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Lapses in perceptual decisions reflect exploration

View ORCID ProfileSashank Pisupati, Lital Chartarifsky-Lynn, Anup Khanal, View ORCID ProfileAnne K. Churchland
doi: https://doi.org/10.1101/613828
Sashank Pisupati
1Cold Spring Harbor Laboratory, Cold Spring Harbor, New York, USA
2Watson School of Biological Sciences, Cold Spring Harbor, New York, USA
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  • ORCID record for Sashank Pisupati
Lital Chartarifsky-Lynn
1Cold Spring Harbor Laboratory, Cold Spring Harbor, New York, USA
2Watson School of Biological Sciences, Cold Spring Harbor, New York, USA
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Anup Khanal
1Cold Spring Harbor Laboratory, Cold Spring Harbor, New York, USA
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Anne K. Churchland
1Cold Spring Harbor Laboratory, Cold Spring Harbor, New York, USA
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  • For correspondence: churchland@cshl.edu
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ABSTRACT

Perceptual decision-makers often display a constant rate of errors independent of evidence strength. These “lapses” are treated as a nuisance arising from noise tangential to the decision, e.g. inattention or motor errors. Here, we use a multisensory decision task in rats to demonstrate that these explanations cannot account for lapses’ stimulus dependence. We propose a novel explanation: lapses reflect a strategic trade-off between exploiting known rewarding actions and exploring uncertain ones. We tested the model’s predictions by selectively manipulating one action’s reward magnitude or probability. As uniquely predicted by this model, changes were restricted to lapses associated with that action. Finally, we show that lapses are a powerful tool for assigning decision-related computations to neural structures based on disruption experiments (here, posterior striatum and secondary motor cortex). These results suggest that lapses reflect an integral component of decision-making and are informative about action values in normal and disrupted brain states.

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  • Made minor revisions.

Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC-ND 4.0 International license.
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Posted June 01, 2019.
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Lapses in perceptual decisions reflect exploration
Sashank Pisupati, Lital Chartarifsky-Lynn, Anup Khanal, Anne K. Churchland
bioRxiv 613828; doi: https://doi.org/10.1101/613828
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Lapses in perceptual decisions reflect exploration
Sashank Pisupati, Lital Chartarifsky-Lynn, Anup Khanal, Anne K. Churchland
bioRxiv 613828; doi: https://doi.org/10.1101/613828

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