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Muller’s Ratchet and the Long-Term Fate of Chromosomal Inversions

Emma L. Berdan, View ORCID ProfileAlexandre Blanckaert, View ORCID ProfileRoger K. Butlin, View ORCID ProfileClaudia Bank
doi: https://doi.org/10.1101/606012
Emma L. Berdan
1Department of Marine Sciences, University of Gothenburg, Göteborg, Sweden
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  • For correspondence: emma.berdan@gmail.com blanckaert.a@gmail.com
Alexandre Blanckaert
2Instituto Gulbenkian de Ciência, Oeiras, Portugal
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  • For correspondence: emma.berdan@gmail.com blanckaert.a@gmail.com
Roger K. Butlin
1Department of Marine Sciences, University of Gothenburg, Göteborg, Sweden
3Department of Animal and Plant Sciences, University of Sheffield, Sheffield, UK
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Claudia Bank
2Instituto Gulbenkian de Ciência, Oeiras, Portugal
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Abstract

Chromosomal inversions contribute widely to adaptation and speciation, yet they present a unique evolutionary puzzle as both their allelic content and frequency evolve in a feedback loop. In this simulation study, we quantified the role of the allelic content in determining the long-term fate of the inversion. Recessive deleterious mutations accumulated rapidly on both arrangements with most of them being private to a given arrangement. The emerging overdominance led to maintenance of the inversion polymorphism and strong non-adaptive divergence between arrangements. The accumulation of mutations was mitigated by gene conversion but nevertheless led to the fitness decline of at least one homokaryotype. Surprisingly, this fitness degradation could be permanently halted by the branching of an arrangement into multiple highly divergent haplotypes. Our results highlight the dynamic features of inversions by showing how the non-adaptive evolution of allelic content can play a major role in the fate of the inversion.

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The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC 4.0 International license.
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Posted April 13, 2019.
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Muller’s Ratchet and the Long-Term Fate of Chromosomal Inversions
Emma L. Berdan, Alexandre Blanckaert, Roger K. Butlin, Claudia Bank
bioRxiv 606012; doi: https://doi.org/10.1101/606012
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Muller’s Ratchet and the Long-Term Fate of Chromosomal Inversions
Emma L. Berdan, Alexandre Blanckaert, Roger K. Butlin, Claudia Bank
bioRxiv 606012; doi: https://doi.org/10.1101/606012

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