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Multivariate GWAS of psychiatric disorders and their cardinal symptoms reveal two dimensions of cross-cutting genetic liabilities
View ORCID ProfileTravis T. Mallard, View ORCID ProfileRichard K. Linnér, Andrew D. Grotzinger, Sandra Sanchez-Roige, Jakob Seidlitz, Aysu Okbay, Ronald de Vlaming, S. Fleur W. Meddens, Bipolar Disorder Working Group of the Psychiatric Genomics Consortium, Abraham A. Palmer, Lea K. Davis, Elliot M. Tucker-Drob, Kenneth S. Kendler, Matthew C. Keller, Philipp D. Koellinger, K. Paige Harden
doi: https://doi.org/10.1101/603134
Travis T. Mallard
1Department of Psychology, University of Texas at Austin, Austin, TX, USA
Richard K. Linnér
2Department of Economics, School of Business and Economics, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands
3Autism and Developmental Medicine Institute, Geisinger, Lewisburg, PA, USA
Andrew D. Grotzinger
1Department of Psychology, University of Texas at Austin, Austin, TX, USA
Sandra Sanchez-Roige
4Department of Psychiatry, University of California San Diego, La Jolla, CA, USA
Jakob Seidlitz
5Department of Child and Adolescent Psychiatry and Behavioral Science, Children’s Hospital of Philadelphia, Philadelphia, PA, USA
6Department of Psychiatry, University of Pennsylvania, Philadelphia, PA, USA
Aysu Okbay
2Department of Economics, School of Business and Economics, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands
Ronald de Vlaming
2Department of Economics, School of Business and Economics, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands
S. Fleur W. Meddens
7Erasmus University Rotterdam Institute for Behavior and Biology, Erasmus School of Economics, Erasmus University Rotterdam, Rotterdam, The Netherlands
Abraham A. Palmer
4Department of Psychiatry, University of California San Diego, La Jolla, CA, USA
8Institute for Genomic Medicine, University of California San Diego, La Jolla, CA, USA
Lea K. Davis
9Division of Genetic Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA
10Vanderbilt Genetics Institute, Vanderbilt University Medical Center, Nashville, TN, USA
Elliot M. Tucker-Drob
1Department of Psychology, University of Texas at Austin, Austin, TX, USA
11Population Research Center, University of Texas at Austin, Austin, TX USA
Kenneth S. Kendler
12Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, VA, USA
13Department of Psychiatry, Medical College of Virginia/Virginia Commonwealth University, Richmond, VA, USA
Matthew C. Keller
14Institute for Behavioral Genetics, University of Colorado Boulder, Boulder, CO, USA
15Department of Psychology and Neuroscience, University of Colorado Boulder, Boulder, CO, USA
Philipp D. Koellinger
2Department of Economics, School of Business and Economics, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands
K. Paige Harden
1Department of Psychology, University of Texas at Austin, Austin, TX, USA
11Population Research Center, University of Texas at Austin, Austin, TX USA
Posted September 08, 2020.
Multivariate GWAS of psychiatric disorders and their cardinal symptoms reveal two dimensions of cross-cutting genetic liabilities
Travis T. Mallard, Richard K. Linnér, Andrew D. Grotzinger, Sandra Sanchez-Roige, Jakob Seidlitz, Aysu Okbay, Ronald de Vlaming, S. Fleur W. Meddens, Bipolar Disorder Working Group of the Psychiatric Genomics Consortium, Abraham A. Palmer, Lea K. Davis, Elliot M. Tucker-Drob, Kenneth S. Kendler, Matthew C. Keller, Philipp D. Koellinger, K. Paige Harden
bioRxiv 603134; doi: https://doi.org/10.1101/603134
Multivariate GWAS of psychiatric disorders and their cardinal symptoms reveal two dimensions of cross-cutting genetic liabilities
Travis T. Mallard, Richard K. Linnér, Andrew D. Grotzinger, Sandra Sanchez-Roige, Jakob Seidlitz, Aysu Okbay, Ronald de Vlaming, S. Fleur W. Meddens, Bipolar Disorder Working Group of the Psychiatric Genomics Consortium, Abraham A. Palmer, Lea K. Davis, Elliot M. Tucker-Drob, Kenneth S. Kendler, Matthew C. Keller, Philipp D. Koellinger, K. Paige Harden
bioRxiv 603134; doi: https://doi.org/10.1101/603134
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