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A reference map of the human protein interactome

View ORCID ProfileKatja Luck, Dae-Kyum Kim, View ORCID ProfileLuke Lambourne, View ORCID ProfileKerstin Spirohn, Bridget E. Begg, Wenting Bian, Ruth Brignall, Tiziana Cafarelli, Francisco J. Campos-Laborie, Benoit Charloteaux, Dongsic Choi, Atina G. Cote, Meaghan Daley, Steven Deimling, Alice Desbuleux, Amélie Dricot, Marinella Gebbia, Madeleine F. Hardy, Nishka Kishore, Jennifer J. Knapp, István A. Kovács, Irma Lemmens, Miles W. Mee, Joseph C. Mellor, Carl Pollis, Carles Pons, Aaron D. Richardson, Sadie Schlabach, Bridget Teeking, Anupama Yadav, Mariana Babor, Dawit Balcha, Omer Basha, Christian Bowman-Colin, Suet-Feung Chin, Soon Gang Choi, Claudia Colabella, Georges Coppin, Cassandra D’Amata, David De Ridder, Steffi De Rouck, Miquel Duran-Frigola, Hanane Ennajdaoui, Florian Goebels, Liana Goehring, Anjali Gopal, Ghazal Haddad, Elodie Hatchi, Mohamed Helmy, Yves Jacob, Yoseph Kassa, Serena Landini, Roujia Li, Natascha van Lieshout, Andrew MacWilliams, Dylan Markey, Joseph N. Paulson, Sudharshan Rangarajan, John Rasla, Ashyad Rayhan, Thomas Rolland, Adriana San-Miguel, Yun Shen, Dayag Sheykhkarimli, Gloria M. Sheynkman, Eyal Simonovsky, Murat Taşan, Alexander Tejeda, Jean-Claude Twizere, Yang Wang, Robert J. Weatheritt, Jochen Weile, Yu Xia, Xinping Yang, Esti Yeger-Lotem, Quan Zhong, Patrick Aloy, Gary D. Bader, Javier De Las Rivas, Suzanne Gaudet, View ORCID ProfileTong Hao, Janusz Rak, Jan Tavernier, Vincent Tropepe, View ORCID ProfileDavid E. Hill, View ORCID ProfileMarc Vidal, View ORCID ProfileFrederick P. Roth, View ORCID ProfileMichael A. Calderwood
doi: https://doi.org/10.1101/605451
Katja Luck
1Center for Cancer Systems Biology (CCSB), Dana-Farber Cancer Institute, Boston, MA, USA
2Department of Genetics, Blavatnik Institute, Harvard Medical School, Boston, MA, USA
3Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA
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  • ORCID record for Katja Luck
Dae-Kyum Kim
1Center for Cancer Systems Biology (CCSB), Dana-Farber Cancer Institute, Boston, MA, USA
4The Donnelly Centre, University of Toronto, Toronto, ON, Canada
5Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada
6Lunenfeld Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, ON, Canada
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Luke Lambourne
1Center for Cancer Systems Biology (CCSB), Dana-Farber Cancer Institute, Boston, MA, USA
2Department of Genetics, Blavatnik Institute, Harvard Medical School, Boston, MA, USA
3Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA
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  • ORCID record for Luke Lambourne
Kerstin Spirohn
1Center for Cancer Systems Biology (CCSB), Dana-Farber Cancer Institute, Boston, MA, USA
2Department of Genetics, Blavatnik Institute, Harvard Medical School, Boston, MA, USA
3Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA
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  • ORCID record for Kerstin Spirohn
Bridget E. Begg
1Center for Cancer Systems Biology (CCSB), Dana-Farber Cancer Institute, Boston, MA, USA
2Department of Genetics, Blavatnik Institute, Harvard Medical School, Boston, MA, USA
3Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA
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Wenting Bian
1Center for Cancer Systems Biology (CCSB), Dana-Farber Cancer Institute, Boston, MA, USA
2Department of Genetics, Blavatnik Institute, Harvard Medical School, Boston, MA, USA
3Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA
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Ruth Brignall
1Center for Cancer Systems Biology (CCSB), Dana-Farber Cancer Institute, Boston, MA, USA
2Department of Genetics, Blavatnik Institute, Harvard Medical School, Boston, MA, USA
3Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA
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Tiziana Cafarelli
1Center for Cancer Systems Biology (CCSB), Dana-Farber Cancer Institute, Boston, MA, USA
2Department of Genetics, Blavatnik Institute, Harvard Medical School, Boston, MA, USA
3Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA
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Francisco J. Campos-Laborie
7Cancer Research Center (CiC-IBMCC, CSIC/USAL), Consejo Superior de Investigaciones Científicas (CSIC) and University of Salamanca (USAL), Salamanca, Spain
8Institute for Biomedical Research of Salamanca (IBSAL), Salamanca, Spain
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Benoit Charloteaux
1Center for Cancer Systems Biology (CCSB), Dana-Farber Cancer Institute, Boston, MA, USA
2Department of Genetics, Blavatnik Institute, Harvard Medical School, Boston, MA, USA
3Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA
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Dongsic Choi
9The Research Institute of the McGill University Health Centre, Montreal, QC, Canada
