New Results
Stem cell-derived cranial and spinal motor neurons reveal proteostatic differences between ALS resistant and sensitive motor neurons
Disi An, Ryosuke Fujiki, Dylan E. Iannitelli, John W. Smerdon, Shuvadeep Maity, Matthew F. Rose, Alon Gelber, Elizabeth K. Wanaselja, Ilona Yagudayeva, Joun Y. Lee, Christine Vogel, Hynek Wichterle, Elizabeth C. Engle, View ORCID ProfileEsteban O. Mazzoni
doi: https://doi.org/10.1101/629295
Disi An
1Department of Biology, New York University (NYU), New York, NY 10003, USA
Ryosuke Fujiki
2Department of Neurology, Boston Children’s Hospital, Boston, Massachusetts 02115, USA
3FM Kirby Neurobiology Center, Boston Children’s Hospital, Boston, Massachusetts 02115, USA
4Department of Neurology, Harvard Medical School, Boston, Massachusetts 02115, USA
5Medical Genetics Training Program, Harvard Medical School, Boston, Massachusetts 02115, USA
16Department of Neurology, Kokura Memorial Hospital, Kitakyushu, Fukuoka 802-0001, Japan
Dylan E. Iannitelli
1Department of Biology, New York University (NYU), New York, NY 10003, USA
John W. Smerdon
6Department of Physiology and Cellular Biophysics, Columbia University Medical Center, New York, NY 10032, USA
Shuvadeep Maity
1Department of Biology, New York University (NYU), New York, NY 10003, USA
7Center for Genomics and Systems Biology, NYU, New York, NY 10003, USA
Matthew F. Rose
2Department of Neurology, Boston Children’s Hospital, Boston, Massachusetts 02115, USA
3FM Kirby Neurobiology Center, Boston Children’s Hospital, Boston, Massachusetts 02115, USA
5Medical Genetics Training Program, Harvard Medical School, Boston, Massachusetts 02115, USA
8Department of Pathology, Brigham and Women’s Hospital, Boston, Massachusetts 02115, USA
9Department of Pathology, Boston Children’s Hospital, Boston, Massachusetts 02115, USA
10Department of Pathology, Harvard Medical School, Boston, Massachusetts 02115, USA
11Broad Institute of M.I.T. and Harvard, Cambridge, Massachusetts 02142, USA
Alon Gelber
2Department of Neurology, Boston Children’s Hospital, Boston, Massachusetts 02115, USA
3FM Kirby Neurobiology Center, Boston Children’s Hospital, Boston, Massachusetts 02115, USA
11Broad Institute of M.I.T. and Harvard, Cambridge, Massachusetts 02142, USA
Elizabeth K. Wanaselja
1Department of Biology, New York University (NYU), New York, NY 10003, USA
Ilona Yagudayeva
1Department of Biology, New York University (NYU), New York, NY 10003, USA
Joun Y. Lee
2Department of Neurology, Boston Children’s Hospital, Boston, Massachusetts 02115, USA
3FM Kirby Neurobiology Center, Boston Children’s Hospital, Boston, Massachusetts 02115, USA
17Department of Genetics, Albert Einstein College of Medicine, Bronx, New York 10461, USA
Christine Vogel
1Department of Biology, New York University (NYU), New York, NY 10003, USA
7Center for Genomics and Systems Biology, NYU, New York, NY 10003, USA
Hynek Wichterle
6Department of Physiology and Cellular Biophysics, Columbia University Medical Center, New York, NY 10032, USA
Elizabeth C. Engle
2Department of Neurology, Boston Children’s Hospital, Boston, Massachusetts 02115, USA
3FM Kirby Neurobiology Center, Boston Children’s Hospital, Boston, Massachusetts 02115, USA
4Department of Neurology, Harvard Medical School, Boston, Massachusetts 02115, USA
5Medical Genetics Training Program, Harvard Medical School, Boston, Massachusetts 02115, USA
11Broad Institute of M.I.T. and Harvard, Cambridge, Massachusetts 02142, USA
12Howard Hughes Medical Institute, Chevy Chase, Maryland 20815, USA
13Department of Ophthalmology, Boston Children’s Hospital, Boston, Massachusetts 02115, USA
14Department of Ophthalmology, Harvard Medical School, Boston, Massachusetts 02115, USA
Esteban O. Mazzoni
1Department of Biology, New York University (NYU), New York, NY 10003, USA
15NYU Neuroscience Institute, NYU Langone Medical Center, New York, NY 10016, USA
Article usage
Posted May 07, 2019.
Stem cell-derived cranial and spinal motor neurons reveal proteostatic differences between ALS resistant and sensitive motor neurons
Disi An, Ryosuke Fujiki, Dylan E. Iannitelli, John W. Smerdon, Shuvadeep Maity, Matthew F. Rose, Alon Gelber, Elizabeth K. Wanaselja, Ilona Yagudayeva, Joun Y. Lee, Christine Vogel, Hynek Wichterle, Elizabeth C. Engle, Esteban O. Mazzoni
bioRxiv 629295; doi: https://doi.org/10.1101/629295
Stem cell-derived cranial and spinal motor neurons reveal proteostatic differences between ALS resistant and sensitive motor neurons
Disi An, Ryosuke Fujiki, Dylan E. Iannitelli, John W. Smerdon, Shuvadeep Maity, Matthew F. Rose, Alon Gelber, Elizabeth K. Wanaselja, Ilona Yagudayeva, Joun Y. Lee, Christine Vogel, Hynek Wichterle, Elizabeth C. Engle, Esteban O. Mazzoni
bioRxiv 629295; doi: https://doi.org/10.1101/629295
Subject Area
Subject Areas
- Biochemistry (11752)
- Bioengineering (8752)
- Bioinformatics (29200)
- Biophysics (14974)
- Cancer Biology (12096)
- Cell Biology (17411)
- Clinical Trials (138)
- Developmental Biology (9421)
- Ecology (14182)
- Epidemiology (2067)
- Evolutionary Biology (18308)
- Genetics (12245)
- Genomics (16803)
- Immunology (11869)
- Microbiology (28097)
- Molecular Biology (11594)
- Neuroscience (60969)
- Paleontology (451)
- Pathology (1871)
- Pharmacology and Toxicology (3238)
- Physiology (4959)
- Plant Biology (10427)
- Synthetic Biology (2886)
- Systems Biology (7340)
- Zoology (1651)