Spontaneous isomerization of long-lived proteins provides a molecular mechanism for the lysosomal failure observed in Alzheimer’s disease

Tyler R. Lambeth; Dylan L. Riggs; Lance E. Talbert; Jin Tang; Emily Coburn; Amrik S. Kang; Jessica Noll; Catherine Augello; Byron D. Ford; Ryan R. Julian

doi:10.1101/605626

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Spontaneous isomerization of long-lived proteins provides a molecular mechanism for the lysosomal failure observed in Alzheimer’s disease

Tyler R. Lambeth, Dylan L. Riggs, Lance E. Talbert, Jin Tang, Emily Coburn, Amrik S. Kang, Jessica Noll, Catherine Augello, Byron D. Ford, Ryan R. Julian

doi: https://doi.org/10.1101/605626

Tyler R. Lambeth

1Department of Chemistry, University of California, Riverside, California 92521, United States

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Dylan L. Riggs

1Department of Chemistry, University of California, Riverside, California 92521, United States

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Lance E. Talbert

1Department of Chemistry, University of California, Riverside, California 92521, United States

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Jin Tang

1Department of Chemistry, University of California, Riverside, California 92521, United States

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Emily Coburn

1Department of Chemistry, University of California, Riverside, California 92521, United States

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Amrik S. Kang

1Department of Chemistry, University of California, Riverside, California 92521, United States

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Jessica Noll

2Division of Biomedical Sciences, University of California, Riverside, California 92521

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Catherine Augello

2Division of Biomedical Sciences, University of California, Riverside, California 92521

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Byron D. Ford

2Division of Biomedical Sciences, University of California, Riverside, California 92521

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Ryan R. Julian

1Department of Chemistry, University of California, Riverside, California 92521, United States

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For correspondence: ryan.julian@ucr.edu

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Posted April 12, 2019.

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Spontaneous isomerization of long-lived proteins provides a molecular mechanism for the lysosomal failure observed in Alzheimer’s disease

Tyler R. Lambeth, Dylan L. Riggs, Lance E. Talbert, Jin Tang, Emily Coburn, Amrik S. Kang, Jessica Noll, Catherine Augello, Byron D. Ford, Ryan R. Julian

bioRxiv 605626; doi: https://doi.org/10.1101/605626

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Spontaneous isomerization of long-lived proteins provides a molecular mechanism for the lysosomal failure observed in Alzheimer’s disease

Tyler R. Lambeth, Dylan L. Riggs, Lance E. Talbert, Jin Tang, Emily Coburn, Amrik S. Kang, Jessica Noll, Catherine Augello, Byron D. Ford, Ryan R. Julian

bioRxiv 605626; doi: https://doi.org/10.1101/605626

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