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A Synergistic Anti-Cancer FAK and HDAC Inhibitor Combination Discovered by a Novel Chemical-Genetic High-Content Phenotypic Screen

John C. Dawson, View ORCID ProfileBryan Serrels, Adam Byron, Morwenna Muir, Ashraff Makda, Amaya García-Muñoz, Alex von Kriegsheim, Neil O. Carragher, View ORCID ProfileMargaret C. Frame
doi: https://doi.org/10.1101/590802
John C. Dawson
1Cancer Research UK Edinburgh Centre, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, United Kingdom
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Bryan Serrels
1Cancer Research UK Edinburgh Centre, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, United Kingdom
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Adam Byron
1Cancer Research UK Edinburgh Centre, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, United Kingdom
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Morwenna Muir
1Cancer Research UK Edinburgh Centre, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, United Kingdom
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Ashraff Makda
1Cancer Research UK Edinburgh Centre, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, United Kingdom
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Amaya García-Muñoz
2Systems Biology Ireland, University College Dublin, Dublin, Ireland
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Alex von Kriegsheim
1Cancer Research UK Edinburgh Centre, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, United Kingdom
2Systems Biology Ireland, University College Dublin, Dublin, Ireland
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Neil O. Carragher
1Cancer Research UK Edinburgh Centre, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, United Kingdom
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  • For correspondence: m.frame@ed.ac.uk n.carragher@ed.ac.uk
Margaret C. Frame
1Cancer Research UK Edinburgh Centre, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, United Kingdom
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  • ORCID record for Margaret C. Frame
  • For correspondence: m.frame@ed.ac.uk n.carragher@ed.ac.uk
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Posted March 27, 2019.
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A Synergistic Anti-Cancer FAK and HDAC Inhibitor Combination Discovered by a Novel Chemical-Genetic High-Content Phenotypic Screen
John C. Dawson, Bryan Serrels, Adam Byron, Morwenna Muir, Ashraff Makda, Amaya García-Muñoz, Alex von Kriegsheim, Neil O. Carragher, Margaret C. Frame
bioRxiv 590802; doi: https://doi.org/10.1101/590802
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A Synergistic Anti-Cancer FAK and HDAC Inhibitor Combination Discovered by a Novel Chemical-Genetic High-Content Phenotypic Screen
John C. Dawson, Bryan Serrels, Adam Byron, Morwenna Muir, Ashraff Makda, Amaya García-Muñoz, Alex von Kriegsheim, Neil O. Carragher, Margaret C. Frame
bioRxiv 590802; doi: https://doi.org/10.1101/590802

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