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During hippocampal inactivation, grid cells maintain their synchrony, even when the grid pattern is lost

Noam Almog, Gilad Tocker, Tora Bonnevie, Edvard Moser, May-Britt Moser, View ORCID ProfileDori Derdikman
doi: https://doi.org/10.1101/592006
Noam Almog
1Rappaport Faculty of Medicine and Research Institute, Technion – Israel Institute of Technology
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Gilad Tocker
1Rappaport Faculty of Medicine and Research Institute, Technion – Israel Institute of Technology
2Gonda Multidisciplinary Brain Research Center, Bar Ilan University
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Tora Bonnevie
3Kavli Institute for Systems Neuroscience and Centre for Neural Computation, Norwegian University of Science and Technology
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Edvard Moser
3Kavli Institute for Systems Neuroscience and Centre for Neural Computation, Norwegian University of Science and Technology
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May-Britt Moser
3Kavli Institute for Systems Neuroscience and Centre for Neural Computation, Norwegian University of Science and Technology
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Dori Derdikman
1Rappaport Faculty of Medicine and Research Institute, Technion – Israel Institute of Technology
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  • ORCID record for Dori Derdikman
  • For correspondence: derdik@technion.ac.il
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Abstract

The grid cell network in the MEC has been subject to thorough testing and analysis, and many theories for their formation have been suggested. To test some of these theories we re-analyzed data from Bonnevie et al. (2013), in which the hippocampus was inactivated and grid cells were recorded in the MEC, to investigate whether the firing associations of grid cells depend on hippocampal inputs. Specifically, we examined temporal and spatial correlations in the firing times of simultaneously recorded grid cells before and during hippocampal inactivation. Our analysis revealed evidence of network coherence in grid cells even in the absence of hippocampal input to the MEC, both in regular grid cells and in those that became head-direction cells after hippocampal inactivation. This favors models which suggest that phase relations between grid cells in the MEC are dependent on intrinsic connectivity within the MEC.

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The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY 4.0 International license.
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Posted August 27, 2019.
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During hippocampal inactivation, grid cells maintain their synchrony, even when the grid pattern is lost
Noam Almog, Gilad Tocker, Tora Bonnevie, Edvard Moser, May-Britt Moser, Dori Derdikman
bioRxiv 592006; doi: https://doi.org/10.1101/592006
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During hippocampal inactivation, grid cells maintain their synchrony, even when the grid pattern is lost
Noam Almog, Gilad Tocker, Tora Bonnevie, Edvard Moser, May-Britt Moser, Dori Derdikman
bioRxiv 592006; doi: https://doi.org/10.1101/592006

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