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A single-nuclei RNA sequencing study of Mendelian and sporadic AD in the human brain

Jorge L. Del-Aguila, Zeran Li, Umber Dube, Kathie A. Mihindukulasuriya, John P Budde, Maria Victoria Fernandez, Laura Ibanez, Joseph Bradley, Fengxian Wang, Kristy Bergmann, Richard Davenport, John C. Morris, David M. Holtzman, Richard J. Perrin, Bruno A. Benitez, View ORCID ProfileJoseph Dougherty, Carlos Cruchaga, Oscar Harari
doi: https://doi.org/10.1101/593756
Jorge L. Del-Aguila
Department of Psychiatry, Washington University School of Medicine, St. Louis, MO, USAHope Center for Neurological Disorders, Washington University School of Medicine, St. Louis, MO, USANeuroGenomics and Informatics, Department of Psychiatry Washington University in St. Louis
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Zeran Li
Department of Psychiatry, Washington University School of Medicine, St. Louis, MO, USAHope Center for Neurological Disorders, Washington University School of Medicine, St. Louis, MO, USANeuroGenomics and Informatics, Department of Psychiatry Washington University in St. Louis
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Umber Dube
Department of Psychiatry, Washington University School of Medicine, St. Louis, MO, USAHope Center for Neurological Disorders, Washington University School of Medicine, St. Louis, MO, USANeuroGenomics and Informatics, Department of Psychiatry Washington University in St. Louis
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Kathie A. Mihindukulasuriya
Department of Psychiatry, Washington University School of Medicine, St. Louis, MO, USANeuroGenomics and Informatics, Department of Psychiatry Washington University in St. Louis
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John P Budde
Department of Psychiatry, Washington University School of Medicine, St. Louis, MO, USAHope Center for Neurological Disorders, Washington University School of Medicine, St. Louis, MO, USANeuroGenomics and Informatics, Department of Psychiatry Washington University in St. Louis
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Maria Victoria Fernandez
Department of Psychiatry, Washington University School of Medicine, St. Louis, MO, USAHope Center for Neurological Disorders, Washington University School of Medicine, St. Louis, MO, USANeuroGenomics and Informatics, Department of Psychiatry Washington University in St. Louis
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Laura Ibanez
Department of Psychiatry, Washington University School of Medicine, St. Louis, MO, USAHope Center for Neurological Disorders, Washington University School of Medicine, St. Louis, MO, USANeuroGenomics and Informatics, Department of Psychiatry Washington University in St. Louis
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Joseph Bradley
Department of Psychiatry, Washington University School of Medicine, St. Louis, MO, USAHope Center for Neurological Disorders, Washington University School of Medicine, St. Louis, MO, USANeuroGenomics and Informatics, Department of Psychiatry Washington University in St. Louis
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Fengxian Wang
Department of Psychiatry, Washington University School of Medicine, St. Louis, MO, USAHope Center for Neurological Disorders, Washington University School of Medicine, St. Louis, MO, USANeuroGenomics and Informatics, Department of Psychiatry Washington University in St. Louis
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Kristy Bergmann
Department of Psychiatry, Washington University School of Medicine, St. Louis, MO, USAHope Center for Neurological Disorders, Washington University School of Medicine, St. Louis, MO, USA
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Richard Davenport
Department of Psychiatry, Washington University School of Medicine, St. Louis, MO, USAHope Center for Neurological Disorders, Washington University School of Medicine, St. Louis, MO, USA
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John C. Morris
Hope Center for Neurological Disorders, Washington University School of Medicine, St. Louis, MO, USAKnight Alzheimer’s Disease Research Center, Washington University School of Medicine, St. Louis, MO, USADepartment of Neurology, Washington University School of Medicine, St. Louis, MO, USA
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David M. Holtzman
Hope Center for Neurological Disorders, Washington University School of Medicine, St. Louis, MO, USAKnight Alzheimer’s Disease Research Center, Washington University School of Medicine, St. Louis, MO, USADepartment of Neurology, Washington University School of Medicine, St. Louis, MO, USA
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Richard J. Perrin
Hope Center for Neurological Disorders, Washington University School of Medicine, St. Louis, MO, USAKnight Alzheimer’s Disease Research Center, Washington University School of Medicine, St. Louis, MO, USADepartment of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO, USA
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Bruno A. Benitez
Department of Psychiatry, Washington University School of Medicine, St. Louis, MO, USANeuroGenomics and Informatics, Department of Psychiatry Washington University in St. Louis
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Joseph Dougherty
Department of Genetics, Washington University School of Medicine, St. Louis, MO, USA
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  • ORCID record for Joseph Dougherty
Carlos Cruchaga
Department of Psychiatry, Washington University School of Medicine, St. Louis, MO, USAHope Center for Neurological Disorders, Washington University School of Medicine, St. Louis, MO, USAKnight Alzheimer’s Disease Research Center, Washington University School of Medicine, St. Louis, MO, USANeuroGenomics and Informatics, Department of Psychiatry Washington University in St. Louis
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  • For correspondence: cruchagac@wustl.edu harario@wustl.edu
Oscar Harari
Department of Psychiatry, Washington University School of Medicine, St. Louis, MO, USAHope Center for Neurological Disorders, Washington University School of Medicine, St. Louis, MO, USAKnight Alzheimer’s Disease Research Center, Washington University School of Medicine, St. Louis, MO, USANeuroGenomics and Informatics, Department of Psychiatry Washington University in St. Louis
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  • For correspondence: cruchagac@wustl.edu harario@wustl.edu
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Article Information

