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Altered directed functional connectivity of the right amygdala in depression: high-density EEG study

Alena Damborská, Eliška Honzírková, Richard Barteček, Jana Hořínková, Sylvie Fedorová, Šimon Ondruš, Christoph M. Michel, Maria Rubega
doi: https://doi.org/10.1101/620252
Alena Damborská
1Department of Basic Neurosciences, University of Geneva, Campus Biotech, Geneva, Switzerland
2Department of Psychiatry, Faculty of Medicine, Masaryk University, Brno, Czech Republic
3Department of Psychiatry, University Hospital Brno, Brno, Czech Republic
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  • For correspondence: adambor@med.muni.cz
Eliška Honzírková
2Department of Psychiatry, Faculty of Medicine, Masaryk University, Brno, Czech Republic
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Richard Barteček
2Department of Psychiatry, Faculty of Medicine, Masaryk University, Brno, Czech Republic
3Department of Psychiatry, University Hospital Brno, Brno, Czech Republic
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Jana Hořínková
2Department of Psychiatry, Faculty of Medicine, Masaryk University, Brno, Czech Republic
3Department of Psychiatry, University Hospital Brno, Brno, Czech Republic
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Sylvie Fedorová
2Department of Psychiatry, Faculty of Medicine, Masaryk University, Brno, Czech Republic
3Department of Psychiatry, University Hospital Brno, Brno, Czech Republic
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Šimon Ondruš
2Department of Psychiatry, Faculty of Medicine, Masaryk University, Brno, Czech Republic
3Department of Psychiatry, University Hospital Brno, Brno, Czech Republic
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Christoph M. Michel
1Department of Basic Neurosciences, University of Geneva, Campus Biotech, Geneva, Switzerland
4Lemanic Biomedical Imaging Centre (CIBM), Lausanne and Geneva, Switzerland
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Maria Rubega
1Department of Basic Neurosciences, University of Geneva, Campus Biotech, Geneva, Switzerland
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Abstract

The cortico-striatal-pallidal-thalamic and limbic circuits are suggested to play a crucial role in the pathophysiology of depression. Stimulation of deep brain targets might improve symptoms in treatment-resistant depression. However, a better understanding of connectivity properties of deep brain structures potentially implicated in deep brain stimulation (DBS) treatment is needed. Using high-density EEG, we explored the directed functional connectivity at rest in 25 healthy subjects and 26 patients with moderate to severe depression within the bipolar affective disorder, depressive episode, and recurrent depressive disorder. We computed the Partial Directed Coherence on the source EEG signals focusing on the amygdala, anterior cingulate, putamen, pallidum, caudate, and thalamus. The global efficiency for the whole brain and the local efficiency, clustering coefficient, outflow, and strength for the selected structures were calculated. In the right amygdala, all the network metrics were significantly higher (p<0.001) in patients than in controls. The global efficiency was significantly higher (p<0.05) in patients than in controls, showed no correlation with status of depression, but decreased with increasing medication intake (R2 = 0.59 and p = 1.52e − 05). The amygdala seems to play an important role in neurobiology of depression. Practical treatment studies would be necessary to assess the amygdala as a potential future DBS target for treating depression.

Footnotes

  • This version of the manuscript has been revised to describe in detail the limitations of the study in a special section.

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The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY 4.0 International license.
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Posted February 23, 2020.
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Altered directed functional connectivity of the right amygdala in depression: high-density EEG study
Alena Damborská, Eliška Honzírková, Richard Barteček, Jana Hořínková, Sylvie Fedorová, Šimon Ondruš, Christoph M. Michel, Maria Rubega
bioRxiv 620252; doi: https://doi.org/10.1101/620252
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Altered directed functional connectivity of the right amygdala in depression: high-density EEG study
Alena Damborská, Eliška Honzírková, Richard Barteček, Jana Hořínková, Sylvie Fedorová, Šimon Ondruš, Christoph M. Michel, Maria Rubega
bioRxiv 620252; doi: https://doi.org/10.1101/620252

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