Human neutrophils produce antifungal extracellular vesicles against Aspergillus fumigatus

Iordana A. Shopova; Ivan Belyaev; Prasad Dasari; Susanne Jahreis; Maria C. Stroe; Zoltán Cseresnyés; Anna Medyukhina; Carl-Magnus Svensson; Thomas Krüger; Viktòria Szeifert; Sandor Nietzsche; Theresia Conrad; Olaf Kniemeyer; Marie von Lilienfeld-Toal; Peter F. Zipfel; Erzsébet Ligeti; Marc Thilo Figge; Axel A. Brakhage

doi:10.1101/620294

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Human neutrophils produce antifungal extracellular vesicles against Aspergillus fumigatus

Iordana A. Shopova, Ivan Belyaev, Prasad Dasari, Susanne Jahreis, Maria C. Stroe, Zoltán Cseresnyés, Anna Medyukhina, Carl-Magnus Svensson, Thomas Krüger, Viktòria Szeifert, Sandor Nietzsche, Theresia Conrad, Olaf Kniemeyer, Marie von Lilienfeld-Toal, Peter F. Zipfel, Erzsébet Ligeti, Marc Thilo Figge, Axel A. Brakhage

doi: https://doi.org/10.1101/620294

Iordana A. Shopova

1Institute for Microbiology, Friedrich Schiller University, Jena, Germany

2Department of Molecular and Applied Microbiology, Leibniz Institute for Natural Product Research and Infection Biology (HKI), Jena, Germany

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Ivan Belyaev

3Research Group Applied Systems Biology, Leibniz Institute for Natural Product Research and Infection Biology (HKI), Jena, Germany

9Friedrich Schiller University, Jena, Germany

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Prasad Dasari

4Department of Infection Biology, Leibniz Institute for Natural Product Research and Infection Biology (HKI), Jena, Germany

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Susanne Jahreis

5Clinic of Internal Medicine II, Haematology and Oncology, University Hospital Jena, Germany

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Maria C. Stroe

1Institute for Microbiology, Friedrich Schiller University, Jena, Germany

2Department of Molecular and Applied Microbiology, Leibniz Institute for Natural Product Research and Infection Biology (HKI), Jena, Germany

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Zoltán Cseresnyés

3Research Group Applied Systems Biology, Leibniz Institute for Natural Product Research and Infection Biology (HKI), Jena, Germany

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Anna Medyukhina

3Research Group Applied Systems Biology, Leibniz Institute for Natural Product Research and Infection Biology (HKI), Jena, Germany

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Carl-Magnus Svensson

3Research Group Applied Systems Biology, Leibniz Institute for Natural Product Research and Infection Biology (HKI), Jena, Germany

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Thomas Krüger

2Department of Molecular and Applied Microbiology, Leibniz Institute for Natural Product Research and Infection Biology (HKI), Jena, Germany

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Viktòria Szeifert

6Department of Physiology, Semmelweis University, Budapest, Hungary

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Sandor Nietzsche

7Centre for Electron Microscopy, Friedrich Schiller University, Jena, Germany

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Theresia Conrad

8Research Group Systems Biology and Bioinformatics, Leibniz Institute for Natural Product Research and Infection Biology (HKI), Jena, Germany

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Olaf Kniemeyer

2Department of Molecular and Applied Microbiology, Leibniz Institute for Natural Product Research and Infection Biology (HKI), Jena, Germany

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Marie von Lilienfeld-Toal

5Clinic of Internal Medicine II, Haematology and Oncology, University Hospital Jena, Germany

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Peter F. Zipfel

1Institute for Microbiology, Friedrich Schiller University, Jena, Germany

4Department of Infection Biology, Leibniz Institute for Natural Product Research and Infection Biology (HKI), Jena, Germany

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Erzsébet Ligeti

6Department of Physiology, Semmelweis University, Budapest, Hungary

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Marc Thilo Figge

3Research Group Applied Systems Biology, Leibniz Institute for Natural Product Research and Infection Biology (HKI), Jena, Germany

9Friedrich Schiller University, Jena, Germany

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Axel A. Brakhage

1Institute for Microbiology, Friedrich Schiller University, Jena, Germany

2Department of Molecular and Applied Microbiology, Leibniz Institute for Natural Product Research and Infection Biology (HKI), Jena, Germany

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For correspondence: axel.brakhage@uni-jena.de

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Human neutrophils produce antifungal extracellular vesicles against Aspergillus fumigatus

bioRxiv 620294; doi: https://doi.org/10.1101/620294

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Human neutrophils produce antifungal extracellular vesicles against Aspergillus fumigatus

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