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A fast and efficient colocalization algorithm for identifying shared genetic risk factors across multiple traits

Christopher N Foley, James R Staley, Philip G Breen, Benjamin B Sun, Paul D W Kirk, Stephen Burgess, Joanna M M Howson
doi: https://doi.org/10.1101/592238
Christopher N Foley
1MRC Biostatistics Unit, Cambridge Institute of Public Health, University of Cambridge, Cambridge, CB2 0SR, UK
2Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, CB1 8RN, UK
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  • For correspondence: christopher.foley@mrc-bsu.cam.ac.uk
James R Staley
2Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, CB1 8RN, UK
3MRC Integrative Epidemiology Unit, Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, BS8 2BN, UK
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Philip G Breen
4School of Mathematics and Maxwell Institute for Mathematical Sciences, University of Edinburgh, Kings Buildings, Edinburgh, EH9 3JZ
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Benjamin B Sun
2Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, CB1 8RN, UK
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Paul D W Kirk
1MRC Biostatistics Unit, Cambridge Institute of Public Health, University of Cambridge, Cambridge, CB2 0SR, UK
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Stephen Burgess
1MRC Biostatistics Unit, Cambridge Institute of Public Health, University of Cambridge, Cambridge, CB2 0SR, UK
2Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, CB1 8RN, UK
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Joanna M M Howson
2Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, CB1 8RN, UK
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Article Information

doi 
https://doi.org/10.1101/592238
History 
  • March 28, 2019.
Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-ND 4.0 International license.

Author Information

  1. Christopher N Foley*,1,2,
  2. James R Staley2,3,
  3. Philip G Breen4,
  4. Benjamin B Sun2,
  5. Paul D W Kirk1,
  6. Stephen Burgess1,2 and
  7. Joanna M M Howson2
  1. 1MRC Biostatistics Unit, Cambridge Institute of Public Health, University of Cambridge, Cambridge, CB2 0SR, UK
  2. 2Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, CB1 8RN, UK
  3. 3MRC Integrative Epidemiology Unit, Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, BS8 2BN, UK
  4. 4School of Mathematics and Maxwell Institute for Mathematical Sciences, University of Edinburgh, Kings Buildings, Edinburgh, EH9 3JZ
  1. ↵*Correspondence: Dr Christopher N Foley, MRC Biostatistics Unit, Cambridge Institute of Public Health, University of Cambridge, Cambridge, CB2 0SR, UK. Email: christopher.foley{at}mrc-bsu.cam.ac.uk, Telephone: +44 (0)1223 748671, Fax: +44 (0)1223 330365
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Posted March 28, 2019.
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A fast and efficient colocalization algorithm for identifying shared genetic risk factors across multiple traits
Christopher N Foley, James R Staley, Philip G Breen, Benjamin B Sun, Paul D W Kirk, Stephen Burgess, Joanna M M Howson
bioRxiv 592238; doi: https://doi.org/10.1101/592238
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A fast and efficient colocalization algorithm for identifying shared genetic risk factors across multiple traits
Christopher N Foley, James R Staley, Philip G Breen, Benjamin B Sun, Paul D W Kirk, Stephen Burgess, Joanna M M Howson
bioRxiv 592238; doi: https://doi.org/10.1101/592238

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