Aging induces Nlrp3 inflammasome dependent adipose B cell expansion to impair metabolic homeostasis

Christina D. Camell; Aileen Lee; Patrick Günther; Emily L. Goldberg; Olga Spadaro; Yun-Hee Youm; Andrzej Bartke; Gene B. Hubbard; Yuji Ikeno; Nancy H. Ruddle; Joachim Schultze; Vishwa Deep Dixit

doi:10.1101/607192

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Aging induces Nlrp3 inflammasome dependent adipose B cell expansion to impair metabolic homeostasis

Christina D. Camell, Aileen Lee, Patrick Günther, Emily L. Goldberg, Olga Spadaro, Yun-Hee Youm, Andrzej Bartke, Gene B. Hubbard, Yuji Ikeno, Nancy H. Ruddle, Joachim Schultze, Vishwa Deep Dixit

doi: https://doi.org/10.1101/607192

Christina D. Camell

1Department of Comparative Medicine, Yale School of Medicine, New Haven, CT 06520, USA

2Department of Immunobiology, Yale School of Medicine, New Haven, CT 06520, USA

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Aileen Lee

1Department of Comparative Medicine, Yale School of Medicine, New Haven, CT 06520, USA

2Department of Immunobiology, Yale School of Medicine, New Haven, CT 06520, USA

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Patrick Günther

3Genomics and Immunoregulation, LIMES-Institute, University of Bonn, 53115, Bonn, Germany

4PRECISE Platform for Single Cell Genomics and Epigenomics at the University of Bonn and the German Center for Neurodegenerative Diseases, Bonn, Germany

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Emily L. Goldberg

1Department of Comparative Medicine, Yale School of Medicine, New Haven, CT 06520, USA

2Department of Immunobiology, Yale School of Medicine, New Haven, CT 06520, USA

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Olga Spadaro

1Department of Comparative Medicine, Yale School of Medicine, New Haven, CT 06520, USA

2Department of Immunobiology, Yale School of Medicine, New Haven, CT 06520, USA

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Yun-Hee Youm

1Department of Comparative Medicine, Yale School of Medicine, New Haven, CT 06520, USA

2Department of Immunobiology, Yale School of Medicine, New Haven, CT 06520, USA

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Andrzej Bartke

5Internal Medicine, Southern Illinois University, School of Medicine, Springfield, IL 62702 USA

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Gene B. Hubbard

6Department of Pathology, Barshop Institute, UT Health San Antonio, TX 78229

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Yuji Ikeno

6Department of Pathology, Barshop Institute, UT Health San Antonio, TX 78229

7Geriatric Research Education and Clinical Center, Audie L. Murphy VA Hospital, South Texas Veterans Health Care System, San Antonio, TX 78229

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Nancy H. Ruddle

8Department of Epidemiology of Microbial Diseases, Yale School of Public Health, New Haven, CT 06520, USA

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Joachim Schultze

3Genomics and Immunoregulation, LIMES-Institute, University of Bonn, 53115, Bonn, Germany

4PRECISE Platform for Single Cell Genomics and Epigenomics at the University of Bonn and the German Center for Neurodegenerative Diseases, Bonn, Germany

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Vishwa Deep Dixit

1Department of Comparative Medicine, Yale School of Medicine, New Haven, CT 06520, USA

2Department of Immunobiology, Yale School of Medicine, New Haven, CT 06520, USA

9Yale Center for Research on Aging, Yale School of Medicine, New Haven, CT 06520,USA

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For correspondence: Vishwa.Dixit@yale.edu

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Posted April 13, 2019.

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Aging induces Nlrp3 inflammasome dependent adipose B cell expansion to impair metabolic homeostasis

Christina D. Camell, Aileen Lee, Patrick Günther, Emily L. Goldberg, Olga Spadaro, Yun-Hee Youm, Andrzej Bartke, Gene B. Hubbard, Yuji Ikeno, Nancy H. Ruddle, Joachim Schultze, Vishwa Deep Dixit

bioRxiv 607192; doi: https://doi.org/10.1101/607192

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Aging induces Nlrp3 inflammasome dependent adipose B cell expansion to impair metabolic homeostasis

Christina D. Camell, Aileen Lee, Patrick Günther, Emily L. Goldberg, Olga Spadaro, Yun-Hee Youm, Andrzej Bartke, Gene B. Hubbard, Yuji Ikeno, Nancy H. Ruddle, Joachim Schultze, Vishwa Deep Dixit

bioRxiv 607192; doi: https://doi.org/10.1101/607192

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