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Multiple non-auditory cortical regions innervate the auditory midbrain

View ORCID ProfileBas MJ Olthof, View ORCID ProfileAdrian Rees, View ORCID ProfileSarah E Gartside
doi: https://doi.org/10.1101/627232
Bas MJ Olthof
Institute of Neuroscience, Newcastle University, Newcastle upon Tyne, NE2 4HH, UK
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  • For correspondence: bas.olthof@ncl.ac.uk
Adrian Rees
Institute of Neuroscience, Newcastle University, Newcastle upon Tyne, NE2 4HH, UK
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Sarah E Gartside
Institute of Neuroscience, Newcastle University, Newcastle upon Tyne, NE2 4HH, UK
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  • ORCID record for Sarah E Gartside
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ABSTRACT

In sensory perception, feedback connections from higher to lower levels in the processing hierarchy are considered to be of major importance. In the auditory system, connections from the auditory cortex to the inferior colliculus -the auditory midbrain- are well established, but the existence of inputs to the inferior colliculus from other, non-auditory,-cortical areas has not been systematically investigated. Using retrograde tracing we show that visual, somatosensory, motor, and prefrontal cortices all project extensively to the inferior colliculus. These connections are bilateral, with an ipsilateral dominance, but those from motor and prefrontal cortex show a less pronounced lateralization. Anterograde tracing reveals that cortical fibres terminate in all three subdivisions of the inferior colliculus, and target both GABAergic inhibitory, and putative glutamatergic excitatory neurons. These findings indicate that sound processing in the auditory midbrain is influenced by multiple sensory, behavioural, and executive cortical systems.

Footnotes

  • ↵* Bas Olthof, Institute of Neuroscience, Faculty of Medical Sciences, Newcastle upon Tyne, NE2 4HH UK, bas.olthof{at}ncl.ac.uk

  • LIST OF ABBREVIATIONS

    AC
    auditory cortex
    AI
    agranular insular cortex
    Au1
    primary auditory cortex
    AuD
    secondary auditory cortex dorsal zone
    AuV
    secondary auditory cortex, ventral zone
    Cg1
    cingulate cortex area 1
    Cg2
    cingulate cortex area 2
    Den
    dorsal endopiriform nucleus
    DI
    dysgranular insular cortex
    DP
    dorsal peduncular cortex
    DZ
    primary somatosensory cortex dorsal zone
    Ect
    ectorhinal cortex
    GI
    granular insular cortex
    IL
    infralimbic cortex
    LO
    lateral orbital cortex
    M1
    primary motor cortex
    M2
    secondary motor cortex
    MC
    motor cortex
    MO
    medial orbital cortex
    PFC
    prefrontal cortex
    Prh
    perirhinal cortex
    PrL
    prelimbic cortex
    RSG
    retrosplenial granular cortex
    S1
    primary somatosensory cortex
    S1Tr
    primary somatosensory cortex trunk region
    S2
    secondary somatosensory cortex
    SC
    somatosensory cortex
    TeA
    temporal association cortex
    V1B
    primary visual cortex, binocular area
    V1M
    primary visual cortex, monocular area
    V2L
    secondary visual cortex, lateral area
    V2M
    secondary visual cortex, mediolateral area
    VC
    visual cortex
    VO
    ventral orbital cortex.
  • Copyright 
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    Posted May 03, 2019.
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    Multiple non-auditory cortical regions innervate the auditory midbrain
    Bas MJ Olthof, Adrian Rees, Sarah E Gartside
    bioRxiv 627232; doi: https://doi.org/10.1101/627232
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    Multiple non-auditory cortical regions innervate the auditory midbrain
    Bas MJ Olthof, Adrian Rees, Sarah E Gartside
    bioRxiv 627232; doi: https://doi.org/10.1101/627232

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