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Resting Eyes Closed Beta-Phase High Gamma-Amplitude Coupling Deficits in Children with Attention Deficit Hyperactivity Disorder

David Ibanez-Soria, Eleni Kroupi, Andrés Rojas, Marta Castellano, Jacobo Picardo, Gloria García-Banda, Mateu Servera, Giulio Ruffini, Aureli Soria-Frisch
doi: https://doi.org/10.1101/598003
David Ibanez-Soria
1Starlab Barcelona S.L.
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  • For correspondence: david.ibanez@starlab.es
Eleni Kroupi
1Starlab Barcelona S.L.
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Andrés Rojas
1Starlab Barcelona S.L.
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Marta Castellano
1Starlab Barcelona S.L.
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Jacobo Picardo
2Universitat Illes Balears
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Gloria García-Banda
2Universitat Illes Balears
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Mateu Servera
2Universitat Illes Balears
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Giulio Ruffini
1Starlab Barcelona S.L.
3Neuroelectrics Corporation
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Aureli Soria-Frisch
1Starlab Barcelona S.L.
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Abstract

Objective Attention-deficit hyperactivity disorder (ADHD) is the neurobehavioral disorder with the largest prevalence rate in childhood. ADHD is generally assessed based on physical examination of the child and interviews, and therefore prone to subjectivity. This fact may lead to a high risk of mis- and over-diagnosis, a problem that can be addressed through the use of objective markers.

Methods Here we propose to use phase-amplitude coupling as a digital biomarker in ADHD. We investigated the hypothesis that coupling between the phase of slow brain rhythms and the amplitude of fast rhythms is altered in the ADHD population. We tested this hypothesis measuring phase-amplitude coupling (PAC) in the 4 to 200Hz range in electroencephalographic (EEG) signals recorded in the central-frontal area in children during eyes closed resting state.

Results Using automatic clustering, we observed statistically significant beta-gamma PAC deficits in the ADHD population in the frontal-left hemisphere.

Conclusions These findings suggests alterations in the beta-gamma coupling in the ADHD population. We discuss the hypothesis that these alterations may be indicators of working memory and attention deficits.

Significance The study of the coupling between the different brain rhythms can potentially contribute to the understanding and clinical diagnosis of ADHD.

Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC-ND 4.0 International license.
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Posted April 05, 2019.
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Resting Eyes Closed Beta-Phase High Gamma-Amplitude Coupling Deficits in Children with Attention Deficit Hyperactivity Disorder
David Ibanez-Soria, Eleni Kroupi, Andrés Rojas, Marta Castellano, Jacobo Picardo, Gloria García-Banda, Mateu Servera, Giulio Ruffini, Aureli Soria-Frisch
bioRxiv 598003; doi: https://doi.org/10.1101/598003
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Resting Eyes Closed Beta-Phase High Gamma-Amplitude Coupling Deficits in Children with Attention Deficit Hyperactivity Disorder
David Ibanez-Soria, Eleni Kroupi, Andrés Rojas, Marta Castellano, Jacobo Picardo, Gloria García-Banda, Mateu Servera, Giulio Ruffini, Aureli Soria-Frisch
bioRxiv 598003; doi: https://doi.org/10.1101/598003

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