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Rapid evolution and biogeographic spread in a colorectal cancer

View ORCID ProfileJoao M Alves, Sonia Prado-Lopez, View ORCID ProfileJose Manuel Cameselle-Teijeiro, View ORCID ProfileDavid Posada
doi: https://doi.org/10.1101/623850
Joao M Alves
Department of Biochemistry, Genetics and Immunology, University of Vigo, SpainBiomedical Research Center (CINBIO), University of Vigo, SpainGalicia Sur Health Research Institute, Vigo, Spain
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Sonia Prado-Lopez
Department of Biochemistry, Genetics and Immunology, University of Vigo, SpainBiomedical Research Center (CINBIO), University of Vigo, SpainGalicia Sur Health Research Institute, Vigo, Spain
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Jose Manuel Cameselle-Teijeiro
Department of Pathology, Clinical University Hospital, Galician Healthcare Service (SERGAS), Santiago de Compostela, SpainMedical Faculty, University of Santiago de Compostela, Santiago de Compostela, Spain
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David Posada
Department of Biochemistry, Genetics and Immunology, University of Vigo, SpainBiomedical Research Center (CINBIO), University of Vigo, SpainGalicia Sur Health Research Institute, Vigo, Spain
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  • For correspondence: dposada@uvigo.es
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ABSTRACT

How and when tumoral clones start spreading to surrounding and distant tissues is currently unclear. Here, we leveraged a model-based evolutionary framework to investigate the demographic and biogeographic history of a colorectal cancer. Our analyses strongly support an early monoclonal metastatic colonization, followed by a rapid population expansion at both primary and secondary sites. Moreover, we infer a hematogenous metastatic spread seemingly under positive selection, plus the return of some tumoral cells from the liver back to the colon lymph nodes. This study illustrates how sophisticated techniques typical of organismal evolution can provide a detailed picture of the complex tumoral dynamics over time and space.

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The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC-ND 4.0 International license.
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Posted May 02, 2019.
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Rapid evolution and biogeographic spread in a colorectal cancer
Joao M Alves, Sonia Prado-Lopez, Jose Manuel Cameselle-Teijeiro, David Posada
bioRxiv 623850; doi: https://doi.org/10.1101/623850
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Rapid evolution and biogeographic spread in a colorectal cancer
Joao M Alves, Sonia Prado-Lopez, Jose Manuel Cameselle-Teijeiro, David Posada
bioRxiv 623850; doi: https://doi.org/10.1101/623850

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