Aging induces Nlrp3 inflammasome dependent adipose B cell expansion to impair metabolic homeostasis

Christina D. Camell; Aileen Lee; Patrick Günther; Emily L. Goldberg; Olga Spadaro; Yun-Hee Youm; Andrzej Bartke; Gene B. Hubbard; Yuji Ikeno; Nancy H. Ruddle; Joachim Schultze; Vishwa Deep Dixit

doi:10.1101/607192

New Results

Aging induces Nlrp3 inflammasome dependent adipose B cell expansion to impair metabolic homeostasis

Christina D. Camell, Aileen Lee, Patrick Günther, Emily L. Goldberg, Olga Spadaro, Yun-Hee Youm, Andrzej Bartke, Gene B. Hubbard, Yuji Ikeno, Nancy H. Ruddle, Joachim Schultze, Vishwa Deep Dixit

doi: https://doi.org/10.1101/607192

Christina D. Camell

1Department of Comparative Medicine, Yale School of Medicine, New Haven, CT 06520, USA

2Department of Immunobiology, Yale School of Medicine, New Haven, CT 06520, USA

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Aileen Lee

1Department of Comparative Medicine, Yale School of Medicine, New Haven, CT 06520, USA

2Department of Immunobiology, Yale School of Medicine, New Haven, CT 06520, USA

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Patrick Günther

3Genomics and Immunoregulation, LIMES-Institute, University of Bonn, 53115, Bonn, Germany

4PRECISE Platform for Single Cell Genomics and Epigenomics at the University of Bonn and the German Center for Neurodegenerative Diseases, Bonn, Germany

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Emily L. Goldberg

1Department of Comparative Medicine, Yale School of Medicine, New Haven, CT 06520, USA

2Department of Immunobiology, Yale School of Medicine, New Haven, CT 06520, USA

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Olga Spadaro

1Department of Comparative Medicine, Yale School of Medicine, New Haven, CT 06520, USA

2Department of Immunobiology, Yale School of Medicine, New Haven, CT 06520, USA

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Yun-Hee Youm

1Department of Comparative Medicine, Yale School of Medicine, New Haven, CT 06520, USA

2Department of Immunobiology, Yale School of Medicine, New Haven, CT 06520, USA

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Andrzej Bartke

5Internal Medicine, Southern Illinois University, School of Medicine, Springfield, IL 62702 USA

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Gene B. Hubbard

6Department of Pathology, Barshop Institute, UT Health San Antonio, TX 78229

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Yuji Ikeno

6Department of Pathology, Barshop Institute, UT Health San Antonio, TX 78229

7Geriatric Research Education and Clinical Center, Audie L. Murphy VA Hospital, South Texas Veterans Health Care System, San Antonio, TX 78229

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Nancy H. Ruddle

8Department of Epidemiology of Microbial Diseases, Yale School of Public Health, New Haven, CT 06520, USA

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Joachim Schultze

3Genomics and Immunoregulation, LIMES-Institute, University of Bonn, 53115, Bonn, Germany

4PRECISE Platform for Single Cell Genomics and Epigenomics at the University of Bonn and the German Center for Neurodegenerative Diseases, Bonn, Germany

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Vishwa Deep Dixit

1Department of Comparative Medicine, Yale School of Medicine, New Haven, CT 06520, USA

2Department of Immunobiology, Yale School of Medicine, New Haven, CT 06520, USA

9Yale Center for Research on Aging, Yale School of Medicine, New Haven, CT 06520,USA

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
For correspondence: Vishwa.Dixit@yale.edu

