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Proinflammatory and autoimmunogenic gut microbiome in systemic lupus erythematosus

View ORCID ProfileBei-di Chen, Xin-miao Jia, Jia-yue Xu, Li-dan Zhao, Jun-yi Ji, Bing-xuan Wu, Yun-yun Fei, Hua-xia Yang, Hua Chen, Xiao-xia Zuo, Hui Li, Wen-you Pan, View ORCID ProfileXiao-han Wang, Shuang Ye, Dong-geng Guo, Li Wang, Jing Li, Lin-yi Peng, Wen-jie Zheng, View ORCID ProfileWen Zhang, Feng-chun Zhang, Jian-min Zhang, Wei He, Xue-tao Cao, De-pei Liu, Jun Wang, Xuan Zhang
doi: https://doi.org/10.1101/621995
Bei-di Chen
1Department of Rheumatology and Clinical Immunology, Chinese Academy of Medical Sciences (CAMS) & Peking Union Medical College Hospital, Beijing, China, 100730
2Clinical Immunology Centre, Medical Epigenetics Research Centre, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China, 100730
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  • ORCID record for Bei-di Chen
Xin-miao Jia
1Department of Rheumatology and Clinical Immunology, Chinese Academy of Medical Sciences (CAMS) & Peking Union Medical College Hospital, Beijing, China, 100730
2Clinical Immunology Centre, Medical Epigenetics Research Centre, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China, 100730
3Central Research Laboratory, Chinese Academy of Medical Sciences (CAMS) & Peking Union Medical College Hospital, Beijing, China, 100730
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Jia-yue Xu
4CAS Key Laboratory for Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, China, 100101
5University of Chinese Academy of Sciences, Beijing, China, 100049
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Li-dan Zhao
1Department of Rheumatology and Clinical Immunology, Chinese Academy of Medical Sciences (CAMS) & Peking Union Medical College Hospital, Beijing, China, 100730
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Jun-yi Ji
6School of Medicine, Tsinghua University, No.1 Tsinghua Yuan, Beijing, China, 100084
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Bing-xuan Wu
1Department of Rheumatology and Clinical Immunology, Chinese Academy of Medical Sciences (CAMS) & Peking Union Medical College Hospital, Beijing, China, 100730
2Clinical Immunology Centre, Medical Epigenetics Research Centre, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China, 100730
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Yun-yun Fei
1Department of Rheumatology and Clinical Immunology, Chinese Academy of Medical Sciences (CAMS) & Peking Union Medical College Hospital, Beijing, China, 100730
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Hua-xia Yang
1Department of Rheumatology and Clinical Immunology, Chinese Academy of Medical Sciences (CAMS) & Peking Union Medical College Hospital, Beijing, China, 100730
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Hua Chen
1Department of Rheumatology and Clinical Immunology, Chinese Academy of Medical Sciences (CAMS) & Peking Union Medical College Hospital, Beijing, China, 100730
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Xiao-xia Zuo
7Department of Rheumatology, Xiangya Hospital, Central South University, Changsha, Hunan, China, 410008
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Hui Li
8Department of Immunology and Rheumatology, Huaian First People’s Hospital, Nanjing Medical University, Huaian, Jiangsu, China, 223300
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Wen-you Pan
8Department of Immunology and Rheumatology, Huaian First People’s Hospital, Nanjing Medical University, Huaian, Jiangsu, China, 223300
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Xiao-han Wang
9Department of Rheumatology, Anyang District Hospital, Anyang, Henan, China, 455002
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Shuang Ye
10Department of Rheumatology, South Campus, Renji Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China, 200025
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Dong-geng Guo
11Department of Rheumatology, Ningxia Hui Autonomous Region Peoples Hospital, Affiliated People’s Hospital of Ningxia Medical University, First Affiliated Hospital of Northwest Minzu University, Ningxia Hui Autonomous Region, China, 750000
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Li Wang
1Department of Rheumatology and Clinical Immunology, Chinese Academy of Medical Sciences (CAMS) & Peking Union Medical College Hospital, Beijing, China, 100730
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Jing Li
1Department of Rheumatology and Clinical Immunology, Chinese Academy of Medical Sciences (CAMS) & Peking Union Medical College Hospital, Beijing, China, 100730
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Lin-yi Peng
1Department of Rheumatology and Clinical Immunology, Chinese Academy of Medical Sciences (CAMS) & Peking Union Medical College Hospital, Beijing, China, 100730
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Wen-jie Zheng
1Department of Rheumatology and Clinical Immunology, Chinese Academy of Medical Sciences (CAMS) & Peking Union Medical College Hospital, Beijing, China, 100730
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Wen Zhang
1Department of Rheumatology and Clinical Immunology, Chinese Academy of Medical Sciences (CAMS) & Peking Union Medical College Hospital, Beijing, China, 100730
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Feng-chun Zhang
1Department of Rheumatology and Clinical Immunology, Chinese Academy of Medical Sciences (CAMS) & Peking Union Medical College Hospital, Beijing, China, 100730
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Jian-min Zhang
12Department of Immunology & National Key Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences (CAMS) & Peking Union Medical College, Beijing, China, 100005
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Wei He
12Department of Immunology & National Key Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences (CAMS) & Peking Union Medical College, Beijing, China, 100005
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Xue-tao Cao
12Department of Immunology & National Key Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences (CAMS) & Peking Union Medical College, Beijing, China, 100005
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De-pei Liu
2Clinical Immunology Centre, Medical Epigenetics Research Centre, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China, 100730
12Department of Immunology & National Key Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences (CAMS) & Peking Union Medical College, Beijing, China, 100005
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Jun Wang
4CAS Key Laboratory for Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, China, 100101
5University of Chinese Academy of Sciences, Beijing, China, 100049
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  • For correspondence: zxpumch2003@sina.com junwang@im.ac.cn
Xuan Zhang
1Department of Rheumatology and Clinical Immunology, Chinese Academy of Medical Sciences (CAMS) & Peking Union Medical College Hospital, Beijing, China, 100730
2Clinical Immunology Centre, Medical Epigenetics Research Centre, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China, 100730
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  • For correspondence: zxpumch2003@sina.com junwang@im.ac.cn
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Article Information

