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Brain imaging correlates of general intelligence in UK Biobank

View ORCID ProfileSR Cox, SJ Ritchie, C Fawns-Ritchie, EM Tucker-Drob, IJ Deary
doi: https://doi.org/10.1101/599472
SR Cox
Centre for Cognitive Ageing and Cognitive Epidemiology, The University of Edinburgh, UKDepartment of Psychology, The University of Edinburgh, UKScottish Imaging Network, A Platform for Scientific Excellence (SINAPSE) Collaboration, Edinburgh, UK
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  • For correspondence: simon.cox@ed.ac.uk
SJ Ritchie
Social, Genetic and Developmental Psychiatry Centre, King’s College London, London, UK
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C Fawns-Ritchie
Centre for Cognitive Ageing and Cognitive Epidemiology, The University of Edinburgh, UKDepartment of Psychology, The University of Edinburgh, UK
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EM Tucker-Drob
Department of Psychology, University of Texas, Austin, Texas, USA
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IJ Deary
Centre for Cognitive Ageing and Cognitive Epidemiology, The University of Edinburgh, UKDepartment of Psychology, The University of Edinburgh, UK
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Abstract

The associations between indices of brain structure and measured intelligence are not clear. In part, this is because the evidence to date comes from mostly small and heterogenous studies. Here, we report brain structure-intelligence associations on a large sample from the UK Biobank study. The overall N = 29,004, with N = 18,363 participants providing both brain MRI and cognitive data, and a minimum N = 7318 providing the MRI data alongside a complete four-test battery. Participants’ age range was 44-81 years (M = 63.13, SD = 7.48). A general factor of intelligence (g) was extracted from four varied cognitive tests, accounting for one third of the variance in the cognitive test scores. The association between (age-and sex-corrected) total brain volume and a latent factor of general intelligence is r = 0.275, 95% C.I. = [0.252, 0.299]. A model that incorporated multiple global measures of grey and white matter macro-and microstructure accounted for more than double the g variance in older participants compared to those in middle-age (13.4% and 5.9%, respectively). There were no sex differences in the magnitude of associations between g and total brain volume or other global aspects of brain structure. The largest brain regional correlates of g were volumes of the insula, frontal, anterior/superior and medial temporal, posterior and paracingulate, lateral occipital cortices, thalamic volume, and the white matter microstructure of thalamic and association fibres, and of the forceps minor.

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Posted April 04, 2019.
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Brain imaging correlates of general intelligence in UK Biobank
SR Cox, SJ Ritchie, C Fawns-Ritchie, EM Tucker-Drob, IJ Deary
bioRxiv 599472; doi: https://doi.org/10.1101/599472
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Brain imaging correlates of general intelligence in UK Biobank
SR Cox, SJ Ritchie, C Fawns-Ritchie, EM Tucker-Drob, IJ Deary
bioRxiv 599472; doi: https://doi.org/10.1101/599472

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