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Atina G. Cote
1Center for Cancer Systems Biology (CCSB), Dana-Farber Cancer Institute, Boston, MA, USA
4The Donnelly Centre, University of Toronto, Toronto, ON, Canada
5Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada
6Lunenfeld Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, ON, Canada
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Meaghan Daley
1Center for Cancer Systems Biology (CCSB), Dana-Farber Cancer Institute, Boston, MA, USA
2Department of Genetics, Blavatnik Institute, Harvard Medical School, Boston, MA, USA
3Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA
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Steven Deimling
10Department of Cell and Systems Biology, University of Toronto, Toronto, ON, Canada
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Alice Desbuleux
1Center for Cancer Systems Biology (CCSB), Dana-Farber Cancer Institute, Boston, MA, USA
2Department of Genetics, Blavatnik Institute, Harvard Medical School, Boston, MA, USA
3Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA
11Molecular Biology of Diseases, Groupe Interdisciplinaire de Génomique Appliquée (GIGA) and Laboratory of Viral Interactomes, University of Liège, Liège, Belgium
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Amélie Dricot
1Center for Cancer Systems Biology (CCSB), Dana-Farber Cancer Institute, Boston, MA, USA
2Department of Genetics, Blavatnik Institute, Harvard Medical School, Boston, MA, USA
3Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA
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Marinella Gebbia
1Center for Cancer Systems Biology (CCSB), Dana-Farber Cancer Institute, Boston, MA, USA
4The Donnelly Centre, University of Toronto, Toronto, ON, Canada
5Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada
6Lunenfeld Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, ON, Canada
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Madeleine F. Hardy
1Center for Cancer Systems Biology (CCSB), Dana-Farber Cancer Institute, Boston, MA, USA
2Department of Genetics, Blavatnik Institute, Harvard Medical School, Boston, MA, USA
3Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA
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Nishka Kishore
1Center for Cancer Systems Biology (CCSB), Dana-Farber Cancer Institute, Boston, MA, USA
4The Donnelly Centre, University of Toronto, Toronto, ON, Canada
5Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada
6Lunenfeld Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, ON, Canada
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Jennifer J. Knapp
1Center for Cancer Systems Biology (CCSB), Dana-Farber Cancer Institute, Boston, MA, USA
4The Donnelly Centre, University of Toronto, Toronto, ON, Canada
5Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada
6Lunenfeld Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, ON, Canada
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István A. Kovács
1Center for Cancer Systems Biology (CCSB), Dana-Farber Cancer Institute, Boston, MA, USA
12Network Science Institute, Northeastern University, Boston, MA, USA
13Wigner Research Centre for Physics, Institute for Solid State Physics and Optics, Budapest, Hungary
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Irma Lemmens
14Center for Medical Biotechnology, Vlaams Instituut voor Biotechnologie (VIB), Ghent, Belgium
15Cytokine Receptor Laboratory (CRL), Department of Biomolecular Medicine, Faculty of Medicine and Health Sciences, Ghent University, Ghent, Belgium
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Miles W. Mee
4The Donnelly Centre, University of Toronto, Toronto, ON, Canada
5Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada
16Department of Computer Science, University of Toronto, Toronto, ON, Canada
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Joseph C. Mellor
1Center for Cancer Systems Biology (CCSB), Dana-Farber Cancer Institute, Boston, MA, USA
4The Donnelly Centre, University of Toronto, Toronto, ON, Canada
5Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada
6Lunenfeld Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, ON, Canada
17seqWell, Inc. Beverly MA, USA
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Carl Pollis
1Center for Cancer Systems Biology (CCSB), Dana-Farber Cancer Institute, Boston, MA, USA
2Department of Genetics, Blavatnik Institute, Harvard Medical School, Boston, MA, USA
3Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA
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Carles Pons
18Institute for Research in Biomedicine (IRB Barcelona), The Barcelona Institute for Science and Technology, Barcelona, Catalonia, Spain
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Aaron D. Richardson
1Center for Cancer Systems Biology (CCSB), Dana-Farber Cancer Institute, Boston, MA, USA
2Department of Genetics, Blavatnik Institute, Harvard Medical School, Boston, MA, USA
3Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA
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Sadie Schlabach
1Center for Cancer Systems Biology (CCSB), Dana-Farber Cancer Institute, Boston, MA, USA
2Department of Genetics, Blavatnik Institute, Harvard Medical School, Boston, MA, USA
3Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA
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Bridget Teeking
1Center for Cancer Systems Biology (CCSB), Dana-Farber Cancer Institute, Boston, MA, USA
2Department of Genetics, Blavatnik Institute, Harvard Medical School, Boston, MA, USA
3Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA
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Anupama Yadav
1Center for Cancer Systems Biology (CCSB), Dana-Farber Cancer Institute, Boston, MA, USA
2Department of Genetics, Blavatnik Institute, Harvard Medical School, Boston, MA, USA
3Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA
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Mariana Babor
1Center for Cancer Systems Biology (CCSB), Dana-Farber Cancer Institute, Boston, MA, USA
4The Donnelly Centre, University of Toronto, Toronto, ON, Canada
5Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada
6Lunenfeld Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, ON, Canada
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Dawit Balcha
1Center for Cancer Systems Biology (CCSB), Dana-Farber Cancer Institute, Boston, MA, USA
2Department of Genetics, Blavatnik Institute, Harvard Medical School, Boston, MA, USA
3Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA
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Omer Basha
19Department of Clinical Biochemistry and Pharmacology, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel
20National Institute for Biotechnology in the Negev, Ben-Gurion University of the Negev, Beer-Sheva, Israel
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Christian Bowman-Colin
2Department of Genetics, Blavatnik Institute, Harvard Medical School, Boston, MA, USA
3Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA
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Suet-Feung Chin
21CRUK Cambridge Institute, University of Cambridge, Cambridge, UK
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Soon Gang Choi
1Center for Cancer Systems Biology (CCSB), Dana-Farber Cancer Institute, Boston, MA, USA
2Department of Genetics, Blavatnik Institute, Harvard Medical School, Boston, MA, USA
3Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA
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Claudia Colabella
22Department of Pharmaceutical Sciences, University of Perugia, Italy
23Istituto Zooprofilattico Sperimentale dell’Umbria e delle Marche “Togo Rosati”, Perugia, Italy
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Georges Coppin
1Center for Cancer Systems Biology (CCSB), Dana-Farber Cancer Institute, Boston, MA, USA
2Department of Genetics, Blavatnik Institute, Harvard Medical School, Boston, MA, USA
3Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA
11Molecular Biology of Diseases, Groupe Interdisciplinaire de Génomique Appliquée (GIGA) and Laboratory of Viral Interactomes, University of Liège, Liège, Belgium
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Cassandra D’Amata
10Department of Cell and Systems Biology, University of Toronto, Toronto, ON, Canada
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David De Ridder
1Center for Cancer Systems Biology (CCSB), Dana-Farber Cancer Institute, Boston, MA, USA
2Department of Genetics, Blavatnik Institute, Harvard Medical School, Boston, MA, USA
3Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA
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Steffi De Rouck
14Center for Medical Biotechnology, Vlaams Instituut voor Biotechnologie (VIB), Ghent, Belgium
15Cytokine Receptor Laboratory (CRL), Department of Biomolecular Medicine, Faculty of Medicine and Health Sciences, Ghent University, Ghent, Belgium
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Miquel Duran-Frigola
18Institute for Research in Biomedicine (IRB Barcelona), The Barcelona Institute for Science and Technology, Barcelona, Catalonia, Spain
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Hanane Ennajdaoui
1Center for Cancer Systems Biology (CCSB), Dana-Farber Cancer Institute, Boston, MA, USA
4The Donnelly Centre, University of Toronto, Toronto, ON, Canada
5Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada
6Lunenfeld Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, ON, Canada
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Florian Goebels
4The Donnelly Centre, University of Toronto, Toronto, ON, Canada
5Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada
16Department of Computer Science, University of Toronto, Toronto, ON, Canada
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Liana Goehring
2Department of Genetics, Blavatnik Institute, Harvard Medical School, Boston, MA, USA
3Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA
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Anjali Gopal
1Center for Cancer Systems Biology (CCSB), Dana-Farber Cancer Institute, Boston, MA, USA
4The Donnelly Centre, University of Toronto, Toronto, ON, Canada
5Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada
6Lunenfeld Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, ON, Canada
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Ghazal Haddad
1Center for Cancer Systems Biology (CCSB), Dana-Farber Cancer Institute, Boston, MA, USA
4The Donnelly Centre, University of Toronto, Toronto, ON, Canada
5Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada
6Lunenfeld Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, ON, Canada
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Elodie Hatchi
2Department of Genetics, Blavatnik Institute, Harvard Medical School, Boston, MA, USA
3Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA
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Mohamed Helmy
4The Donnelly Centre, University of Toronto, Toronto, ON, Canada
5Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada
16Department of Computer Science, University of Toronto, Toronto, ON, Canada
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Yves Jacob
24Département de Virologie, Unité de Génétique Moléculaire des Virus à ARN (GMVR), Institut Pasteur, UMR3569, Centre National de la Recherche Scientifique (CNRS), Paris, France
25Université Paris Diderot, Paris, France
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Yoseph Kassa
1Center for Cancer Systems Biology (CCSB), Dana-Farber Cancer Institute, Boston, MA, USA
2Department of Genetics, Blavatnik Institute, Harvard Medical School, Boston, MA, USA
3Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA
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Serena Landini
2Department of Genetics, Blavatnik Institute, Harvard Medical School, Boston, MA, USA
3Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA
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Roujia Li
1Center for Cancer Systems Biology (CCSB), Dana-Farber Cancer Institute, Boston, MA, USA
4The Donnelly Centre, University of Toronto, Toronto, ON, Canada
5Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada
6Lunenfeld Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, ON, Canada
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Natascha van Lieshout
1Center for Cancer Systems Biology (CCSB), Dana-Farber Cancer Institute, Boston, MA, USA
4The Donnelly Centre, University of Toronto, Toronto, ON, Canada
5Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada
6Lunenfeld Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, ON, Canada
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Andrew MacWilliams
1Center for Cancer Systems Biology (CCSB), Dana-Farber Cancer Institute, Boston, MA, USA
2Department of Genetics, Blavatnik Institute, Harvard Medical School, Boston, MA, USA
3Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA
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Dylan Markey
1Center for Cancer Systems Biology (CCSB), Dana-Farber Cancer Institute, Boston, MA, USA
2Department of Genetics, Blavatnik Institute, Harvard Medical School, Boston, MA, USA
3Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA
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Joseph N. Paulson
26Department of Biostatistics and Computational Biology, Dana-Farber Cancer Institute, Boston, MA, USA
27Department of Biostatistics, Harvard School of Public Health, Boston, MA, USA
28Department of Biostatistics, Product Development, Genentech Inc., South San Francisco, CA, USA
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Sudharshan Rangarajan
1Center for Cancer Systems Biology (CCSB), Dana-Farber Cancer Institute, Boston, MA, USA
2Department of Genetics, Blavatnik Institute, Harvard Medical School, Boston, MA, USA
3Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA
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John Rasla
1Center for Cancer Systems Biology (CCSB), Dana-Farber Cancer Institute, Boston, MA, USA
2Department of Genetics, Blavatnik Institute, Harvard Medical School, Boston, MA, USA
3Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA
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Ashyad Rayhan
1Center for Cancer Systems Biology (CCSB), Dana-Farber Cancer Institute, Boston, MA, USA
4The Donnelly Centre, University of Toronto, Toronto, ON, Canada
5Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada
6Lunenfeld Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, ON, Canada
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Thomas Rolland
1Center for Cancer Systems Biology (CCSB), Dana-Farber Cancer Institute, Boston, MA, USA
2Department of Genetics, Blavatnik Institute, Harvard Medical School, Boston, MA, USA
3Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA
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Adriana San-Miguel
