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A Proteomic Atlas of Senescence-Associated Secretomes for Aging Biomarker Development

View ORCID ProfileNathan Basisty, Abhijit Kale, Okhee Jeon, Chisaka Kuehnemann, Therese Payne, Chirag Rao, Anja Holtz, Samah Shah, Luigi Ferrucci, Judith Campisi, Birgit Schilling
doi: https://doi.org/10.1101/604306
Nathan Basisty
1The Buck Institute for Research on Aging, Novato, California 94947, USA
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Abhijit Kale
1The Buck Institute for Research on Aging, Novato, California 94947, USA
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Okhee Jeon
1The Buck Institute for Research on Aging, Novato, California 94947, USA
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Chisaka Kuehnemann
1The Buck Institute for Research on Aging, Novato, California 94947, USA
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Therese Payne
1The Buck Institute for Research on Aging, Novato, California 94947, USA
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Chirag Rao
1The Buck Institute for Research on Aging, Novato, California 94947, USA
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Anja Holtz
1The Buck Institute for Research on Aging, Novato, California 94947, USA
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Samah Shah
1The Buck Institute for Research on Aging, Novato, California 94947, USA
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Luigi Ferrucci
3National Institute on Aging, Bethesda, Maryland 20892, USA
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Judith Campisi
1The Buck Institute for Research on Aging, Novato, California 94947, USA
2Lawrence Berkeley Laboratory, University of California, Berkeley, California 94720, USA
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Birgit Schilling
1The Buck Institute for Research on Aging, Novato, California 94947, USA
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  • For correspondence: bschilling@buckinstitute.org
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SUMMARY

The senescence-associated secretory phenotype (SASP) has recently emerged as both a driver of, and promising therapeutic target for, multiple age-related conditions, ranging from neurodegeneration to cancer. The complexity of the SASP, typically monitored by a few dozen secreted proteins, has been greatly underappreciated, and a small set of factors cannot explain the diverse phenotypes it produces in vivo. Here, we present ‘SASP Atlas’, a comprehensive proteomic database of soluble and exosome SASP factors originating from multiple senescence inducers and cell types. Each profile consists of hundreds of largely distinct proteins, but also includes a subset of proteins elevated in all SASPs. Based on our analyses, we propose several candidate biomarkers of cellular senescence, including GDF15, STC1 and SERPINs. This resource will facilitate identification of proteins that drive specific senescence-associated phenotypes and catalog potential senescence biomarkers to assess the burden, originating stimulus and tissue of senescent cells in vivo.

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The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC-ND 4.0 International license.
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Posted April 10, 2019.
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A Proteomic Atlas of Senescence-Associated Secretomes for Aging Biomarker Development
Nathan Basisty, Abhijit Kale, Okhee Jeon, Chisaka Kuehnemann, Therese Payne, Chirag Rao, Anja Holtz, Samah Shah, Luigi Ferrucci, Judith Campisi, Birgit Schilling
bioRxiv 604306; doi: https://doi.org/10.1101/604306
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A Proteomic Atlas of Senescence-Associated Secretomes for Aging Biomarker Development
Nathan Basisty, Abhijit Kale, Okhee Jeon, Chisaka Kuehnemann, Therese Payne, Chirag Rao, Anja Holtz, Samah Shah, Luigi Ferrucci, Judith Campisi, Birgit Schilling
bioRxiv 604306; doi: https://doi.org/10.1101/604306

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