A single-nuclei RNA sequencing study of Mendelian and sporadic AD in the human brain

Jorge L. Del-Aguila; Zeran Li; Umber Dube; Kathie A. Mihindukulasuriya; John P Budde; Maria Victoria Fernandez; Laura Ibanez; Joseph Bradley; Fengxian Wang; Kristy Bergmann; Richard Davenport; John C. Morris; David M. Holtzman; Richard J. Perrin; Bruno A. Benitez; Joseph Dougherty; Carlos Cruchaga; Oscar Harari

doi:10.1101/593756

New Results

A single-nuclei RNA sequencing study of Mendelian and sporadic AD in the human brain

Jorge L. Del-Aguila, Zeran Li, Umber Dube, Kathie A. Mihindukulasuriya, John P Budde, Maria Victoria Fernandez, Laura Ibanez, Joseph Bradley, Fengxian Wang, Kristy Bergmann, Richard Davenport, John C. Morris, David M. Holtzman, Richard J. Perrin, Bruno A. Benitez, View ORCID ProfileJoseph Dougherty, Carlos Cruchaga, Oscar Harari

doi: https://doi.org/10.1101/593756

Jorge L. Del-Aguila

aDepartment of Psychiatry, Washington University School of Medicine, St. Louis, MO, USA

bHope Center for Neurological Disorders, Washington University School of Medicine, St. Louis, MO, USA

dNeuroGenomics and Informatics, Department of Psychiatry Washington University in St. Louis

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Zeran Li

aDepartment of Psychiatry, Washington University School of Medicine, St. Louis, MO, USA

bHope Center for Neurological Disorders, Washington University School of Medicine, St. Louis, MO, USA

dNeuroGenomics and Informatics, Department of Psychiatry Washington University in St. Louis

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Umber Dube

aDepartment of Psychiatry, Washington University School of Medicine, St. Louis, MO, USA

bHope Center for Neurological Disorders, Washington University School of Medicine, St. Louis, MO, USA

dNeuroGenomics and Informatics, Department of Psychiatry Washington University in St. Louis

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Kathie A. Mihindukulasuriya

aDepartment of Psychiatry, Washington University School of Medicine, St. Louis, MO, USA

dNeuroGenomics and Informatics, Department of Psychiatry Washington University in St. Louis

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

John P Budde

aDepartment of Psychiatry, Washington University School of Medicine, St. Louis, MO, USA

bHope Center for Neurological Disorders, Washington University School of Medicine, St. Louis, MO, USA

dNeuroGenomics and Informatics, Department of Psychiatry Washington University in St. Louis

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Maria Victoria Fernandez

aDepartment of Psychiatry, Washington University School of Medicine, St. Louis, MO, USA

bHope Center for Neurological Disorders, Washington University School of Medicine, St. Louis, MO, USA

dNeuroGenomics and Informatics, Department of Psychiatry Washington University in St. Louis

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Laura Ibanez

aDepartment of Psychiatry, Washington University School of Medicine, St. Louis, MO, USA

bHope Center for Neurological Disorders, Washington University School of Medicine, St. Louis, MO, USA

dNeuroGenomics and Informatics, Department of Psychiatry Washington University in St. Louis

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Joseph Bradley

aDepartment of Psychiatry, Washington University School of Medicine, St. Louis, MO, USA

bHope Center for Neurological Disorders, Washington University School of Medicine, St. Louis, MO, USA

dNeuroGenomics and Informatics, Department of Psychiatry Washington University in St. Louis

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Fengxian Wang

aDepartment of Psychiatry, Washington University School of Medicine, St. Louis, MO, USA

bHope Center for Neurological Disorders, Washington University School of Medicine, St. Louis, MO, USA

dNeuroGenomics and Informatics, Department of Psychiatry Washington University in St. Louis

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Kristy Bergmann

aDepartment of Psychiatry, Washington University School of Medicine, St. Louis, MO, USA

bHope Center for Neurological Disorders, Washington University School of Medicine, St. Louis, MO, USA

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Richard Davenport

aDepartment of Psychiatry, Washington University School of Medicine, St. Louis, MO, USA

bHope Center for Neurological Disorders, Washington University School of Medicine, St. Louis, MO, USA

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

John C. Morris

bHope Center for Neurological Disorders, Washington University School of Medicine, St. Louis, MO, USA

cKnight Alzheimer’s Disease Research Center, Washington University School of Medicine, St. Louis, MO, USA

eDepartment of Neurology, Washington University School of Medicine, St. Louis, MO, USA

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

David M. Holtzman

bHope Center for Neurological Disorders, Washington University School of Medicine, St. Louis, MO, USA

cKnight Alzheimer’s Disease Research Center, Washington University School of Medicine, St. Louis, MO, USA

eDepartment of Neurology, Washington University School of Medicine, St. Louis, MO, USA

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Richard J. Perrin

bHope Center for Neurological Disorders, Washington University School of Medicine, St. Louis, MO, USA

cKnight Alzheimer’s Disease Research Center, Washington University School of Medicine, St. Louis, MO, USA

fDepartment of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO, USA

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Bruno A. Benitez

aDepartment of Psychiatry, Washington University School of Medicine, St. Louis, MO, USA

dNeuroGenomics and Informatics, Department of Psychiatry Washington University in St. Louis

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Joseph Dougherty

gDepartment of Genetics, Washington University School of Medicine, St. Louis, MO, USA

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
ORCID record for Joseph Dougherty

Carlos Cruchaga

aDepartment of Psychiatry, Washington University School of Medicine, St. Louis, MO, USA

bHope Center for Neurological Disorders, Washington University School of Medicine, St. Louis, MO, USA

cKnight Alzheimer’s Disease Research Center, Washington University School of Medicine, St. Louis, MO, USA

dNeuroGenomics and Informatics, Department of Psychiatry Washington University in St. Louis

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
For correspondence: cruchagac@wustl.edu harario@wustl.edu

Oscar Harari

aDepartment of Psychiatry, Washington University School of Medicine, St. Louis, MO, USA

bHope Center for Neurological Disorders, Washington University School of Medicine, St. Louis, MO, USA

cKnight Alzheimer’s Disease Research Center, Washington University School of Medicine, St. Louis, MO, USA

dNeuroGenomics and Informatics, Department of Psychiatry Washington University in St. Louis

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
For correspondence: cruchagac@wustl.edu harario@wustl.edu

Abstract
Full Text
Info/History
Metrics
Supplementary material
Preview PDF

Article usage

Article usage: March 2019 to August 2020

	Abstract	Full	Pdf
Mar 2019	246	0	45
Apr 2019	872	83	317
May 2019	370	267	328
Jun 2019	329	344	206
Jul 2019	241	386	212
Aug 2019	204	252	140
Sep 2019	122	268	88
Oct 2019	138	227	74
Nov 2019	102	166	39
Dec 2019	80	129	34
Jan 2020	133	183	71
Feb 2020	121	190	48
Mar 2020	72	97	33
Apr 2020	58	74	22
May 2020	74	78	33
Jun 2020	57	90	35
Jul 2020	59	117	53
Aug 2020	23	47	8