.1101/589713

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