Abstract
Full Text
Info/History
Metrics
Supplementary material
Preview PDF

Article usage

Article usage: April 2019 to May 2023

	Abstract	Full	Pdf
Apr 2019	573	12	308
May 2019	104	13	114
Jun 2019	96	18	69
Jul 2019	60	7	41
Aug 2019	54	10	32
Oct 2019	83	7	39
Nov 2019	109	15	61
Dec 2019	77	8	38
Jan 2020	63	15	39
Feb 2020	68	24	24
Mar 2020	43	10	20
May 2020	79	5	14
Jun 2020	42	1	29
Jul 2020	14	0	15
Aug 2020	23	1	17
Sep 2020	37	1	15
Oct 2020	17	4	14
Nov 2020	27	5	19
Dec 2020	11	1	13
Jan 2021	2	1	12
Feb 2021	5	2	6
Mar 2021	21	3	6
Apr 2021	7	2	7
May 2021	3	0	13
Jun 2021	5	1	6
Jul 2021	4	1	6
Aug 2021	8	0	4
Sep 2021	6	1	18
Oct 2021	4	1	3
Nov 2021	17	4	12
Dec 2021	6	3	1
Jan 2022	12	2	3
Feb 2022	21	0	3
Mar 2022	15	0	3
Apr 2022	23	0	6
May 2022	28	0	9
Jun 2022	22	0	3
Jul 2022	25	0	3
Aug 2022	18	0	3
Sep 2022	31	0	3
Oct 2022	25	2	2
Nov 2022	10	0	5
Dec 2022	7	5	6
Jan 2023	1	3	5
Feb 2023	7	1	5
Mar 2023	8	1	10
Apr 2023	9	0	4
May 2023	3	0	3

View the discussion thread.

PreviousNext

Posted April 13, 2019.

Download PDF

Supplementary Material

Thank you for your interest in spreading the word about bioRxiv.

NOTE: Your email address is requested solely to identify you as the sender of this article.

Your Email *

Your Name *

Send To *

Enter multiple addresses on separate lines or separate them with commas.

You are going to email the following Aging induces Nlrp3 inflammasome dependent adipose B cell expansion to impair metabolic homeostasis

Message Subject (Your Name) has forwarded a page to you from bioRxiv

Message Body (Your Name) thought you would like to see this page from the bioRxiv website.

Your Personal Message

CAPTCHA

This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.

Aging induces Nlrp3 inflammasome dependent adipose B cell expansion to impair metabolic homeostasis

Christina D. Camell, Aileen Lee, Patrick Günther, Emily L. Goldberg, Olga Spadaro, Yun-Hee Youm, Andrzej Bartke, Gene B. Hubbard, Yuji Ikeno, Nancy H. Ruddle, Joachim Schultze, Vishwa Deep Dixit

bioRxiv 607192; doi: https://doi.org/10.1101/607192

Share This Article:

Citation Tools

Aging induces Nlrp3 inflammasome dependent adipose B cell expansion to impair metabolic homeostasis

Christina D. Camell, Aileen Lee, Patrick Günther, Emily L. Goldberg, Olga Spadaro, Yun-Hee Youm, Andrzej Bartke, Gene B. Hubbard, Yuji Ikeno, Nancy H. Ruddle, Joachim Schultze, Vishwa Deep Dixit

bioRxiv 607192; doi: https://doi.org/10.1101/607192

Citation Manager Formats

BibTeX
Bookends
EasyBib
EndNote (tagged)
EndNote 8 (xml)
Medlars
Mendeley
Papers
RefWorks Tagged
Ref Manager
RIS
Zotero

Tweet Widget
Facebook Like
Google Plus One

Subject Area

Immunology

Subject Areas

All Articles

Animal Behavior and Cognition (4381)
Biochemistry (9581)
Bioengineering (7087)
Bioinformatics (24847)
Biophysics (12598)
Cancer Biology (9952)
Cell Biology (14348)
Clinical Trials (138)
Developmental Biology (7945)
Ecology (12103)
Epidemiology (2067)
Evolutionary Biology (15985)
Genetics (10921)
Genomics (14736)
Immunology (9869)
Microbiology (23648)
Molecular Biology (9478)
Neuroscience (50841)
Paleontology (369)
Pathology (1539)
Pharmacology and Toxicology (2681)
Physiology (4013)
Plant Biology (8655)
Scientific Communication and Education (1508)
Synthetic Biology (2391)
Systems Biology (6427)
Zoology (1346)