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Gallery Game: Smartphone-based Assessment of Long-Term Memory in Adults at Risk of Alzheimer’s Disease

Claire Lancaster, Ivan Koychev, Jasmine Blane, Amy Chinner, Christopher Chatham, Kirsten Taylor, Chris Hinds
doi: https://doi.org/10.1101/599175
Claire Lancaster
1Big Data Institute, University of Oxford, Oxford, United Kingdom
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Ivan Koychev
2Department of Psychiatry, University of Oxford, Warneford Hospital, Oxford, United Kingdom
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Jasmine Blane
2Department of Psychiatry, University of Oxford, Warneford Hospital, Oxford, United Kingdom
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Amy Chinner
2Department of Psychiatry, University of Oxford, Warneford Hospital, Oxford, United Kingdom
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Christopher Chatham
4Roche Innovation Centre, F.Hoffmann-La Roche Ltd., Grenzacherstrasse 124, 4070 Basel, Switzerland
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Kirsten Taylor
4Roche Innovation Centre, F.Hoffmann-La Roche Ltd., Grenzacherstrasse 124, 4070 Basel, Switzerland
5Faculty of Psychology, University of Basel, Basel, Switzerland
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Chris Hinds
1Big Data Institute, University of Oxford, Oxford, United Kingdom
3Oxford Health NHS Foundation Trust, Oxford, United Kingdom
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Abstract

Gallery Game, deployed within the Mezurio smartphone app, targets the processes of episodic memory first vulnerable to neurofibrillary tau-related degeneration in Alzheimer’s Disease, prioritising both perirhinal and entorhinal cortex/hippocampal demands. Thirty-five healthy adults (aged 40-59 years), biased towards those at elevated familial risk of dementia, completed daily Gallery Game tasks for a month. Assessments consisted of cross-modal paired-associate learning, with subsequent tests of recognition and recall following delays ranging from one to 13 days. There was a non-linear decline in memory retention with increasing delays between learning and test, with significant forgetting first reported following delays of three and five days for paired-associate recall and recognition respectively, supporting the need for ecologically valid measures of longer-term memory. Gallery Game outcomes correlated as expected with established neuropsychological memory assessments, confirming the validity of this digital assessment of episodic memory. In addition, there was preliminary support for utilising the perirhinal-dependent pattern of semantic errors during object recognition as a marker of early impairment, justifying ongoing validation against traditional biomarkers of Alzheimer’s disease.

Footnotes

  • ivan.koychev{at}psych.ox.ac.uk, jasmine.blane{at}psych.ox.ac.uk, amy.chinner{at}psych.ox.ac.uk, christopher.chatham{at}roche.com, kirsten.taylor{at}roche.com, chris.hinds{at}bdi.ox.ac.uk

  • ↵* Joint first authors

Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. All rights reserved. No reuse allowed without permission.
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Posted April 04, 2019.
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Gallery Game: Smartphone-based Assessment of Long-Term Memory in Adults at Risk of Alzheimer’s Disease
Claire Lancaster, Ivan Koychev, Jasmine Blane, Amy Chinner, Christopher Chatham, Kirsten Taylor, Chris Hinds
bioRxiv 599175; doi: https://doi.org/10.1101/599175
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Gallery Game: Smartphone-based Assessment of Long-Term Memory in Adults at Risk of Alzheimer’s Disease
Claire Lancaster, Ivan Koychev, Jasmine Blane, Amy Chinner, Christopher Chatham, Kirsten Taylor, Chris Hinds
bioRxiv 599175; doi: https://doi.org/10.1101/599175

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