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Aging induces Nlrp3 inflammasome dependent adipose B cell expansion to impair metabolic homeostasis

Christina D. Camell, Aileen Lee, Patrick Günther, Emily L. Goldberg, Olga Spadaro, Yun-Hee Youm, Andrzej Bartke, Gene B. Hubbard, Yuji Ikeno, Nancy H. Ruddle, Joachim Schultze, Vishwa Deep Dixit
doi: https://doi.org/10.1101/607192
Christina D. Camell
1Department of Comparative Medicine, Yale School of Medicine, New Haven, CT 06520, USA
2Department of Immunobiology, Yale School of Medicine, New Haven, CT 06520, USA
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Aileen Lee
1Department of Comparative Medicine, Yale School of Medicine, New Haven, CT 06520, USA
2Department of Immunobiology, Yale School of Medicine, New Haven, CT 06520, USA
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Patrick Günther
3Genomics and Immunoregulation, LIMES-Institute, University of Bonn, 53115, Bonn, Germany
4PRECISE Platform for Single Cell Genomics and Epigenomics at the University of Bonn and the German Center for Neurodegenerative Diseases, Bonn, Germany
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Emily L. Goldberg
1Department of Comparative Medicine, Yale School of Medicine, New Haven, CT 06520, USA
2Department of Immunobiology, Yale School of Medicine, New Haven, CT 06520, USA
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Olga Spadaro
1Department of Comparative Medicine, Yale School of Medicine, New Haven, CT 06520, USA
2Department of Immunobiology, Yale School of Medicine, New Haven, CT 06520, USA
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Yun-Hee Youm
1Department of Comparative Medicine, Yale School of Medicine, New Haven, CT 06520, USA
2Department of Immunobiology, Yale School of Medicine, New Haven, CT 06520, USA
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Andrzej Bartke
5Internal Medicine, Southern Illinois University, School of Medicine, Springfield, IL 62702 USA
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Gene B. Hubbard
6Department of Pathology, Barshop Institute, UT Health San Antonio, TX 78229
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Yuji Ikeno
6Department of Pathology, Barshop Institute, UT Health San Antonio, TX 78229
7Geriatric Research Education and Clinical Center, Audie L. Murphy VA Hospital, South Texas Veterans Health Care System, San Antonio, TX 78229
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Nancy H. Ruddle
8Department of Epidemiology of Microbial Diseases, Yale School of Public Health, New Haven, CT 06520, USA
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Joachim Schultze
3Genomics and Immunoregulation, LIMES-Institute, University of Bonn, 53115, Bonn, Germany
4PRECISE Platform for Single Cell Genomics and Epigenomics at the University of Bonn and the German Center for Neurodegenerative Diseases, Bonn, Germany
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Vishwa Deep Dixit
1Department of Comparative Medicine, Yale School of Medicine, New Haven, CT 06520, USA
2Department of Immunobiology, Yale School of Medicine, New Haven, CT 06520, USA
9Yale Center for Research on Aging, Yale School of Medicine, New Haven, CT 06520,USA
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  • For correspondence: Vishwa.Dixit@yale.edu
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Article Information

doi 
https://doi.org/10.1101/607192
History 
  • April 13, 2019.
Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC-ND 4.0 International license.

Author Information

  1. Christina D. Camell1,2,
  2. Aileen Lee1,2,
  3. Patrick Günther3,4,
  4. Emily L. Goldberg1,2,
  5. Olga Spadaro1,2,
  6. Yun-Hee Youm1,2,
  7. Andrzej Bartke5,
  8. Gene B. Hubbard6,
  9. Yuji Ikeno6,7,
  10. Nancy H. Ruddle8,
  11. Joachim Schultze3,4 and
  12. Vishwa Deep Dixit1,2,9,10
  1. 1Department of Comparative Medicine, Yale School of Medicine, New Haven, CT 06520, USA
  2. 2Department of Immunobiology, Yale School of Medicine, New Haven, CT 06520, USA
  3. 3Genomics and Immunoregulation, LIMES-Institute, University of Bonn, 53115, Bonn, Germany
  4. 4PRECISE Platform for Single Cell Genomics and Epigenomics at the University of Bonn and the German Center for Neurodegenerative Diseases, Bonn, Germany
  5. 5Internal Medicine, Southern Illinois University, School of Medicine, Springfield, IL 62702 USA
  6. 6Department of Pathology, Barshop Institute, UT Health San Antonio, TX 78229
  7. 7Geriatric Research Education and Clinical Center, Audie L. Murphy VA Hospital, South Texas Veterans Health Care System, San Antonio, TX 78229
  8. 8Department of Epidemiology of Microbial Diseases, Yale School of Public Health, New Haven, CT 06520, USA
  9. 9Yale Center for Research on Aging, Yale School of Medicine, New Haven, CT 06520,USA
  1. ↵10Address and Correspondence to: Vishwa Deep Dixit, Ph.D., Section of Comparative Medicine and Department of Immunobiology, Yale School of Medicine, 310 Cedar St, New Haven CT 06520, Email: Vishwa.Dixit{at}yale.edu, Phone: 203-785-2525, Fax: 203-785-7499
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Posted April 13, 2019.
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Aging induces Nlrp3 inflammasome dependent adipose B cell expansion to impair metabolic homeostasis
Christina D. Camell, Aileen Lee, Patrick Günther, Emily L. Goldberg, Olga Spadaro, Yun-Hee Youm, Andrzej Bartke, Gene B. Hubbard, Yuji Ikeno, Nancy H. Ruddle, Joachim Schultze, Vishwa Deep Dixit
bioRxiv 607192; doi: https://doi.org/10.1101/607192
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Aging induces Nlrp3 inflammasome dependent adipose B cell expansion to impair metabolic homeostasis
Christina D. Camell, Aileen Lee, Patrick Günther, Emily L. Goldberg, Olga Spadaro, Yun-Hee Youm, Andrzej Bartke, Gene B. Hubbard, Yuji Ikeno, Nancy H. Ruddle, Joachim Schultze, Vishwa Deep Dixit
bioRxiv 607192; doi: https://doi.org/10.1101/607192

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