1Center for Cancer Systems Biology (CCSB), Dana-Farber Cancer Institute, Boston, MA, USA
2Department of Genetics, Blavatnik Institute, Harvard Medical School, Boston, MA, USA
3Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA
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Yun Shen
1Center for Cancer Systems Biology (CCSB), Dana-Farber Cancer Institute, Boston, MA, USA
2Department of Genetics, Blavatnik Institute, Harvard Medical School, Boston, MA, USA
3Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA
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Dayag Sheykhkarimli
1Center for Cancer Systems Biology (CCSB), Dana-Farber Cancer Institute, Boston, MA, USA
4The Donnelly Centre, University of Toronto, Toronto, ON, Canada
5Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada
6Lunenfeld Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, ON, Canada
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Gloria M. Sheynkman
1Center for Cancer Systems Biology (CCSB), Dana-Farber Cancer Institute, Boston, MA, USA
2Department of Genetics, Blavatnik Institute, Harvard Medical School, Boston, MA, USA
3Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA
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Eyal Simonovsky
19Department of Clinical Biochemistry and Pharmacology, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel
20National Institute for Biotechnology in the Negev, Ben-Gurion University of the Negev, Beer-Sheva, Israel
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Murat Taşan
1Center for Cancer Systems Biology (CCSB), Dana-Farber Cancer Institute, Boston, MA, USA
4The Donnelly Centre, University of Toronto, Toronto, ON, Canada
5Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada
6Lunenfeld Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, ON, Canada
16Department of Computer Science, University of Toronto, Toronto, ON, Canada
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Alexander Tejeda
1Center for Cancer Systems Biology (CCSB), Dana-Farber Cancer Institute, Boston, MA, USA
2Department of Genetics, Blavatnik Institute, Harvard Medical School, Boston, MA, USA
3Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA
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Jean-Claude Twizere
11Molecular Biology of Diseases, Groupe Interdisciplinaire de Génomique Appliquée (GIGA) and Laboratory of Viral Interactomes, University of Liège, Liège, Belgium
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Yang Wang
1Center for Cancer Systems Biology (CCSB), Dana-Farber Cancer Institute, Boston, MA, USA
2Department of Genetics, Blavatnik Institute, Harvard Medical School, Boston, MA, USA
3Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA
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Robert J. Weatheritt
4The Donnelly Centre, University of Toronto, Toronto, ON, Canada
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Jochen Weile
1Center for Cancer Systems Biology (CCSB), Dana-Farber Cancer Institute, Boston, MA, USA
4The Donnelly Centre, University of Toronto, Toronto, ON, Canada
5Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada
6Lunenfeld Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, ON, Canada
16Department of Computer Science, University of Toronto, Toronto, ON, Canada
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Yu Xia
1Center for Cancer Systems Biology (CCSB), Dana-Farber Cancer Institute, Boston, MA, USA
29Department of Bioengineering, McGill University, Montreal, QC, Canada
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Xinping Yang
1Center for Cancer Systems Biology (CCSB), Dana-Farber Cancer Institute, Boston, MA, USA
2Department of Genetics, Blavatnik Institute, Harvard Medical School, Boston, MA, USA
3Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA
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Esti Yeger-Lotem
19Department of Clinical Biochemistry and Pharmacology, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel
20National Institute for Biotechnology in the Negev, Ben-Gurion University of the Negev, Beer-Sheva, Israel
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Quan Zhong
1Center for Cancer Systems Biology (CCSB), Dana-Farber Cancer Institute, Boston, MA, USA
2Department of Genetics, Blavatnik Institute, Harvard Medical School, Boston, MA, USA
3Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA
30Department of Biological Sciences, Wright State University, Dayton, OH, USA
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Patrick Aloy
18Institute for Research in Biomedicine (IRB Barcelona), The Barcelona Institute for Science and Technology, Barcelona, Catalonia, Spain
31Institució Catalana de Recerca i Estudis Avançats (ICREA), Barcelona, Catalonia, Spain
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Gary D. Bader
4The Donnelly Centre, University of Toronto, Toronto, ON, Canada
5Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada
16Department of Computer Science, University of Toronto, Toronto, ON, Canada
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Javier De Las Rivas
7Cancer Research Center (CiC-IBMCC, CSIC/USAL), Consejo Superior de Investigaciones Científicas (CSIC) and University of Salamanca (USAL), Salamanca, Spain
8Institute for Biomedical Research of Salamanca (IBSAL), Salamanca, Spain
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Suzanne Gaudet
1Center for Cancer Systems Biology (CCSB), Dana-Farber Cancer Institute, Boston, MA, USA
2Department of Genetics, Blavatnik Institute, Harvard Medical School, Boston, MA, USA
3Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA
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Tong Hao
1Center for Cancer Systems Biology (CCSB), Dana-Farber Cancer Institute, Boston, MA, USA
2Department of Genetics, Blavatnik Institute, Harvard Medical School, Boston, MA, USA
3Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA
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  • ORCID record for Tong Hao
Janusz Rak
9The Research Institute of the McGill University Health Centre, Montreal, QC, Canada
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Jan Tavernier
14Center for Medical Biotechnology, Vlaams Instituut voor Biotechnologie (VIB), Ghent, Belgium
15Cytokine Receptor Laboratory (CRL), Department of Biomolecular Medicine, Faculty of Medicine and Health Sciences, Ghent University, Ghent, Belgium
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Vincent Tropepe
10Department of Cell and Systems Biology, University of Toronto, Toronto, ON, Canada
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David E. Hill
1Center for Cancer Systems Biology (CCSB), Dana-Farber Cancer Institute, Boston, MA, USA
2Department of Genetics, Blavatnik Institute, Harvard Medical School, Boston, MA, USA
3Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA
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  • ORCID record for David E. Hill
  • For correspondence: michael_calderwood@dfci.harvard.edu fritz.roth@utoronto.ca marc_vidal@dfci.harvard.edu david_hill@dfci.harvard.edu
Marc Vidal
1Center for Cancer Systems Biology (CCSB), Dana-Farber Cancer Institute, Boston, MA, USA
2Department of Genetics, Blavatnik Institute, Harvard Medical School, Boston, MA, USA
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  • For correspondence: michael_calderwood@dfci.harvard.edu fritz.roth@utoronto.ca marc_vidal@dfci.harvard.edu david_hill@dfci.harvard.edu
Frederick P. Roth
1Center for Cancer Systems Biology (CCSB), Dana-Farber Cancer Institute, Boston, MA, USA
4The Donnelly Centre, University of Toronto, Toronto, ON, Canada
5Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada
6Lunenfeld Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, ON, Canada
16Department of Computer Science, University of Toronto, Toronto, ON, Canada
32Canadian Institute for Advanced Research (CIFAR), Toronto, ON, Canada
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  • For correspondence: michael_calderwood@dfci.harvard.edu fritz.roth@utoronto.ca marc_vidal@dfci.harvard.edu david_hill@dfci.harvard.edu
Michael A. Calderwood
1Center for Cancer Systems Biology (CCSB), Dana-Farber Cancer Institute, Boston, MA, USA
2Department of Genetics, Blavatnik Institute, Harvard Medical School, Boston, MA, USA
3Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA
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  • For correspondence: michael_calderwood@dfci.harvard.edu fritz.roth@utoronto.ca marc_vidal@dfci.harvard.edu david_hill@dfci.harvard.edu
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Abstract

Global insights into cellular organization and function require comprehensive understanding of interactome networks. Similar to how a reference genome sequence revolutionized human genetics, a reference map of the human interactome network is critical to fully understand genotype-phenotype relationships. Here we present the first human “all-by-all” binary reference interactome map, or “HuRI”. With ~53,000 high-quality protein-protein interactions (PPIs), HuRI is approximately four times larger than the information curated from small-scale studies available in the literature. Integrating HuRI with genome, transcriptome and proteome data enables the study of cellular function within essentially any physiological or pathological cellular context. We demonstrate the use of HuRI in identifying specific subcellular roles of PPIs and protein function modulation via splicing during brain development. Inferred tissue-specific networks reveal general principles for the formation of cellular context-specific functions and elucidate potential molecular mechanisms underlying tissue-specific phenotypes of Mendelian diseases. HuRI thus represents an unprecedented, systematic reference linking genomic variation to phenotypic outcomes.

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Posted April 19, 2019.