doi 
https://doi.org/10.1101/593756
History 
  • April 18, 2019.

Article Versions

  • older version (March 30, 2019 - 05:40).
  • You are viewing the most recent version of this article.
Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. All rights reserved. No reuse allowed without permission.

Author Information

  1. Jorge L. Del-Aguilaa,b,d,
  2. Zeran Lia,b,d,
  3. Umber Dubea,b,d,
  4. Kathie A. Mihindukulasuriyaa,d,
  5. John P Buddea,b,d,
  6. Maria Victoria Fernandeza,b,d,
  7. Laura Ibaneza,b,d,
  8. Joseph Bradleya,b,d,
  9. Fengxian Wanga,b,d,
  10. Kristy Bergmanna,b,
  11. Richard Davenporta,b,
  12. John C. Morrisb,c,e,
  13. David M. Holtzmanb,c,e,
  14. Richard J. Perrinb,c,f,
  15. Bruno A. Beniteza,d,
  16. Joseph Doughertyg,
  17. Carlos Cruchagaa,b,c,d,* and
  18. Oscar Hararia,b,c,d,*
  1. aDepartment of Psychiatry, Washington University School of Medicine, St. Louis, MO, USA
  2. bHope Center for Neurological Disorders, Washington University School of Medicine, St. Louis, MO, USA
  3. cKnight Alzheimer’s Disease Research Center, Washington University School of Medicine, St. Louis, MO, USA
  4. dNeuroGenomics and Informatics, Department of Psychiatry Washington University in St. Louis
  5. eDepartment of Neurology, Washington University School of Medicine, St. Louis, MO, USA
  6. fDepartment of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO, USA
  7. gDepartment of Genetics, Washington University School of Medicine, St. Louis, MO, USA
  1. ↵*To whom correspondence should be addressed: Carlos Cruchaga, PhD, Professor Dep. of Psychiatry, Genetics and Neurology, Washington University School of Medicine, Campus Box 8134 | 425 S. Euclid Ave |BJC Institute of Health |Office: 9607 | St. Louis, MO, 63110, Tel: (314) 286-0546 | Fax: (314) 362-2244, Email: cruchagac{at}wustl.edu, Oscar Harari, PhD, Assistant Professor, Department of Psychiatry, Washington University School of Medicine, Campus Box 8134 | 425 S. Euclid Ave |BJC Institute of Health |Office: 9615 | St. Louis, MO, 63110, Tel: 314-273-1862 | Fax: 314-362-2244, Email: harario{at}wustl.edu
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A single-nuclei RNA sequencing study of Mendelian and sporadic AD in the human brain
Jorge L. Del-Aguila, Zeran Li, Umber Dube, Kathie A. Mihindukulasuriya, John P Budde, Maria Victoria Fernandez, Laura Ibanez, Joseph Bradley, Fengxian Wang, Kristy Bergmann, Richard Davenport, John C. Morris, David M. Holtzman, Richard J. Perrin, Bruno A. Benitez, Joseph Dougherty, Carlos Cruchaga, Oscar Harari
bioRxiv 593756; doi: https://doi.org/10.1101/593756
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A single-nuclei RNA sequencing study of Mendelian and sporadic AD in the human brain
Jorge L. Del-Aguila, Zeran Li, Umber Dube, Kathie A. Mihindukulasuriya, John P Budde, Maria Victoria Fernandez, Laura Ibanez, Joseph Bradley, Fengxian Wang, Kristy Bergmann, Richard Davenport, John C. Morris, David M. Holtzman, Richard J. Perrin, Bruno A. Benitez, Joseph Dougherty, Carlos Cruchaga, Oscar Harari
bioRxiv 593756; doi: https://doi.org/10.1101/593756

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