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Spontaneous isomerization of long-lived proteins provides a molecular mechanism for the lysosomal failure observed in Alzheimer’s disease

Tyler R. Lambeth, Dylan L. Riggs, Lance E. Talbert, Jin Tang, Emily Coburn, Amrik S. Kang, Jessica Noll, Catherine Augello, Byron D. Ford, Ryan R. Julian
doi: https://doi.org/10.1101/605626
Tyler R. Lambeth
1Department of Chemistry, University of California, Riverside, California 92521, United States
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Dylan L. Riggs
1Department of Chemistry, University of California, Riverside, California 92521, United States
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Lance E. Talbert
1Department of Chemistry, University of California, Riverside, California 92521, United States
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Jin Tang
1Department of Chemistry, University of California, Riverside, California 92521, United States
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Emily Coburn
1Department of Chemistry, University of California, Riverside, California 92521, United States
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Amrik S. Kang
1Department of Chemistry, University of California, Riverside, California 92521, United States
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Jessica Noll
2Division of Biomedical Sciences, University of California, Riverside, California 92521
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Catherine Augello
2Division of Biomedical Sciences, University of California, Riverside, California 92521
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Byron D. Ford
2Division of Biomedical Sciences, University of California, Riverside, California 92521
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Ryan R. Julian
1Department of Chemistry, University of California, Riverside, California 92521, United States
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  • For correspondence: ryan.julian@ucr.edu
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Posted April 12, 2019.
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Spontaneous isomerization of long-lived proteins provides a molecular mechanism for the lysosomal failure observed in Alzheimer’s disease
Tyler R. Lambeth, Dylan L. Riggs, Lance E. Talbert, Jin Tang, Emily Coburn, Amrik S. Kang, Jessica Noll, Catherine Augello, Byron D. Ford, Ryan R. Julian
bioRxiv 605626; doi: https://doi.org/10.1101/605626
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Spontaneous isomerization of long-lived proteins provides a molecular mechanism for the lysosomal failure observed in Alzheimer’s disease
Tyler R. Lambeth, Dylan L. Riggs, Lance E. Talbert, Jin Tang, Emily Coburn, Amrik S. Kang, Jessica Noll, Catherine Augello, Byron D. Ford, Ryan R. Julian
bioRxiv 605626; doi: https://doi.org/10.1101/605626

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