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A reference map of the human protein interactome
Katja Luck, Dae-Kyum Kim, Luke Lambourne, Kerstin Spirohn, Bridget E. Begg, Wenting Bian, Ruth Brignall, Tiziana Cafarelli, Francisco J. Campos-Laborie, Benoit Charloteaux, Dongsic Choi, Atina G. Cote, Meaghan Daley, Steven Deimling, Alice Desbuleux, Amélie Dricot, Marinella Gebbia, Madeleine F. Hardy, Nishka Kishore, Jennifer J. Knapp, István A. Kovács, Irma Lemmens, Miles W. Mee, Joseph C. Mellor, Carl Pollis, Carles Pons, Aaron D. Richardson, Sadie Schlabach, Bridget Teeking, Anupama Yadav, Mariana Babor, Dawit Balcha, Omer Basha, Christian Bowman-Colin, Suet-Feung Chin, Soon Gang Choi, Claudia Colabella, Georges Coppin, Cassandra D’Amata, David De Ridder, Steffi De Rouck, Miquel Duran-Frigola, Hanane Ennajdaoui, Florian Goebels, Liana Goehring, Anjali Gopal, Ghazal Haddad, Elodie Hatchi, Mohamed Helmy, Yves Jacob, Yoseph Kassa, Serena Landini, Roujia Li, Natascha van Lieshout, Andrew MacWilliams, Dylan Markey, Joseph N. Paulson, Sudharshan Rangarajan, John Rasla, Ashyad Rayhan, Thomas Rolland, Adriana San-Miguel, Yun Shen, Dayag Sheykhkarimli, Gloria M. Sheynkman, Eyal Simonovsky, Murat Taşan, Alexander Tejeda, Jean-Claude Twizere, Yang Wang, Robert J. Weatheritt, Jochen Weile, Yu Xia, Xinping Yang, Esti Yeger-Lotem, Quan Zhong, Patrick Aloy, Gary D. Bader, Javier De Las Rivas, Suzanne Gaudet, Tong Hao, Janusz Rak, Jan Tavernier, Vincent Tropepe, David E. Hill, Marc Vidal, Frederick P. Roth, Michael A. Calderwood
bioRxiv 605451; doi: https://doi.org/10.1101/605451
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A reference map of the human protein interactome
Katja Luck, Dae-Kyum Kim, Luke Lambourne, Kerstin Spirohn, Bridget E. Begg, Wenting Bian, Ruth Brignall, Tiziana Cafarelli, Francisco J. Campos-Laborie, Benoit Charloteaux, Dongsic Choi, Atina G. Cote, Meaghan Daley, Steven Deimling, Alice Desbuleux, Amélie Dricot, Marinella Gebbia, Madeleine F. Hardy, Nishka Kishore, Jennifer J. Knapp, István A. Kovács, Irma Lemmens, Miles W. Mee, Joseph C. Mellor, Carl Pollis, Carles Pons, Aaron D. Richardson, Sadie Schlabach, Bridget Teeking, Anupama Yadav, Mariana Babor, Dawit Balcha, Omer Basha, Christian Bowman-Colin, Suet-Feung Chin, Soon Gang Choi, Claudia Colabella, Georges Coppin, Cassandra D’Amata, David De Ridder, Steffi De Rouck, Miquel Duran-Frigola, Hanane Ennajdaoui, Florian Goebels, Liana Goehring, Anjali Gopal, Ghazal Haddad, Elodie Hatchi, Mohamed Helmy, Yves Jacob, Yoseph Kassa, Serena Landini, Roujia Li, Natascha van Lieshout, Andrew MacWilliams, Dylan Markey, Joseph N. Paulson, Sudharshan Rangarajan, John Rasla, Ashyad Rayhan, Thomas Rolland, Adriana San-Miguel, Yun Shen, Dayag Sheykhkarimli, Gloria M. Sheynkman, Eyal Simonovsky, Murat Taşan, Alexander Tejeda, Jean-Claude Twizere, Yang Wang, Robert J. Weatheritt, Jochen Weile, Yu Xia, Xinping Yang, Esti Yeger-Lotem, Quan Zhong, Patrick Aloy, Gary D. Bader, Javier De Las Rivas, Suzanne Gaudet, Tong Hao, Janusz Rak, Jan Tavernier, Vincent Tropepe, David E. Hill, Marc Vidal, Frederick P. Roth, Michael A. Calderwood
bioRxiv 605451; doi: https://doi.org/10.1101/605451

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