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Dorsal-to-ventral neocortical expansion is physically primed by ventral streaming of early embryonic preplate neurons

Kanako Saito, Mayumi Okamoto, Yuto Watanabe, Namiko Noguchi, Arata Nagasaka, Yuta Nishina, Tomoyasu Shinoda, Akira Sakakibara, View ORCID ProfileTakaki Miyata
doi: https://doi.org/10.1101/601617
Kanako Saito
1Anatomy and Cell Biology, Nagoya University Graduate School of Medicine
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Mayumi Okamoto
1Anatomy and Cell Biology, Nagoya University Graduate School of Medicine
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Yuto Watanabe
1Anatomy and Cell Biology, Nagoya University Graduate School of Medicine
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Namiko Noguchi
1Anatomy and Cell Biology, Nagoya University Graduate School of Medicine
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Arata Nagasaka
1Anatomy and Cell Biology, Nagoya University Graduate School of Medicine
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Yuta Nishina
1Anatomy and Cell Biology, Nagoya University Graduate School of Medicine
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Tomoyasu Shinoda
1Anatomy and Cell Biology, Nagoya University Graduate School of Medicine
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Akira Sakakibara
1Anatomy and Cell Biology, Nagoya University Graduate School of Medicine
2College of Life and Health Sciences, Chubu University
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Takaki Miyata
1Anatomy and Cell Biology, Nagoya University Graduate School of Medicine
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  • ORCID record for Takaki Miyata
  • For correspondence: tmiyata@med.nagoya-u.ac.jp
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Summary

Mammalian neocortex exhibits a disproportionally “luxurious” representation of somatotopies in its lateral region, which depends on dorsal-to-ventral expansion of the pallium during development. Despite recent studies elucidating the molecular mechanisms underlying the cortical arealization/patterning, we know very little about how the cortex expands ventrally and the nature of the underlying force-generating events. We found that neurons born earliest (at embryonic day 10 [E10]) in the mouse pallium migrated ventrally and then extended corticofugal axons, which together formed a morphogenetic flow of the preplate that persists until E13. These neurons exerted pulling and pushing forces at the process and the soma, respectively. Ablation of these E10-born neurons attenuated both deflection of radial glial fibers (by E13) and extension of the cortical plate (by E14), which should occur ventrally, and subsequently shrank the postnatal neocortical map dorsally. This previously unrecognized preplate stream physically primes neocortical expansion and somatotopic map formation.

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The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC-ND 4.0 International license.
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Posted April 07, 2019.
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Dorsal-to-ventral neocortical expansion is physically primed by ventral streaming of early embryonic preplate neurons
Kanako Saito, Mayumi Okamoto, Yuto Watanabe, Namiko Noguchi, Arata Nagasaka, Yuta Nishina, Tomoyasu Shinoda, Akira Sakakibara, Takaki Miyata
bioRxiv 601617; doi: https://doi.org/10.1101/601617
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Dorsal-to-ventral neocortical expansion is physically primed by ventral streaming of early embryonic preplate neurons
Kanako Saito, Mayumi Okamoto, Yuto Watanabe, Namiko Noguchi, Arata Nagasaka, Yuta Nishina, Tomoyasu Shinoda, Akira Sakakibara, Takaki Miyata
bioRxiv 601617; doi: https://doi.org/10.1101/601617

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