doi 
https://doi.org/10.1101/621995
History 
  • April 29, 2019.
Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. All rights reserved. No reuse allowed without permission.

Author Information

  1. Bei-di Chen1,2,†,
  2. Xin-miao Jia1,2,3,†,
  3. Jia-yue Xu4,5,†,
  4. Li-dan Zhao1,
  5. Jun-yi Ji6,
  6. Bing-xuan Wu1,2,
  7. Yun-yun Fei1,
  8. Hua-xia Yang1,
  9. Hua Chen1,
  10. Xiao-xia Zuo7,
  11. Hui Li8,
  12. Wen-you Pan8,
  13. Xiao-han Wang9,
  14. Shuang Ye10,
  15. Dong-geng Guo11,
  16. Li Wang1,
  17. Jing Li1,
  18. Lin-yi Peng1,
  19. Wen-jie Zheng1,
  20. Wen Zhang1,
  21. Feng-chun Zhang1,
  22. Jian-min Zhang12,
  23. Wei He12,
  24. Xue-tao Cao12,
  25. De-pei Liu2,12,
  26. Jun Wang4,5,* and
  27. Xuan Zhang1,2,*
  1. 1Department of Rheumatology and Clinical Immunology, Chinese Academy of Medical Sciences (CAMS) & Peking Union Medical College Hospital, Beijing, China, 100730
  2. 2Clinical Immunology Centre, Medical Epigenetics Research Centre, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China, 100730
  3. 3Central Research Laboratory, Chinese Academy of Medical Sciences (CAMS) & Peking Union Medical College Hospital, Beijing, China, 100730
  4. 4CAS Key Laboratory for Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, China, 100101
  5. 5University of Chinese Academy of Sciences, Beijing, China, 100049
  6. 6School of Medicine, Tsinghua University, No.1 Tsinghua Yuan, Beijing, China, 100084
  7. 7Department of Rheumatology, Xiangya Hospital, Central South University, Changsha, Hunan, China, 410008
  8. 8Department of Immunology and Rheumatology, Huaian First People’s Hospital, Nanjing Medical University, Huaian, Jiangsu, China, 223300
  9. 9Department of Rheumatology, Anyang District Hospital, Anyang, Henan, China, 455002
  10. 10Department of Rheumatology, South Campus, Renji Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China, 200025
  11. 11Department of Rheumatology, Ningxia Hui Autonomous Region Peoples Hospital, Affiliated People’s Hospital of Ningxia Medical University, First Affiliated Hospital of Northwest Minzu University, Ningxia Hui Autonomous Region, China, 750000
  12. 12Department of Immunology & National Key Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences (CAMS) & Peking Union Medical College, Beijing, China, 100005
  1. ↵*Corresponding authors: Xuan Zhang, No.1 Shuai-Fu-Yuan, Dong-Cheng District, Beijing, China, 100730, TEL: +86-010-69159952, Email: zxpumch2003{at}sina.com Jun Wang, No.1 Bei-Chen West Road, Chao-Yang District, Beijing, China, 100101, TEL: +86-010-64807502, Email: junwang{at}im.ac.cn
  1. ↵† Bei-di Chen, Xin-miao Jia and Jia-yue Xu contributed equally to this work.

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Proinflammatory and autoimmunogenic gut microbiome in systemic lupus erythematosus
Bei-di Chen, Xin-miao Jia, Jia-yue Xu, Li-dan Zhao, Jun-yi Ji, Bing-xuan Wu, Yun-yun Fei, Hua-xia Yang, Hua Chen, Xiao-xia Zuo, Hui Li, Wen-you Pan, Xiao-han Wang, Shuang Ye, Dong-geng Guo, Li Wang, Jing Li, Lin-yi Peng, Wen-jie Zheng, Wen Zhang, Feng-chun Zhang, Jian-min Zhang, Wei He, Xue-tao Cao, De-pei Liu, Jun Wang, Xuan Zhang
bioRxiv 621995; doi: https://doi.org/10.1101/621995
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Proinflammatory and autoimmunogenic gut microbiome in systemic lupus erythematosus
Bei-di Chen, Xin-miao Jia, Jia-yue Xu, Li-dan Zhao, Jun-yi Ji, Bing-xuan Wu, Yun-yun Fei, Hua-xia Yang, Hua Chen, Xiao-xia Zuo, Hui Li, Wen-you Pan, Xiao-han Wang, Shuang Ye, Dong-geng Guo, Li Wang, Jing Li, Lin-yi Peng, Wen-jie Zheng, Wen Zhang, Feng-chun Zhang, Jian-min Zhang, Wei He, Xue-tao Cao, De-pei Liu, Jun Wang, Xuan Zhang
bioRxiv 621995; doi: https://doi.org/10.1101/621995

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