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The origins of anterograde interference in visuomotor adaptation

View ORCID ProfileGonzalo Lerner, Scott Albert, Pedro A. Caffaro, Jorge I. Villalta, Florencia Jacobacci, Reza Shadmehr, Valeria Della-Maggiore
doi: https://doi.org/10.1101/593996
Gonzalo Lerner
1Universidad de Buenos Aires. Facultad de Medicina. Departamento de fisiología y biofísica. Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET). Instituto de Fisiología y Biofísica Houssay, Buenos Aires, Argentina
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  • ORCID record for Gonzalo Lerner
Scott Albert
2Department of Biomedical Engineering, Johns Hopkins School of Medicine, Baltimore, USA
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Pedro A. Caffaro
1Universidad de Buenos Aires. Facultad de Medicina. Departamento de fisiología y biofísica. Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET). Instituto de Fisiología y Biofísica Houssay, Buenos Aires, Argentina
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Jorge I. Villalta
1Universidad de Buenos Aires. Facultad de Medicina. Departamento de fisiología y biofísica. Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET). Instituto de Fisiología y Biofísica Houssay, Buenos Aires, Argentina
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Florencia Jacobacci
1Universidad de Buenos Aires. Facultad de Medicina. Departamento de fisiología y biofísica. Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET). Instituto de Fisiología y Biofísica Houssay, Buenos Aires, Argentina
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Reza Shadmehr
2Department of Biomedical Engineering, Johns Hopkins School of Medicine, Baltimore, USA
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Valeria Della-Maggiore
1Universidad de Buenos Aires. Facultad de Medicina. Departamento de fisiología y biofísica. Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET). Instituto de Fisiología y Biofísica Houssay, Buenos Aires, Argentina
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ABSTRACT

Anterograde interference refers to the negative impact of prior learning on the propensity for future learning. Previous work has shown that subsequent adaptation to two perturbations of opposing sign, A and B, impairs performance in B. Here, we aimed to unveil the mechanism at the basis of anterograde interference by tracking its impact as a function of time through a 24h period. We found that the memory of A biased performance in B for all time intervals. Conversely, learning from error was hindered up to 1h following acquisition of A, with release from interference occurring at 6h. These findings suggest that poor performance induced by prior learning is driven by two distinct mechanisms: a long-lasting bias that acts as a prior and hinders the initial level of performance, and a short-lasting learning impairment that originates from a reduction in error-sensitivity. Our work provides insight into the timeline of memory stabilization in visuomotor adaptation.

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The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC-ND 4.0 International license.
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Posted March 31, 2019.
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The origins of anterograde interference in visuomotor adaptation
Gonzalo Lerner, Scott Albert, Pedro A. Caffaro, Jorge I. Villalta, Florencia Jacobacci, Reza Shadmehr, Valeria Della-Maggiore
bioRxiv 593996; doi: https://doi.org/10.1101/593996
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The origins of anterograde interference in visuomotor adaptation
Gonzalo Lerner, Scott Albert, Pedro A. Caffaro, Jorge I. Villalta, Florencia Jacobacci, Reza Shadmehr, Valeria Della-Maggiore
bioRxiv 593996; doi: https://doi.org/10.1101/593996

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