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Exploring the association of collaterals and vessel density using optical coherence tomography angiography in retinal vein occlusions

Hee Eun Lee, Yiyang Wang, Alaa E. Fayed, View ORCID ProfileAmani A. Fawzi
doi: https://doi.org/10.1101/604983
Hee Eun Lee
1Department of Ophthalmology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois
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Yiyang Wang
1Department of Ophthalmology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois
2School of Computing, College of Computing and Digital Media, DePaul University, Chicago, Illinois
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Alaa E. Fayed
1Department of Ophthalmology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois
3Department of Ophthalmology, Kasr Al-Ainy School of Medicine, Cairo University, Egypt
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Amani A. Fawzi
1Department of Ophthalmology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois
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  • ORCID record for Amani A. Fawzi
  • For correspondence: afawzimd@gmail.com
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Abstract

Purpose Using optical coherence tomography angiography (OCTA) to characterize the types of collaterals in eyes with retinal vein occlusion (RVO) and further investigate their correlations with vessel densities of the superficial (SCP) and the deep capillary plexus (DCP).

Methods This cross-sectional study included 25 eyes of 23 patients with RVO. 3 × 3 mm2 OCTA macular scans were used to quantify the parafoveal vessel density (VD) of the SCP and DCP, and to classify the collaterals into one of four types (true superficial, true deep, superficial diving, and foveal collateral). Poisson regression model was used to identify significant associations between parafoveal VD and collaterals. We further compared parafoveal VD between subgroups classified by the presence of specific collateral types based on the results of a clustering algorithm.

Results 16 of 25 eyes (64%) developed collaterals. Of the 43 collateral vessels analyzed, 12/19 (63%) true superficial collaterals developed in eyes with central RVO, while all 10 superficial diving collaterals (100%) developed in eyes with branch RVO. Located exclusively in the SCP, true superficial collaterals were all arteriovenous (A-V), while diving collaterals were all veno-venular (V-V). We found a significant negative correlation between SCP VD and the total number of collaterals (R2 = 0.648, P < 0.001) for the entire study cohort. Furthermore, BRVO eyes that developed superficial diving collaterals and CRVO eyes that developed true superficial collaterals demonstrated statistically significant decrease in SCP VD (P-value = 0.014) and DCP VD (P-value = 0.030), respectively, as compared to their counterparts.

Conclusion Our data shows that decreased capillary perfusion in RVO is associated with the development of collaterals, while the RVO type largely dictates the type of collateral that ultimately develops.

Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY 4.0 International license.
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Posted April 10, 2019.
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Exploring the association of collaterals and vessel density using optical coherence tomography angiography in retinal vein occlusions
Hee Eun Lee, Yiyang Wang, Alaa E. Fayed, Amani A. Fawzi
bioRxiv 604983; doi: https://doi.org/10.1101/604983
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Exploring the association of collaterals and vessel density using optical coherence tomography angiography in retinal vein occlusions
Hee Eun Lee, Yiyang Wang, Alaa E. Fayed, Amani A. Fawzi
bioRxiv 604983; doi: https://doi.org/10.1101/604983

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