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Within-family studies for Mendelian randomization: avoiding dynastic, assortative mating, and population stratification biases
View ORCID ProfileBen Brumpton, View ORCID ProfileEleanor Sanderson, View ORCID ProfileFernando Pires Hartwig, View ORCID ProfileSean Harrison, View ORCID ProfileGunnhild Åberge Vie, View ORCID ProfileYoonsu Cho, View ORCID ProfileLaura D Howe, View ORCID ProfileAmanda Hughes, View ORCID ProfileDorret I Boomsma, View ORCID ProfileAlexandra Havdahl, View ORCID ProfileJohn Hopper, View ORCID ProfileMichael Neale, View ORCID ProfileMichel G Nivard, View ORCID ProfileNancy L Pedersen, View ORCID ProfileChandra A Reynolds, Elliot M Tucker-Drob, View ORCID ProfileAndrew Grotzinger, View ORCID ProfileLaurence Howe, View ORCID ProfileTim Morris, View ORCID ProfileShuai Li, MR within-family Consortium, Wei-Min Chen, Johan Håkon Bjørngaard, View ORCID ProfileKristian Hveem, View ORCID ProfileCristen Willer, David M Evans, Jaakko Kaprio, Bjørn Olav Åsvol, George Davey Smith, Bjørn Olav Åsvold, View ORCID ProfileGibran Hemani, View ORCID ProfileNeil M Davies
doi: https://doi.org/10.1101/602516
Ben Brumpton
1K.G. Jebsen Center for Genetic Epidemiology, Department of Public Health and Nursing, NTNU, Norwegian University of Science and Technology, Norway
2Medical Research Council Integrative Epidemiology Unit, University of Bristol, BS8 2BN, United Kingdom
3Clinic of Thoracic and Occupational Medicine, St. Olavs Hospital, Trondheim University Hospital
Eleanor Sanderson
2Medical Research Council Integrative Epidemiology Unit, University of Bristol, BS8 2BN, United Kingdom
4Population Health Sciences, Bristol Medical School, University of Bristol, Barley House, Oakfield Grove, Bristol, BS8 2BN, United Kingdom
Fernando Pires Hartwig
2Medical Research Council Integrative Epidemiology Unit, University of Bristol, BS8 2BN, United Kingdom
5Postgraduate Program in Epidemiology, Federal University of Pelotas, Pelotas, Brazil
Sean Harrison
2Medical Research Council Integrative Epidemiology Unit, University of Bristol, BS8 2BN, United Kingdom
4Population Health Sciences, Bristol Medical School, University of Bristol, Barley House, Oakfield Grove, Bristol, BS8 2BN, United Kingdom
Gunnhild Åberge Vie
1K.G. Jebsen Center for Genetic Epidemiology, Department of Public Health and Nursing, NTNU, Norwegian University of Science and Technology, Norway
Yoonsu Cho
2Medical Research Council Integrative Epidemiology Unit, University of Bristol, BS8 2BN, United Kingdom
4Population Health Sciences, Bristol Medical School, University of Bristol, Barley House, Oakfield Grove, Bristol, BS8 2BN, United Kingdom
Laura D Howe
2Medical Research Council Integrative Epidemiology Unit, University of Bristol, BS8 2BN, United Kingdom
4Population Health Sciences, Bristol Medical School, University of Bristol, Barley House, Oakfield Grove, Bristol, BS8 2BN, United Kingdom
Amanda Hughes
2Medical Research Council Integrative Epidemiology Unit, University of Bristol, BS8 2BN, United Kingdom
4Population Health Sciences, Bristol Medical School, University of Bristol, Barley House, Oakfield Grove, Bristol, BS8 2BN, United Kingdom
Dorret I Boomsma
6Netherlands Twin Register, Department of Biological Psychology, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands
Alexandra Havdahl
2Medical Research Council Integrative Epidemiology Unit, University of Bristol, BS8 2BN, United Kingdom
7Nic Waals Institute, Lovisenberg Diaconal Hospital Spångbergveien 25, 0853 Oslo, Norway
8Department of Mental Disorders, Norwegian Institute of Public Health, Sandakerveien 24C, 0473 Oslo, Norway
John Hopper
9The University of Melbourne, 207 Bouverie St, Carlton, Victoria, 3010, Australia
Michael Neale
10Virginia Institute for Psychiatric and Behavior Genetics, Virginia Commonwealth University, Richmond, Virginia, USA
Michel G Nivard
6Netherlands Twin Register, Department of Biological Psychology, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands
Nancy L Pedersen
11Karolinska Institutet, Dept of Medical Epidemiology and Biostatistics, Stockholm, Sweden
Chandra A Reynolds
12Department of Psychology, University of California Riverside, Riverside, CA, USA
Elliot M Tucker-Drob
13Department of Psychology and Population Research Center, University of Texas at Austin, 108 E. Dean Keeton Stop A8000, Austin TX 78712 USA
Andrew Grotzinger
13Department of Psychology and Population Research Center, University of Texas at Austin, 108 E. Dean Keeton Stop A8000, Austin TX 78712 USA
Laurence Howe
2Medical Research Council Integrative Epidemiology Unit, University of Bristol, BS8 2BN, United Kingdom
4Population Health Sciences, Bristol Medical School, University of Bristol, Barley House, Oakfield Grove, Bristol, BS8 2BN, United Kingdom
Tim Morris
2Medical Research Council Integrative Epidemiology Unit, University of Bristol, BS8 2BN, United Kingdom
4Population Health Sciences, Bristol Medical School, University of Bristol, Barley House, Oakfield Grove, Bristol, BS8 2BN, United Kingdom
Shuai Li
14Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne 207 Bouverie Street, Carlton, Victoria 3053, Australia
15Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge CB1 8RN, United Kingdom
Wei-Min Chen
17Center for public health genomics, Department of public health sciences, University of Virginia, Charlottesville, VA, USA
Johan Håkon Bjørngaard
1K.G. Jebsen Center for Genetic Epidemiology, Department of Public Health and Nursing, NTNU, Norwegian University of Science and Technology, Norway
Kristian Hveem
1K.G. Jebsen Center for Genetic Epidemiology, Department of Public Health and Nursing, NTNU, Norwegian University of Science and Technology, Norway
Cristen Willer
18Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, USA
19Department of Internal Medicine, University of Michigan, Ann Arbor, MI, US
20Department of Human Genetics, University of Michigan, Ann Arbor, USA
David M Evans
2Medical Research Council Integrative Epidemiology Unit, University of Bristol, BS8 2BN, United Kingdom
21University of Queensland Diamantina Institute, Translational Research Institute, Brisbane, Queensland, Australia
Jaakko Kaprio
22Department of Public Health, University of Helsinki, Helsinki, Finland
23Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland
Bjørn Olav Åsvol
24Department of Endocrinology, St Olavs Hospital, Trondheim University Hospital, Trondheim, Norway
George Davey Smith
2Medical Research Council Integrative Epidemiology Unit, University of Bristol, BS8 2BN, United Kingdom
4Population Health Sciences, Bristol Medical School, University of Bristol, Barley House, Oakfield Grove, Bristol, BS8 2BN, United Kingdom
Bjørn Olav Åsvold
1K.G. Jebsen Center for Genetic Epidemiology, Department of Public Health and Nursing, NTNU, Norwegian University of Science and Technology, Norway
24Department of Endocrinology, St Olavs Hospital, Trondheim University Hospital, Trondheim, Norway
Gibran Hemani
2Medical Research Council Integrative Epidemiology Unit, University of Bristol, BS8 2BN, United Kingdom
4Population Health Sciences, Bristol Medical School, University of Bristol, Barley House, Oakfield Grove, Bristol, BS8 2BN, United Kingdom
Neil M Davies
2Medical Research Council Integrative Epidemiology Unit, University of Bristol, BS8 2BN, United Kingdom
4Population Health Sciences, Bristol Medical School, University of Bristol, Barley House, Oakfield Grove, Bristol, BS8 2BN, United Kingdom
Posted July 05, 2019.
Within-family studies for Mendelian randomization: avoiding dynastic, assortative mating, and population stratification biases
Ben Brumpton, Eleanor Sanderson, Fernando Pires Hartwig, Sean Harrison, Gunnhild Åberge Vie, Yoonsu Cho, Laura D Howe, Amanda Hughes, Dorret I Boomsma, Alexandra Havdahl, John Hopper, Michael Neale, Michel G Nivard, Nancy L Pedersen, Chandra A Reynolds, Elliot M Tucker-Drob, Andrew Grotzinger, Laurence Howe, Tim Morris, Shuai Li, MR within-family Consortium, Wei-Min Chen, Johan Håkon Bjørngaard, Kristian Hveem, Cristen Willer, David M Evans, Jaakko Kaprio, Bjørn Olav Åsvol, George Davey Smith, Bjørn Olav Åsvold, Gibran Hemani, Neil M Davies
bioRxiv 602516; doi: https://doi.org/10.1101/602516
Within-family studies for Mendelian randomization: avoiding dynastic, assortative mating, and population stratification biases
Ben Brumpton, Eleanor Sanderson, Fernando Pires Hartwig, Sean Harrison, Gunnhild Åberge Vie, Yoonsu Cho, Laura D Howe, Amanda Hughes, Dorret I Boomsma, Alexandra Havdahl, John Hopper, Michael Neale, Michel G Nivard, Nancy L Pedersen, Chandra A Reynolds, Elliot M Tucker-Drob, Andrew Grotzinger, Laurence Howe, Tim Morris, Shuai Li, MR within-family Consortium, Wei-Min Chen, Johan Håkon Bjørngaard, Kristian Hveem, Cristen Willer, David M Evans, Jaakko Kaprio, Bjørn Olav Åsvol, George Davey Smith, Bjørn Olav Åsvold, Gibran Hemani, Neil M Davies
bioRxiv 602516; doi: https://doi.org/10.1101/602516
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